Results 21 to 30 of about 2,850 (181)

An Unpleasant Souvenir: Whipworm as an Incidental Finding During a Screening Colonoscopy [PDF]

Journal of Investigative Medicine High Impact Case Reports
Trichuriasis is a neglected tropical disease caused by Trichuris trichiura that spreads through the ingestion of embryonated eggs in contaminated soil, water, or food.
Lefika Bathobakae MD, MPH, Tyler Wilkinson MSc, Saif Yasin BS, Rammy Bashir MSc, Nargis Mateen MD, Ruhin Yuridullah MD, Yana Cavanagh MD, Walid Baddoura MD, Jin Suh MD, FACP, FIDSA   +8 more
doaj   +2 more sources

Whipworm-Associated Intestinal Microbiome Members Consistent Across Both Human and Mouse Hosts

Frontiers in Cellular and Infection Microbiology, 2021
The human whipworm Trichuris trichiura infects 289 million people worldwide, resulting in substantial morbidity. Whipworm infections are difficult to treat due to low cure rates and high reinfection rates.
Bruce A. Rosa, Caroline Snowden, John Martin, Kerstin Fischer, Jonah Kupritz, Ethiopia Beshah, Taniawati Supali, Lincoln Gankpala, Peter U. Fischer, Joseph F. Urban, Makedonka Mitreva, Makedonka Mitreva, Makedonka Mitreva   +12 more
doaj   +1 more source

Soil-Transmitted Helminths and Anaemia: A Neglected Association Outside the Tropics

Microorganisms, 2022
Anaemia is an important cause of morbidity and mortality globally. Among infectious agents responsible for anaemia, helminthic infections are often neglected, particularly in non-endemic countries.
Sara Caldrer, Tamara Ursini, Beatrice Santucci, Leonardo Motta, Andrea Angheben   +4 more
doaj   +1 more source

Prevalence and Seasonal Variation of Trichuris Worms Infection in Mastomys natalensis in Morogoro and Iringa Regions, Tanzania

Parasitologia, 2023
Trichuriosis is a disease in mammals caused by the whipworms of the genus Trichuris. These worms are known for the high disease burden they cause in humans and domestic animals, especially in sub-Saharan Africa.
Claus Thomas, Venance Msoffe, Natalie Van Houtte, Ginethon Mhamphi, Joachim Mariën, Christopher Sabuni, Isaac Makundi, Jahashi Nzalawahe, Robert Machang’u, Herwig Leirs   +9 more
doaj   +1 more source

A drug repurposing screen for whipworms informed by comparative genomics.

PLoS Neglected Tropical Diseases, 2023
Hundreds of millions of people worldwide are infected with the whipworm Trichuris trichiura. Novel treatments are urgently needed as current drugs, such as albendazole, have relatively low efficacy.
Avril Coghlan, Frederick A Partridge, María Adelaida Duque-Correa, Gabriel Rinaldi, Simon Clare, Lisa Seymour, Cordelia Brandt, Tapoka T Mkandawire, Catherine McCarthy, Nancy Holroyd, Marina Nick, Anwen E Brown, Sirapat Tonitiwong, David B Sattelle, Matthew Berriman   +14 more
doaj   +1 more source

Anthelmintic Activity of Yeast Particle-Encapsulated Terpenes

Molecules, 2020
Soil-transmitted nematodes (STN) infect 1–2 billion of the poorest people worldwide. Only benzimidazoles are currently used in mass drug administration, with many instances of reduced activity. Terpenes are a class of compounds with anthelmintic activity.
Zeynep Mirza, Ernesto R. Soto, Yan Hu, Thanh-Thanh Nguyen, David Koch, Raffi V. Aroian, Gary R. Ostroff   +6 more
doaj   +1 more source

Using Routinely Collected Health Records to Identify the Fine-Resolution Spatial Patterns of Soil-Transmitted Helminth Infections in Rwanda

Tropical Medicine and Infectious Disease, 2022
Background. Soil-transmitted helminths (STH) are parasitic diseases with significant public health impact. Analysis is generally based on cross-sectional prevalence surveys; outcomes are mostly aggregated to larger spatial units. However, recent research
Elias Nyandwi, Tom Veldkamp, Sherif Amer, Eugene Ruberanziza, Nadine Rujeni, Ireneé Umulisa   +5 more
doaj   +1 more source

Experimental infection of pigs with three dose levels of Trichuris suis

Parasite, 2000
The objective of the study was to follow the course of Trichuris suisinfection in pigs given infective eggs at low (400 eggs), medium (4,000 eggs) and high inoculation dose (40,000 eggs), respectively. Interestingly, despite a 100-fold difference in dose
Pedersen S., Saeed I.
doaj   +1 more source

Host age influence on the intensity of experimental Trichuris suis infection in pigs

Parasite, 2002
The impact of age-related resistance on the regulation of population dynamics of adult Trichuris suis was investigated in an experimental pig model. Helminth-naive pigs varying in age from five weeks to four years were infected with T.
Pedersen S., Saeed I.
doaj   +1 more source

Population genomics of ancient and modern Trichuris trichiura

Nature Communications, 2022
The whipworm Trichuris trichiura is a soil-transmitted helminth that causes the neglected tropical disease trichuriasis in humans. Here, the authors produce whole genome sequences of modern and ancient samples from humans and non-human primates to ...
Stephen R. Doyle, Martin Jensen Søe, Peter Nejsum, Martha Betson, Philip J. Cooper, Lifei Peng, Xing-Quan Zhu, Ana Sanchez, Gabriela Matamoros, Gustavo Adolfo Fontecha Sandoval, Cristina Cutillas, Louis-Albert Tchuem Tchuenté, Zeleke Mekonnen, Shaali M. Ame, Harriet Namwanje, Bruno Levecke, Matthew Berriman, Brian Lund Fredensborg, Christian Moliin Outzen Kapel   +18 more
doaj   +1 more source