Results 1 to 10 of about 1,747 (121)

Selective Packaging of miR‐22 and miR‐29 Orthologues into Extracellular Vesicles of the Porcine Whipworm Trichuris Suis [PDF]

Journal of Extracellular Vesicles
Helminths modulate host immunity, and in this respect, the porcine whipworm Trichuris suis has been explored clinically as an immunotherapy for inflammatory diseases. T.
Bradley Whitehead, Maibritt Mardahl, Eline P. Hansen, Bastian Fromm, Anne Borup, Anders Toftegaard Boysen, Jasmine C. L. Atay, Rikke Nørregaard, Allan Stensballe, Sidsel D. Andersen, Robin B. Gasser, Marco Brucale, Francesco Valle, Andrea Ridolfi, Eske Nøhr Glud, Merete Fredholm, Andrew R. Williams, Stig M. Thamsborg, Johan Palmfedt, Peter Nejsum   +19 more
doaj   +3 more sources

Safety of viable embryonated eggs of the whipworm Trichuris suis as a novel food pursuant to Regulation (EU) 2015/2283 [PDF]

EFSA Journal, 2019
Following a request from the European Commission, the EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA) was asked to deliver an opinion on viable embryonated eggs of the whipworm Trichuris suis as a novel food (NF) pursuant to Regulation (EU)
Sophia Tsabouri, Morten Poulsen, Marco Vinceti   +2 more
exaly   +3 more sources

Trichuris suis and Oesophagostomum dentatum Show Different Sensitivity and Accumulation of Fenbendazole, Albendazole and Levamisole In Vitro [PDF]

PLoS Neglected Tropical Diseases, 2014
BackgroundThe single-dose benzimidazoles used against Trichuris trichiura infections in humans are not satisfactory. Likewise, the benzimidazole, fenbendazole, has varied efficacy against Trichuris suis whereas Oesophagostomum dentatum is highly ...
Christian Friis, Annette Olsen, Tina V Hansen   +2 more
exaly   +4 more sources

Pathway of oxfendazole from the host into the worm: Trichuris suis in pigs [PDF]

International Journal for Parasitology: Drugs and Drug Resistance, 2017
It is well known that the efficacy of a single oral dose of benzimidazoles against Trichuris spp. infections in humans and animals is poor, but is currently still used in control programmes against human trichuriasis.
Tina V.A. Hansen, Andrew R. Williams, Matthew Denwood, Peter Nejsum, Stig M. Thamsborg, Christian Friis   +5 more
doaj   +2 more sources

Dietary Inulin and Trichuris suis Infection Promote Beneficial Bacteria Throughout the Porcine Gut [PDF]

Frontiers in Microbiology, 2020
The gut microbiota (GM) displays a profound ability to adapt to extrinsic factors, such as gastrointestinal pathogens and/or dietary alterations. Parasitic worms (helminths) and host-associated GM share a long co-evolutionary relationship, exerting ...
Sophie Stolzenbach, Laura J. Myhill, Lee O’Brien Andersen, Lukasz Krych, Helena Mejer, Andrew R. Williams, Peter Nejsum, C. Rune Stensvold, Dennis S. Nielsen, Stig M. Thamsborg   +9 more
doaj   +2 more sources

A genetic analysis of Trichuris trichiura and Trichuris suis from Ecuador [PDF]

Parasites & Vectors, 2015
Background Since the nematodes Trichuris trichiura and T. suis are morphologically indistinguishable, genetic analysis is required to assess epidemiological cross-over between people and pigs.
Hayley Meekums, Mohamed BF Hawash, Alexandra M Sparks, Yisela Oviedo, Carlos Sandoval, Martha E Chico, J Russell Stothard, Philip J Cooper, Peter Nejsum, Martha Betson   +9 more
doaj   +2 more sources

Bacteria-induced egg hatching differs for Trichuris muris and Trichuris suis [PDF]

Parasites & Vectors, 2015
Background Eggs of the porcine whipworm Trichuris suis are currently explored in human clinical trials as a treatment of immune-mediated diseases. In this context, only the infective, embryonated eggs, constitute the Active Pharmaceutical Ingredient (API)
Nermina Vejzagić, Roberto Adelfio, Jennifer Keiser, Helene Kringel, Stig Milan Thamsborg, Christian M.O. Kapel   +5 more
doaj   +2 more sources

A survey of gastrointestinal helminth infestation in smallholder backyard pigs and the first molecular identification of the two zoonotic helminths Ascaris suum and Trichuris suis in Myanmar [PDF]

BMC Veterinary Research
Background Parasitic infestations have a substantial economic impact on pig production. This study aimed to investigate the gastrointestinal (GI) helminths in pigs and to molecularly characterise two important nematodes, Ascaris and Trichuris species ...
Saw Bawm, Lat Lat Htun, Hla Myet Chel, Yadanar Khaing, Myint Myint Hmoon, Su Su Thein, Shwe Yee Win, Nyein Chan Soe, Yu Nandi Thaw, Naoki Hayashi, Mar Mar Win, Nariaki Nonaka, Ken Katakura, Ryo Nakao   +13 more
doaj   +2 more sources

Influence of NOD2 Variants on Trichuris suis ova Treatment Outcome in Crohn’s Disease [PDF]

Frontiers in Pharmacology, 2018
A recent randomized study of whipworm Trichuris suis ova (TSO) in ileal Crohn’s disease failed to demonstrate a clinical benefit compared to placebo after 12 weeks.
Simon U. Jaeger, Simon U. Jaeger, Elke Schaeffeler, Elke Schaeffeler, Stefan Winter, Stefan Winter, Roman Tremmel, Roman Tremmel, Jürgen Schölmerich, Nisar Malek, Eduard F. Stange, Matthias Schwab, Matthias Schwab, Matthias Schwab, Matthias Schwab, Jan Wehkamp   +15 more
doaj   +2 more sources

Trichuris suis ova in inflammatory bowel disease-clinical challenges and translational pathways [PDF]

Frontiers in Immunology
This article reviews the mechanisms and clinical trial findings of Trichuris suis ova (TSO) for inflammatory bowel disease (IBD).The results show TSO may exert potential effects on IBD via multiple pathways, yet no significant efficacy has been confirmed
Su Zhou, Jiong Tang, Yu Wang
doaj   +2 more sources