Results 11 to 20 of about 2,329 (188)

Genome and transcriptome of the porcine whipworm Trichuris suis. [PDF]

Nat Genet, 2014
Trichuris (whipworm) infects 1 billion people worldwide and causes a disease (trichuriasis) that results in major socioeconomic losses in both humans and pigs. Trichuriasis relates to an inflammation of the large intestine manifested in bloody diarrhea, and chronic disease can cause malnourishment and stunting in children.
Jex AR, Nejsum P, Schwarz EM, Hu L, Young ND, Hall RS, Korhonen PK, Liao S, Thamsborg S, Xia J, Xu P, Wang S, Scheerlinck JP, Hofmann A, Sternberg PW, Wang J, Gasser RB.   +16 more
europepmc   +9 more sources

Uptake of benzimidazoles by Trichuris suis in vivo in pigs. [PDF]

Int J Parasitol Drugs Drug Resist, 2014
It is recognized that the clinical efficacy of single dose benzimidazoles (BZs) against the nematode, Trichuris suis of pigs and the closely related Trichuris trichiura in humans is only poor to moderate. Recent in vitro studies have indicated that a low uptake of fenbendazole (FBZ) in T. suis may be responsible for its poor efficacy.
Hansen TV, Friis C, Nejsum P, Olsen A, Thamsborg SM.   +4 more
europepmc   +5 more sources

Host age influence on the intensity of experimental Trichuris suis infection in pigs

Parasite, 2002
The impact of age-related resistance on the regulation of population dynamics of adult Trichuris suis was investigated in an experimental pig model. Helminth-naive pigs varying in age from five weeks to four years were infected with T.
Pedersen S., Saeed I.
doaj   +2 more sources

Trichuriasis in Human Patients from Côte d’Ivoire Caused by Novel Trichuris incognita Species with Low Sensitivity to Albendazole/Ivermectin Combination Treatment [PDF]

Emerging Infectious Diseases
Albendazole/ivermectin combination therapy is a promising alternative to benzimidazole monotherapy alone for Trichuris trichiura control. We used fecal DNA metabarcoding to genetically characterize Trichuris spp. populations in patient samples from Côte
Abhinaya Venkatesan, Rebecca Chen, Max Bär, Pierre H.H. Schneeberger, Brenna Reimer, Eveline Hürlimann, Jean T. Coulibaly, Said M. Ali, Somphou Sayasone, John Soghigian, Jennifer Keiser, John Stuart Gilleard   +11 more
doaj   +2 more sources

Multifunctional Thioredoxin-Like Protein from the Gastrointestinal Parasitic Nematodes Strongyloides ratti and Trichuris suis Affects Mucosal Homeostasis [PDF]

Journal of Parasitology Research, 2016
The cellular redox state is important for the regulation of multiple functions and is essential for the maintenance of cellular homeostasis and antioxidant defense.
Dana Ditgen, Emmanuela M. Anandarajah, Jan Hansmann, Dominic Winter, Guido Schramm, Klaus D. Erttmann, Eva Liebau, Norbert W. Brattig   +7 more
doaj   +2 more sources

The transcriptome of Trichuris suis--first molecular insights into a parasite with curative properties for key immune diseases of humans. [PDF]

PLoS ONE, 2011
BackgroundIatrogenic infection of humans with Trichuris suis (a parasitic nematode of swine) is being evaluated or promoted as a biological, curative treatment of immune diseases, such as inflammatory bowel disease (IBD) and ulcerative colitis, in humans.
Cinzia Cantacessi, Neil D Young, Peter Nejsum, Aaron R Jex, Bronwyn E Campbell, Ross S Hall, Stig M Thamsborg, Jean-Pierre Scheerlinck, Robin B Gasser   +8 more
doaj   +2 more sources

Genetic analysis of Trichuris suis and Trichuris trichiura recovered from humans and pigs in a sympatric setting in Uganda

Veterinary Parasitology, 2012
The whipworms Trichuris trichiura and Trichuris suis in humans and pigs, respectively, are believed to be two different species yet closely related. Morphologically, adult worms, eggs and larvae of the two species are indistinguishable. The aim of this study was to examine the genetic variation of Trichuris sp.
Nissen, Sofie, Al-Jubury, Azmi, Hansen, Tina Vicky Alstrup, Olsen, Annette, Christensen, Henrik, Thamsborg, Stig Milan, Nejsum, Peter   +6 more
openaire   +4 more sources

Immune and inflammatory responses in pigs infected with Trichuris suis and Oesophagostomum dentatum [PDF]

Veterinary Parasitology, 2015
The aim of the present study was to investigate parasite induced immune responses in pigs co-infected with Trichuris suis and Oesophagostomum dentatum as compared to mono-species infected pigs. T. suis is known to elicit a strong immune response leading to rapid expulsion, and a strong antagonistic effect on O. dentatum populations has been observed in
Annette Andreasen, Heidi H. Petersen, Helene Kringel, Tine M. Iburg, Kerstin Skovgaard, Harry Dawson, Joseph F. Urban, Stig M. Thamsborg   +7 more
openaire   +5 more sources

Trichuris Suis Terapi og Inflammatorisk Tarmsykdom

, 2014
Background In third world countries helminth infections are epidemic. The prevalence of inflammatory bowel disease is lower in these countries than in developed countries. This has lead scientists to explore the possibility that helminth infections may protect humans from inflammatory bowel disease and other autoimmune diseases.
Larsen, Tine Cecilie
openaire   +2 more sources

Experimental infection of pigs with three dose levels of Trichuris suis [PDF]

Parasite, 2000
The objective of the study was to follow the course of Trichuris suisinfection in pigs given infective eggs at low (400 eggs), medium (4,000 eggs) and high inoculation dose (40,000 eggs), respectively. Interestingly, despite a 100-fold difference in dose
Pedersen S., Saeed I.
doaj   +3 more sources