Results 41 to 50 of about 90,310 (310)

Functional principles of whisker-mediated touch perception

, 2015
In the progression of events wherein the rodent whisker sensory system constructs a percept of the world around the animal, neurons exercise distinct functional roles; here we review recent progress in our understanding of the principles for response ...
Diamond, Mathew Ernest, Maravall M, Maravall, M   +2 more
core   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Mechanical Attributes of Uniaxial Compression for Calcium Carbonate Whisker Reinforced Oil Well Cement Pastes

Advances in Materials Science and Engineering, 2017
It is crucial for design and safety of the cementing sheath to develop better understanding of the CaCO3 whisker reinforced oil well cement pastes. The uniaxial compression curve, mechanical constitutive relation, and reinforcing mechanism of the CaCO3 ...
Yuanyi Yang, Shun Fu, Xingkui Li
doaj   +1 more source

Whisker-mediated transformation of peanut with chitinase gene enhances resistance to leaf spot disease

, 2016
Peanut (Arachis hypogaea) is an important legume and oilseed crop, native to South America and grown in all tropical and temperate regions of the world.
Ghulam Muhammad Ali (12282581), Zahid Hussain Shah (5056130), Mahmood ul Hassan (12845341), Fahad Alghabari (12845347), Zahid Akram (12845344), Shaukat Ali (215701), Yusuf Zafar (564118)   +6 more
core   +1 more source

Whisker biomechanics in relation to whisker displacement.

, 2023
(A) Boxplot for the whisker length-base diameter ratio normalized by the mean lSO ratio. Ratios were arranged according to the semicircular configuration, which exhibited the lowest observed p-value with respect to a shuffled distribution for that ...
Ben Gerhardt (16503141), Miguel Concha-Miranda (6683318), Varun Sharma (4971478), Ana Rita Mendes (16503138), Matias Mugnaini (7795139), Dhruv Mehrotra (16503132), Michael Brecht (698823), Federico Davoine (16503135), Ann M. Clemens (16503144)   +8 more
core   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Effects of Adaptation on Discrimination of Whisker Deflection Velocity and Angular Direction in a Model of the Barrel Cortex

Frontiers in Computational Neuroscience, 2018
Two important stimulus features represented within the rodent barrel cortex are velocity and angular direction of whisker deflection. Each cortical barrel receives information from thalamocortical (TC) cells that relay information from a single whisker ...
Mainak J. Patel
doaj   +1 more source

Reducing Merkel cell activity in the whisker follicle disrupts cortical encoding of whisker movement amplitude and velocity

IBRO Neuroscience Reports, 2022
Merkel cells (MCs) and associated primary sensory afferents of the whisker follicle-sinus complex, accurately code whisker self-movement, angle, and whisk phase during whisking.
Clément E. Lemercier, Patrik Krieger
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Control of microstructure and mechanical properties of sintered aluminum nitride through addition of aluminum nitride whiskers

Journal of Asian Ceramic Societies, 2021
Aluminum nitride (AlN) usually exhibits a microstructure consisting of equiaxed grains. However, these grains do not allow for the positive control of the microstructure and mechanical properties of AlN.
Naoki Kondo, Akihiro Shimamura, Mikinori Hotta, Hiroki Shimizu, Toru Ujihara, Yoshihiro Ohnishi   +5 more
doaj   +1 more source