Results 41 to 50 of about 16,338 (281)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

open access: yesMolecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober   +16 more
wiley   +1 more source

The reintroduction of the white-tailed eagle to Ireland. Project report 2009 [PDF]

open access: yes, 2009
Nygård, T., Halley, D., & Mee, A. 2010 The reintroduction of the white-tailed eagle to Ireland. Project report 2009 - NINA Report 583. 30 pp. A programme to reintroduce the white tailed eagle Haliaeetus albicilla to Ireland, where the spe-cies became ...
Nygård, Torgeir   +2 more
core  

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Demographic patterns in winter carcass use by Golden Eagle and White-tailed Eagle in Finnmark, Norway [PDF]

open access: yes, 2012
The carcass use of juveniles, subadults and adults of the two eagle species in Norway, the White-tailed Eagle (Haliaeetus albicilla) and the Golden Eagle (Aquila chrysaetos) was studied in Finnmark, the northernmost county of Norway for two winters, in ...
Pálsdóttir, Elínborg Sædís
core  

Replacement of legend for Figure 1 appeared in The Journal of Poultry Science 52 (3): 167-175, 2015:

open access: yesThe Journal of Poultry Science, 2015
Fig. 1. Avian species designated as “nationally endangered species of wild fauna and flora” under the conservation and propagation programs.
doaj   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

open access: yesFEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji   +2 more
wiley   +1 more source

Survival, Nest Site Affiliation and Post-Fledging Movements of Danish White-Tailed Eagles (Haliaeetus albicilla)

open access: yesDiversity
The early life movement patterns of long-lived, large raptors, such as the white-tailed eagle (Haliaeetus albicilla), remain largely unexplored. In this study, we have tracked 22 individuals of white-tailed eagles hatched in Denmark to investigate key ...
Daniel Palm Eskildsen   +5 more
doaj   +1 more source

IN4MER Biomaterial Ink: A Phosphorescent Biosensing Biomaterial Ink for Multiple Analytes (Glucose, Lactate, Oxygen) Measurements and Temperature Sensing Applications

open access: yesAdvanced Functional Materials, EarlyView.
Multianalyte, real‐time monitoring of bioprinted scaffolds remains challenging. Phosphorescence‐lifetime–based, optically responsive microparticles are embedded in diverse printable hydrogels (κ‐carrageenan, GelMA, PEGDA) to form biomaterial inks that report oxygen, glucose, lactate, and temperature.
Waqas Saleem   +11 more
wiley   +1 more source

Hacking Techniques Improve Health and Nutritional Status of Nestling White-tailed Eagles

open access: yesEcology and Evolution, 2022
Birds of prey frequently feature in reintroductions and the hacking technique is typically used. Hacking involves removing large nestlings from donor populations, transferring them to captivity, feeding them ad libitum. Potentially, via the hacking method, stress of captivity and disruption of parental feeding may be detrimental.
Miguel Ferrer   +8 more
openaire   +5 more sources

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