Results 71 to 80 of about 16,338 (281)

PD‐1 Inhibits CD4+ TRM‐Mediated cDC1 Mobilization via Suppressing JAML in Human NSCLC

Advanced Science, EarlyView.
CD4+ tissue‐resident memory T cells (TRMs) in non‐small cell lung cancer recruit conventional type 1 dendritic cells via XCL1‐XCR1 signaling, orchestrating antitumor immunity. The costimulatory molecule JAML is essential for this process. PD‐1 blockade restores JAML expression and cDC1 mobilization, while JAML agonists synergize with anti‐PD‐1 therapy,
Zheyu Shao, Qinyuan Liu, Zhongwei Xin, Zhiyao Zhou, Mingjie Lin, Di Chen, Zhixing Hao, Yongyuan Chen, Wenxuan Wu, Shuyang Zhang, Xiaoke Chen, Xia Xu, Jinfan Li, Wei Lin, Yuhao Lu, Dang Wu, Pin Wu   +16 more
wiley   +1 more source

Public consultation report, white-tailed eagle project [PDF]

The aim of this study was to conduct a public consultation to evaluate public opinion regarding the ecological, economic and social impacts of a proposed white-tailed eagle (WTE) (Haliaeetus albicilla) re-introduction in Cumbria. The consultation was designed to support a licence application from Natural England for a Schedule 9 species by complying ...
Mayhew, Michael
openaire   +1 more source

Molecular approaches used to infer evolutionary history, taxonomy, population structure, and illegal trade of White-tailed Black-cockatoos (Calyptorhynchus spp.) in Australia

, 2011
Cockatoos are charismatic, iconic Australasian birds, yet this family (Cacatuidae) is inadequately understood from a genetic perspective. Herein, this thesis describes a detailed genetic study of endangered white-tailed black-cockatoos (WTBCs ...
White, Nicole
core  

Food of the white‐tailed eagle Haliaeetus albicilla in Greenland

Ecography, 1983
Six nests of white‐tailed eagles in the southernmost Greenland were watched during the nestling period and food items recorded photographically by remote controlled cameras. The species composition of the food was representative even for the adult eagles' diet. Fish made up a major part of 90%, various bird species and arctic fox pups the remaining 10%.
Frank Wille, Kaj Kampp
openaire   +1 more source

CDK4/6 Inhibition Induces CD8+ T Cell Antitumor Immunity via MIF‐Induced Functional Orchestration of Tumor‐Associated Macrophages

Advanced Science, EarlyView.
CDK4/6 inhibition promotes CD8+ T cell expansion through tumor‐macrophage crosstalk by activating HIF‐1α and enhancing MIF‐CD44/CD74 signaling. This reprograms TAMs to boost MHC‐I antigen presentation, and CDK4/6 inhibitor‐trained M1 TAM supernatant therapy synergizes with low‐dose PD‐1 blockade to restore antitumor immunity.
Lin He, Yuzhong Peng, Lat‐lun Leong, Jingbo Zhou, Dongyang Tang, Weilu Wang, Xiaoran Wu, Josh haipeng Lei, Yongqin Ye, Yangyang Feng, Yunfeng Qiao, Xiangpeng Chu, Di Mu, Qi Zhao, Tzuming Liu, Yan Chen, Paul Kwonghang Tam, Chu‐Xia Deng   +17 more
wiley   +1 more source

White-tailed eagles in time and space

, 2021
Áhrif stofnstærðarsveiflna á erfðabreytileika og hegðun breytileika í litlum stofnum hefur verið vel lýst. Fjölmargar rannsóknir í líffræði hafa verið gerðar á erfðabreytileika stofna en sjaldan hafa sýni verið greind fyrir og eftir slíkar niðursveiflur, sem kallaðar hafa verið erfðafræðilegur flöskuháls, og því eru áhrifin oft greind eftir ...
openaire   +1 more source

Seasonality of the White-Tailed Eagle in the Omsk Region, Russia

Raptors Conservation, 2014
Spring migration of the White-Tailed Eagle (Haliaeetus albicilla) within the Omsk region proceeds in a wide zone along the Irtysh river, in a North-North-Westerly direction.  In spring and early summer, established breeding pairs are distributed across the nesting sites in all climatic zones of the region from the steppes to the taiga; immature and ...
openaire   +3 more sources

GATA4‐Driven Transcription of HtrA1 Promotes Cellular Senescence in Ménière's Disease and Age‐Related Audio‐Vestibular Dysfunction

Advanced Science, EarlyView.
This study identifies the HDAC6/GATA4/HtrA1 axis as a critical driver of cellular senescence in the inner ear. GATA4 nuclear translocation, facilitated by HDAC6 downregulation, transcriptionally activates HtrA1, promoting hair cell senescence, SASP, and audio‐vestibular dysfunction in models of Ménière's disease and age‐related audio‐vestibular ...
Na Zhang, Na Li, Yan Wang, Jing Zhang, Jiahui Liu, Lei Chen, Yongdong Song, Yurong Mu, Yuechen Han, Yafeng Lyu, Xiaofei Li, Hanyue Wang, Jing Wang, Yao Lu, Zhaomin Fan, Daogong Zhang, Haibo Wang   +16 more
wiley   +1 more source

Conservation Genetics of the White-Tailed Eagle [Elektronisk resurs]

, 2006
The white-tailed eagle is a formerly threatened raptor that is commonly used as a flagship and indicator species in conservation work. This thesis uses molecular genetic methods to study sex determination of nestlings, genetic variability, population ...
Vilà, Carles, Fleischer, Rob C,, Hailer, Frank,, Ellegren, Hans   +3 more
core  

Natural Products Inspired Scaffold Diversification Leads to Unnatural Molecular Warhead and Covalent Strategy to Modulating Protein Function through Electrophilic Bromine Transfer

Advanced Science, EarlyView.
We report a new thiolate‐reactive α,α‐gem‐dibromo lactam warhead that activates transcription factor Nrf2 and demonstrates anti‐inflammatory activities, which have implications in cancer, neurodegeneration, and cardiovascular diseases. RNA‐seq illuminated detailed transcriptional profiles, and chemical reactions with cysteine‐containing compounds ...
Beau R. Brummel, Sofia Kokkaliari, Qiwen Gao, Jinjing Chen, Larissa Costa de Almeida, Srinivasarao Tenneti, Derek A. Leas, Eli Levit, Lewis S. Alexander, Khalil A. Abboud, Pingrong Wei, Michael D. Cameron, James R. Rocca, Ranjala Ratnayake, Donna D. Zhang, Hendrik Luesch, Robert W. Huigens III   +16 more
wiley   +1 more source