Results 121 to 130 of about 2,969,829 (393)

Unraveling Glucocorticoid Resistance In MLLrearranged Infant Acute Lymphoblastic Leukemia [PDF]

, 2014
__Abstract__ In the Netherlands, approximately 650 children aged between 0 and 18 years are diagnosed with cancer every year, including ~120 patients suffering from leukemia.
Hagelstein, J.A.P. (Jill)
core   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Elevated white blood cell counts and risk of metabolic syndrome: a dose-response meta-analysis

مجله علمی دانشگاه علوم پزشکی کردستان, 2019
Background and Aim: Elevated white blood cell count has been a known risk factor for cardiovascular diseases. Cardiometabolic diseases have some risk factors in common.
Roholla Hemmati, Sedighe Rastaghi, Mohammad Sarmadi, Zeinab Bidel, Wahideh Menati   +4 more
doaj  

DDX3X induces mesenchymal transition of endothelial cells by disrupting BMPR2 signaling

FEBS Open Bio, EarlyView.
Elevated DDX3X expression led to downregulation of BMPR2, a key regulator of endothelial homeostasis and function. Our co‐immunoprecipitation assays further demonstrated a molecular interaction between DDX3X and BMPR2. Notably, DDX3X promoted lysosomal degradation of BMPR2, thereby impairing its downstream signaling and facilitating endothelial‐to ...
Yu Zhang, Jing Wang, De‐Hui Qian, Yang‐Fan Lv, Tian‐Le Cheng, Da‐Peng Wang, Jing Zhang, Ye Fan   +7 more
wiley   +1 more source

Positive correlation of serum leptin with blood lymphocytes in maintenance hemodialysis patients [PDF]

, 2005
Objective: The objective of this study was to find the association of serum leptin with blood lymphocyte and polymorphonuclear (PMN) percentages as the markers of immune system function as well as nutritional status in maintenance hemodialysis patients ...
Baradaran, A., Nasri, H.
core  

Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276

FEBS Open Bio, EarlyView.
Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig, Swanhild Lohse, Sara Elahi, Nils Hartmann, Stefanie Deckert, Shutian Si, Alexander Desuki, Anja Harder   +7 more
wiley   +1 more source

Effect of Flow Water Velocity on Hematology Component in Improving Quality of Tiger Grouper Juvenile (Epinephelus Fuscoguttatus) [PDF]

, 2012
The flow water velocity is closely correlated to oxygen demand. Oxygen plays an important role as the indicator of fish blood. The objective of research is to acknowledge red blood cell, hematocrit, hemoglobin, and white blood cell of grouper larvae ...
am, A. (Aulanni'), Herawati, E. Y. (E), Ratoe Oedjoe, Marcelien Dj, Suprayitno, E. (E)   +3 more
core  

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

All-plastic, miniature, digital fluorescence microscope for three part white blood cell differential measurements at the point of care.

Biomedical Optics Express, 2015
Three-part differential white blood cell counts are used for disease diagnosis and monitoring at the point-of-care. A low-cost, miniature achromatic microscope was fabricated for identification of lymphocytes, monocytes, and granulocytes in samples of ...
Alessandra Forcucci, M. Pawlowski, Catherine E Majors, R. Richards-Kortum, T. Tkaczyk   +4 more
semanticscholar   +1 more source

Dementia and Primary-Care Health Measures:Hearing, Gait, and Markers of Inflammation [PDF]

, 2015
Dementia is a syndrome associated with declining cognitive function that has a variety of types and causes, and is encountered frequently in general medical practice. Researchers are actively exploring possible risk factors for dementia. The St.
Lindgren, Elsa
core   +1 more source