Results 51 to 60 of about 8,966,895 (251)

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Cytoskeletal protein 4.1R negatively regulates T-cell activation by inhibiting the phosphorylation of LAT

, 2009
Protein 4.1R (4.1R) was first identified in red cells where it plays an important role in maintaining mechanical stability of red cell membrane. 4.1R has also been shown to be expressed in T cells, but its function has been unclear. In the present study,
Hughes, Richard, Pei, Xinhong, Zhang, Xihui, Guo, Xinhua, Susanne Heck, Yu, Yu, Halverson, Gregory, Gregory Halverson, Richard Hughes, Narla Mohandas, Kang, Qiaozhen, Xiuli An, Xinhong Pei, Heck, Susanne, Xihui Zhang, An, Xiuli, Mohandas, Narla, Qiaozhen Kang, Yu Yu, Xinhua Guo   +19 more
core   +1 more source

White blood cell counts and neutrophil to lymphocyte ratio in the diagnosis of testicular cancer: a simple secondary serum tumor marker

International Brazilian Journal of Urology, 2016
Purpose The aim of the study was to investigate white blood cell counts and neutrophil to lymphocyte ratio (NLR) as markers of systemic inflammation in the diagnosis of localized testicular cancer as a malignancy with initially low volume.
Ozgur Haki Yuksel, Ayhan Verit, Aytac Sahin, Ahmet Urkmez, Fatih Uruc   +4 more
doaj   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

White blood cell count and hypertension [PDF]

Journal of Human Hypertension, 2006
Hypertension is a major global health problem and public-health challenge, demanding a vast proportion of health care resources directly and indirectly because of its high and increasing prevalence and the concomitant risks of cardiovascular and kidney disease, disability-adjusted life-years and mortality.1, 2 Various risk factors have been implicated ...
V J, Karthikeyan, G Y H, Lip
openaire   +2 more sources

Exploring the value of hybrid capture-based next-generation sequencing technology in the suspected diagnosis of bloodstream infections [PDF]

PeerJ
Background Determining the source of infection is significant for the treatment of bloodstream infections (BSI). The gold standard of blood infection detection, blood cultures, have low positive rates to meet clinical needs.
Xinyuan Liu, Zhitao Gan, Zengshun Lin, Xiaojun Lin, Jianying Yuan, Lili Rong, Jiachang Chen, Jun Liu, Yingzhen Li, Chaohui Hu   +9 more
doaj   +2 more sources

White Blood Cell Classification Using Multi-Attention Data Augmentation and Regularization

Big Data and Cognitive Computing, 2022
Accurate and robust human immune system assessment through white blood cell evaluation require computer-aided tools with pathologist-level accuracy. This work presents a multi-attention leukocytes subtype classification method by leveraging fine-grained ...
Nasrin Bayat, Diane D. Davey, Melanie Coathup, Joon-Hyuk Park   +3 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Lymphatic vascular morphogenesis in development, physiology, and disease [PDF]

, 2011
The lymphatic vasculature constitutes a highly specialized part of the vascular system that is essential for the maintenance of interstitial fluid balance, uptake of dietary fat, and immune response. Recently, there has been an increased awareness of the
Amélie Sabine, Petrova, T.V., Stefan Schulte-Merker, Sabine, A., Schulte-Merker, S., Petrova, T. V., Tatiana V. Petrova   +6 more
core   +3 more sources

Hematological changes of Anemia`s in Horses of Equestrian club in Baghdad

The Iraqi Journal of Veterinary Medicine, 2012
This study was conducted to know thehematological changes of anemia in horsesat equestrian club in Baghdad. Blood samples were collected from 151 horses of both sexes(74 male and 77 female) and different agesrandomly.
Faisal G. Habasha
doaj   +1 more source