Results 61 to 70 of about 8,966,895 (251)

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Definition of Drosophila hemocyte subsets by cell-type specific antigens. [PDF]

, 2007
We analyzed the heterogeneity of Drosophila hemocytes on the basis of the expression of cell-type specific antigens. The antigens characterize distinct subsets which partially overlap with those defined by morphological criteria.
Laurinyecz, Barbara, Gateff, Elisabeth, Hultmark, Dan, Zsámboki, János, Andó, I., Váczi, Balázs, Vilmos, Péter, Zsámboki, J., Márkus, Róbert, Andó, István, Kurucz, Éva, Márkus, R., Hultmark, D., Vilmos, P., Csorba, Kinga, Váczi, B., Éva Kurucz, I. Andó, D. Hultmark, B. Váczi, Elisabeth Gateff, P. Vilmos, R. Márkus, Barbara Laurinyecz, Kinga Csorba, J. Zsámboki   +25 more
core   +1 more source

White blood cell count in birds: evaluation of a commercially available method

BMC Veterinary Research, 2019
Background To conduct a hematological analysis of avian blood samples, standard automated cell counting is unreliable because all avian blood cells are nucleated.
Lea Carisch, Martina Stirn, Jean Michel Hatt, Karin Federer, Regina Hofmann-Lehmann, Barbara Riond   +5 more
doaj   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

Molecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh, Ji Yun Jang, Yoon Jeon, Gi‐Cheon Kim, Hwanho Lee, Jooyoung Lee, Ju‐Hwa Kim, Hakhyun Kim, Minjee Kim, Ho‐Keun Kwon, Ho Lee, Hyun Seok Kim   +11 more
wiley   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Early and extensive CD55 loss from red blood cells supports a causal role in malarial anaemia. [PDF]

, 2011
BACKGROUND\ud \ud Levels of complement regulatory proteins (CrP) on the surface of red blood cells (RBC) decrease during severe malarial anaemia and as part of cell ageing process.
Fried, Michal, Moses Gwamaka, Michal Fried, Duffy, Patrick E, Patrick E Duffy, Gwamaka, Moses, Gonzalo Domingo, Domingo, Gonzalo   +7 more
core   +1 more source

White Blood Cell Counts and Malaria [PDF]

The Journal of Infectious Diseases, 2005
White blood cells (WBCs) were counted in 4697 individuals who presented to outpatient malaria clinics in Maesod, Tak Province, Thailand, and Iquitos, Peru, between 28 May and 28 August 1998 and between 17 May and 9 July 1999. At each site and in each year, WBC counts in the Plasmodium falciparum-infected patients were lower than those in the Plasmodium
F Ellis, McKenzie, Wendy A, Prudhomme, Alan J, Magill, J Russ, Forney, Barnyen, Permpanich, Carmen, Lucas, Robert A, Gasser, Chansuda, Wongsrichanalai   +7 more
openaire   +2 more sources

The acute exercise response of peripheral blood mononuclear cells and their bioenergetic function in women with high and low systemic estradiol levels

Physiological Reports
Decrease in the systemic estradiol (E2) levels caused by menopause has been associated with an increased risk for cardiovascular disease. We have previously shown that E2 level is associated with the systemic response to an acute bout of endurance ...
Sira Karvinen, Emilia Lähteenmäki, Bettina Hutz, Hanna‐Kaarina Juppi, Jari E. Karppinen, Anna Kankaanpää, Maarit Lehti, Eija K. Laakkonen   +7 more
doaj   +1 more source

Fish red blood cells express immune genes and responses

Aquaculture and Fisheries, 2018
The erythrocytes or red blood cells (RBCs) and leucocytes or white blood cells (WBCs) are the most abundant cell types in the circulatory system of vertebrates. The RBCs are responsible for gas exchange while WBCs are solely involved with immunity.
Yawei Shen, Dan Wang, Jinliang Zhao, Xiaowu Chen   +3 more
doaj   +1 more source