Results 41 to 50 of about 1,149,254 (265)

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Broadband White‐Light‐Emitting Electrochemical Cells

Advanced Photonics Research, 2023
Emerging organic light‐emitting devices, such as light‐emitting electrochemical cells (LECs), offer a multitude of advantages but currently suffer from that most efficient phosphorescent emitters are based on expensive and rare metals.
Brando Adranno, Shi Tang, Veronica Paterlini, Volodymyr Smetana, Olivier Renier, Guillaume Bousrez, Ludvig Edman, Anja-Verena Mudring   +7 more
doaj   +1 more source

Underwater power compensated white light source based on synthetic white laser

Heliyon, 2023
The semiconductor white laser light source is used as a light source for underwater illumination. The required standard color temperature of white light is obtained at the underwater target surface.
Wei-Yu Cai, Zi-Qi Jiang, Xiao-Mei Liu, Hua Liu, Xiao-Juan Ma, Rong-Nian Tang, Xiang Li   +6 more
doaj   +1 more source

Absorption of white light in photoreceptors

Vision Research, 1998
The fraction F of incident light absorbed by a photoreceptor of length l has traditionally been given by F = 1 - e-kl, where k is the absorption coefficient of the photoreceptor. Unfortunately, this widely-used expression is incorrect for absorption of the type of light most common in natural scenes--broad spectrum "white" light--and significantly over-
Warrant, Eric J., Nilsson, Dan-E.
openaire   +2 more sources

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Effects of Different Light Qualities and Intensities of Blue Light on Flowering and Volatiles in Coriander (Coriandrum sativum)

Horticulturae
Coriander leaves are widely valued in cooking due to their rich nutrition and unique volatiles, and the flowers are also beneficial for oil extraction from seeds.
Joo Young Kim, Madelyn D. Gennaro, Keun Ho Cho, Joseph M. Patt, Thomas A. Colquhoun   +4 more
doaj   +1 more source

Diagnostic value of narrow-band imaging laryngoscopy combined with laryngopharyngeal reflux scale for laryngeal carcinoma and precancerous lesions

陆军军医大学学报, 2023
Objective To evaluate the value of narrow-band imaging (NBI) laryngoscopy combined with laryngopharyngeal reflux scale in the diagnosis of laryngeal malignant tumors and precancerous lesions.
LIU Jian, JIANG Zhendong, LAN Fazhang, HE Ya   +3 more
doaj   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Energy Transfer between Conjugated Colloidal Ga2O3 and CdSe/CdS Core/Shell Nanocrystals for White Light Emitting Applications

Nanomaterials, 2016
Developing solid state materials capable of generating homogeneous white light in an energy efficient and resource-sustainable way is central to the design of new and improved devices for various lighting applications.
Paul C. Stanish, Pavle V. Radovanovic
doaj   +1 more source