Results 61 to 70 of about 1,149,254 (265)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Tandem white organic light-emitting diodes stacked with two symmetrical emitting units simultaneously achieving superior efficiency/CRI/color stability

Nanophotonics, 2019
In this work, a series of three and four-color tandem white organic light-emitting diodes (WOLEDs) are developed by using the optimized charge generating unit (CGU) to connect two electroluminescence (EL) units with symmetrical emitting layers, in which ...
Miao Yanqin, Wei Xiaozhen, Gao Long, Wang Kexiang, Zhao Bo, Wang Zhongqiang, Zhao Bin, Wang Hua, Wu Yucheng, Xu Bingshe   +9 more
doaj   +1 more source

White light conical diffraction

Optics Express, 2013
Conical diffraction occurs when light is incident along the optic axis of a biaxial crystal. The light spreads out into a hollow cone inside the crystal, emerging as a hollow cylinder. The intensity distribution beyond the crystal is described using an adapted paraxial wave dispersion model.
BALLANTINE, KYLE EDWARD, MC CLOSKEY, DAVID, JENNINGS, BRIAN DAVID, LUNNEY, JAMES GERARD, DARCY, RONAN, DONEGAN, JOHN FRANCIS, EASTHAM, PAUL   +6 more
openaire   +3 more sources

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

FEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong, Yuhei Hosokawa, Lars Oliver Essen, Manuel Maestre‐Reyna   +3 more
wiley   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

White light in Road and Car lighting [PDF]

Proceedings of the 21st International Conference LIGHT SVĚTLO 2015, 2015
The article deals with the use of white light for car and road lighting. It starts with a basic investigation about brightness evaluation of different headlamps (H7, D2S, LED). The relevance of peripheral viewing for night time trafic is discussed in a second part.
Stephan Voelker, Sabine Raphael, Peter Raynham   +2 more
openaire   +1 more source

Versatile vector tools for efficient protein screening across multiple expression systems

FEBS Open Bio, EarlyView.
A unified vector toolkit enables rapid protein expression screening across E. coli, insect, and mammalian cells. A single primer pair amplifies the target gene, which is inserted into any vector via a standardized interface. This streamlined workflow eliminates repeated cloning steps, accelerating the identification of optimal expression conditions for
Zhimin Zhu, Yaqing Liu, Lei Qin, Feng Yu, Qisheng Wang, Yahui Liu   +5 more
wiley   +1 more source

A comparative study on the use of white light, black light 365 nm and 395 nm for screening mold on food surfaces [PDF]

Songklanakarin Journal of Science and Technology (SJST)
Mold contamination on food presents significant threats to food safety and public health, necessitating the detection and prevention of mold presence in food products to ensure their quality and safety. The study investigates the effectiveness of white
Aryn Kraiwattanapong, Athip Kraiwattanapong, Nitipan Promprasoeth, Orawin Luecha   +3 more
doaj  

Time‐restricted feeding prior to Mycobacterium tuberculosis infection reduces tissue CD4+ T cells with limited impact on bacterial clearance

FEBS Open Bio, EarlyView.
Time‐restricted feeding (TRF) in mice increased liver fatty acid oxidation and decreased fatty acid biosynthesis. These alterations persisted when TRF was discontinued and the host was infected with Mycobacterium tuberculosis. Pre‐exposure to TRF did not alter tissue (lung and spleen) mycobacterial burden but significantly reduced CD3+ T cells in lungs
Ashish Gupta, Nidhi Yadav, Subhasmita Das, R. Rajendra Kumar Reddy, Nupur Sharma, Amol Ratnakar Suryawanshi, Jaswinder Singh Maras, Ranjan Kumar Nanda   +7 more
wiley   +1 more source