Results 121 to 130 of about 6,982,631 (374)

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source

Fast Radio Burst Tomography of the Unseen Universe [PDF]

, 2019
The discovery of Fast Radio Bursts (FRBs) at cosmological distances has opened a powerful window on otherwise unseen matter in the Universe. In the 2020s, observations of $>10^{4}$ FRBs will assess the baryon contents and physical conditions in the hot ...
Battaglia, Nicholas, Burke-Spolaor, Sarah, Chatterjee, Shami, Cordes, James, Hallinan, Gregg, Law, Casey, Lazio, T. Joseph W., Masui, Kiyoshi, McQuinn, Matthew, Munoz, Julian B., Palliyaguru, Nipuni, Prochaska, J. Xavier, Ravi, Vikram, Seymour, Andrew, Vedantham, Harish, Zheng, Yong   +15 more
core   +2 more sources

Influences of amyloid-β and tau on white matter neurite alterations in dementia with Lewy bodies

npj Parkinson's Disease
Dementia with Lewy bodies (DLB) is a neurodegenerative condition often co-occurring with Alzheimer’s disease (AD) pathology. Characterizing white matter tissue microstructure using Neurite Orientation Dispersion and Density Imaging (NODDI) may help ...
Elijah Mak, Robert I. Reid, Scott A. Przybelski, Timothy G. Lesnick, Christopher G. Schwarz, Matthew L. Senjem, Sheelakumari Raghavan, Prashanthi Vemuri, Clifford R. Jack, Hoon Ki Min, Manoj K. Jain, Toji Miyagawa, Leah K. Forsberg, Julie A. Fields, Rodolfo Savica, Jonathan Graff-Radford, David T. Jones, Hugo Botha, Erik K. St. Louis, David S. Knopman, Vijay K. Ramanan, Dennis W. Dickson, Neill R. Graff-Radford, Tanis J. Ferman, Ronald C. Petersen, Val J. Lowe, Bradley F. Boeve, John T. O’Brien, Kejal Kantarci   +28 more
doaj   +1 more source

Developmental Outcome of Very Preterm Infants at Adolescence Correlated with Grey and White Matter Abnormalities on MRI

Pediatric Neurology Briefs, 2008
MRI data of brains of 218 adolescents (ages 14-15 years) born very preterm, < 33 weeks gestation (VPT), and 128 controls bom at term were compared, using voxel-based morphometry, and the findings correlated with neurodevelopmental outcome in a study at ...
J Gordon Millichap
doaj   +1 more source

White matter from fibroblasts [PDF]

Nature Biotechnology, 2013
Myelinating oligodendrocytes are induced from murine embryonic fibroblasts by transcription factor–mediated reprogramming.
openaire   +2 more sources

Socioeconomic status, white matter, and executive function in children

Brain and Behavior, 2016
A growing body of evidence links socioeconomic status (SES) to children's brain structure. Few studies, however, have specifically investigated relations of SES to white matter structure.
A. Ursache, Kimberly G Noble
semanticscholar   +1 more source

DDX3X induces mesenchymal transition of endothelial cells by disrupting BMPR2 signaling

FEBS Open Bio, EarlyView.
Elevated DDX3X expression led to downregulation of BMPR2, a key regulator of endothelial homeostasis and function. Our co‐immunoprecipitation assays further demonstrated a molecular interaction between DDX3X and BMPR2. Notably, DDX3X promoted lysosomal degradation of BMPR2, thereby impairing its downstream signaling and facilitating endothelial‐to ...
Yu Zhang, Jing Wang, De‐Hui Qian, Yang‐Fan Lv, Tian‐Le Cheng, Da‐Peng Wang, Jing Zhang, Ye Fan   +7 more
wiley   +1 more source

Evaluation of brain white matter changes on MRI in patients newly diagnosed with obstructive sleep apnea compared with the control group

The Egyptian Journal of Bronchology
Background Obstructive sleep apnea (OSA) is nowadays introduced as a risk factor for white matter brain changes. Research on OSA and white matter changes provides contradictory evidence for the contextual link between the two conditions. This study aimed
Farzaneh Khoroushi, Yasmin Davoodi, Amirhossein Fathabadi, Reihane Bakhshi, Yasamin Sharifian, Maryam Salehi, Leila Ghofranyha, Ehsan Hassannejad, Farnaz Kharaghani   +8 more
doaj   +1 more source

Cortical thinning and microstructural integrity disruption in white matter hyperintensities

Brain Research Bulletin
Background: The relationships between white matter microstructure, cortical atrophy, and cognitive function in cerebral small vessel disease (CSVD)-related white matter hyperintensities (WMHs) patients are unclear. Methods: 71 right-handed WMHs patients (
Xin Wang, Jie Hu, Xiaosan Wu, Wei Wang, Xiaohui Xie, Shanshan Cao, Feng Geng, Panpan Hu, Yanghua Tian, Kai Wang, Jun Zhang   +10 more
doaj   +1 more source

P‐181: Differential regional relationships between cardiorespiratory fitness, arterial elasticity and white matter volume in normal aging and early Alzheimer's disease [PDF]

, 2007
George Thomas, William M. Brooks, Cary R. Savage, Lee Graves, Jeffrey M. Burns   +4 more
openalex   +1 more source