Results 101 to 110 of about 619,697 (299)

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Episodic memory function is associated with multiple measures of white matter integrity in cognitive aging

Frontiers in Human Neuroscience, 2012
Previous neuroimaging research indicates that white matter injury and integrity, measured respectively by white matter hyperintensities (WMH) and fractional anisotropy (FA) obtained from diffusion tensor imaging, differ with aging and cerebrovascular ...
Samuel Neal Lockhart, Samuel Neal Lockhart, Samuel Neal Lockhart, Adriane B. V. Mayda, Adriane B. V. Mayda, Adriane B. V. Mayda, Alexandra E. Roach, Alexandra E. Roach, Alexandra E. Roach, Evan eFletcher, Evan eFletcher, Owen eCarmichael, Owen eCarmichael, Pauline eMaillard, Pauline eMaillard, Christopher G. Schwarz, Christopher G. Schwarz, Andrew P. Yonelinas, Andrew P. Yonelinas, Charan eRanganath, Charan eRanganath, Charles eDeCarli, Charles eDeCarli, Charles eDeCarli, Charles eDeCarli   +24 more
doaj   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Cortical thinning and microstructural integrity disruption in white matter hyperintensities

Brain Research Bulletin
Background: The relationships between white matter microstructure, cortical atrophy, and cognitive function in cerebral small vessel disease (CSVD)-related white matter hyperintensities (WMHs) patients are unclear. Methods: 71 right-handed WMHs patients (
Xin Wang, Jie Hu, Xiaosan Wu, Wei Wang, Xiaohui Xie, Shanshan Cao, Feng Geng, Panpan Hu, Yanghua Tian, Kai Wang, Jun Zhang   +10 more
doaj   +1 more source

Developmental Outcome of Very Preterm Infants at Adolescence Correlated with Grey and White Matter Abnormalities on MRI

Pediatric Neurology Briefs, 2008
MRI data of brains of 218 adolescents (ages 14-15 years) born very preterm, < 33 weeks gestation (VPT), and 128 controls bom at term were compared, using voxel-based morphometry, and the findings correlated with neurodevelopmental outcome in a study at ...
J Gordon Millichap
doaj   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source

Prognostic Impact of European LeukemiaNet Genetic Risk Stratification System in Adult Patients With Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
This study aimed to evaluate the prognostic value of ELN2017 in predicting survival outcomes and to assess the impact of clinical and molecular factors such as age, FLT3 and NPM1 mutations, and allogeneic hematopoietic stem cell transplantation (allo‐HSCT).
Mobina Shrestha, Bishwas Mandal, Vishal Mandal, Asis Shrestha, Amir Babu Shrestha   +4 more
wiley   +1 more source

Risk Prediction Models for Recurrence After Curative Treatment of Early‐Stage or Locally Advanced Lung Cancer: A Systematic Review

Aging and Cancer, EarlyView.
This systematic review synthesizes prognostic models for survival and recurrence in resected non‐small cell lung cancer. While many models demonstrate moderate to good discrimination, few are externally validated and reporting quality is variable, limiting clinical applicability and highlighting the need for robust, transparent model development ...
Evangeline Samuel, S. Tissera, E. Paul, J. Zalcberg, R. G. Stirling   +4 more
wiley   +1 more source