Results 101 to 110 of about 5,567,921 (295)

Probabilistic Clustering and Shape Modelling of White Matter Fibre Bundles using Regression Mixtures [PDF]

We present a novel approach for probabilistic clustering of white matter fibre pathways using curve-based regression mixture modelling techniques in 3D curve space. The clustering algorithm is based on a principled method for probabilistic modelling of a
Hojjatoleslami, Ali, Ratnarajah, Nagulan, Davydov, Oleg, Simmons, Andy   +3 more
core  

The C‐terminal truncated splicing variant of NK1R negatively modulates substance P‐stimulated NK1R signaling

FEBS Open Bio, EarlyView.
The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen, Duc Trung Nguyen, Minyoung Cho, Jihun Kim, Soyeon In, Thai Uy Nguyen, Sunghoon Hurh, Beom Jin Park, Jong‐Ik Hwang   +8 more
wiley   +1 more source

MARK4 enhances stress granule formation under oxidative stress and increases tau accumulation

FEBS Open Bio, EarlyView.
MARK4 (red dots) localizes to stress granules (orange dots) and promotes their formation under oxidative stress by modulating TIA1 (blue dots). MARK4 and TIA1 synergistically increase tau (purple) accumulation, and the reduction of the TIA1 ortholog suppresses neurodegeneration in a fly model.
Sho Nakajima, Kotone Watanabe, Grigorii Sultanakhmetov, Aoi Fukuchi, Keiya Ito, Sawako Shimizu, Taro Saito, Akiko Asada, Kanae Ando   +8 more
wiley   +1 more source

Evaluating GenAI‐produced feedback on undergraduate bioscience essays against good higher education feedback practice

FEBS Open Bio, EarlyView.
This pilot study investigates the potential of Generative AI to provide formative feedback to students. ChatGPT was prompted to provide feedback on Year 1 Bioscience essays, which were evaluated against established good feedback practices. GenAI‐authored feedback had useful elements, but was limited in scope. GenAI may have potential to provide instant,
Annabel Court, Nigel Francis, Andrew Shore, Stephen Rutherford   +3 more
wiley   +1 more source

Portrait of Glenn Murcutt, 1983 [picture] /

, 1983
Title from inscription on reverse.; Condition: Good.; Inscription: "Portrait of Glen [i.e. Glenn] Murcutt, 1983.
White, Jill.
core  

Selective elimination of quiescent cancer cells by dequalinium chloride via ROS‐mediated ferroptosis

FEBS Open Bio, EarlyView.
Dequalinium chloride (DQ) selectively eliminates quiescent cancer cells (QCCs) by amplifying mitochondrial ROS. QCCs exhibit elevated basal ROS and limited redox‐buffering capacity, making them vulnerable to further ROS increases. DQ‐induced ROS exceeds the tolerance threshold, triggering lipid peroxidation and ferroptosis, whereas proliferating cells ...
Kotaro Miyamoto, Shiori Sakai, Minori Endo, Terigele, Mizuho Niibori, Taiki Morita, Yu Goto, Arisa Yoshida, Tomohiro Tanaka, Ning Lin, Takahiro Kuchimaru, Hiroyuki Nakamura, Masahiro Inoue, Shinae Kizaka‐Kondoh, Tetsuya Kadonosono   +14 more
wiley   +1 more source

Spatio-temporal analysis of white matter in glioma from magnetic resonance imaging data: functional tensor and latencies

reservedRecently, white matter functional analysis has gained relevance, showing links to cerebral activity. Some brain diseases preferentially disrupt white matter, leading to pathological alterations in structure and function: glioma is one of them ...
ALAMPI, SARA
core  

Grant Mudford with Max Dupain in Artarmon Studio, 1990 [picture] /

, 1990
Title from inscription on reverse.; Condition: Good.; Inscription: "Grant Mudford with Max Dupain in Artarmon Studio, 1990.
White, Jill.
core  

Determinants of undergraduate bioscience engagement: Validating attendance barriers and classroom spatial behaviour across institutions

FEBS Open Bio, EarlyView.
Student engagement extends beyond simple attendance. Across 891 bioscience students from three universities, attendance behaviour was associated mainly with structural influences, whereas classroom spatial behaviour reflected affective and sensory factors.
Nigel Page, Rachel J. Hunt, Lauren J. Albee, Daniel Berwick, Alison Snape   +4 more
wiley   +1 more source

Association between white matter hyperintensities and gray matter volume in cerebral small vessel disease: insights from periventricular and deep white matter lesions

Frontiers in Neurology
ObjectiveTo investigate the relationship between the severity of periventricular white matter hyperintensities (PWMH) and deep white matter hyperintensities (DWMH) and gray matter volume in cerebral small vessel disease (CSVD) patients.MethodsClinical ...
Weishun Feng, Xinjun Lei, Shida Xu, Zhihua Xu   +3 more
doaj   +1 more source