Results 91 to 100 of about 619,697 (299)

White matter lesions and intra-arterial thrombolysis [PDF]

, 2012
The aim of the study was to assess the influence of white matter lesions in patients with acute ischemic stroke treated with intra-arterial thrombolysis (IAT). From September 2003 to January 2010, we treated 400 patients with IAT at our institution.
Galimanis, Aekaterini, Arnold, Marcel, Jung, Simon, Ballinari, Pietro, Fischer, Urs, Gralla, Jan, Schroth, Gerhard, De Marchis, Gian Marco, Brekenfeld, Caspar, Weck, Anja, El-Koussy, Marwan, Findling, Oliver, Mattle, Heinrich P, Mono, Marie Luise   +13 more
core   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

White matter and literacy: A dynamic system in flux

Developmental Cognitive Neuroscience
Cross-sectional studies have linked differences in white matter tissue properties to reading skills. However, past studies have reported a range of, sometimes conflicting, results. Some studies suggest that white matter properties act as individual-level
Ethan Roy, Adam Richie-Halford, John Kruper, Manjari Narayan, David Bloom, Pierre Nedelec, Andreas M. Rauschecker, Leo P. Sugrue, Timothy T. Brown, Terry L. Jernigan, Bruce D. McCandliss, Ariel Rokem, Jason D. Yeatman   +12 more
doaj   +1 more source

Robust automated detection of microstructural white matter degeneration in Alzheimer’s disease using machine learning classification of multicenter DTI data

, 2013
Diffusion tensor imaging (DTI) based assessment of white matter fiber tract integrity can support the diagnosis of Alzheimer’s disease (AD). The use of DTI as a biomarker, however, depends on its applicability in a multicenter setting accounting for ...
Thomas Kirste, Stefan J. Teipel (417223), Stefan J. Teipel, Fellgiebel, Andreas, Karlheinz Hauenstein (417221), Hauenstein, K., Kilimann, I., Harald Hampel, Thomas Kirste (417222), Dyrba, M., Kirste, Thomas, Bokde, A.L.W., Kilimann, Ingo, Annahita Oswald, Pievani, M., Filippi, M., Martin Dyrba (417214), Ewers, Michael, Martin Wegrzyn, Hauenstein, Karlheinz, Ewers, M., Klöppel, Stefan, Arun L. W. Bokde (206207), Pievani, Michela, Oswald, Annahita, Michela Pievani, EDSD, [Study group], Claudia Plant, Klöppel, S., Karlheinz Hauenstein, Andreas Fellgiebel, Michael Ewers (317132), Massimo Filippi, Thomas Meindl, Arun L W Bokde, Martin Dyrba, Plant, C., Wegrzyn, Martin, Teipel, Stefan, Thomas Meindl (417219), Massimo Filippi (110054), Filippi, Massimo, Claudia Plant (417217), Bokde, Arun L. W., Wegrzyn, M., Kirste, T., Hampel, Harald, Andreas Fellgiebel (382233), Stefan Klöppel (261558), Annahita Oswald (417218), Arun L. W. Bokde, EDSD study group, Meindl, Thomas, Michael Ewers, Ingo Kilimann, EDSD Study Group (), Martin Wegrzyn (417215), Stefan Klöppel, Stefan J Teipel, Michela Pievani (417220), Hampel, H., Plant, Claudia, Harald Hampel (183230), Oswald, A., Teipel, Stefan J., Meindl, T., Teipel, S.J., Ingo Kilimann (417216), Fellgiebel, A., Dyrba, Martin   +69 more
core   +1 more source

Clinical Significance of White Matter Lesions in Idiopathic Sudden Sensorineural Hearing Loss

, 2022
Background : We aimed to analyze the patient characteristics in accordance with white matter lesions and confirm whether white matter lesions affect final treatment outcomes in idiopathic sudden sensorineural hearing loss. Methods: Medical records of 126
Sung Wan Wan Byun, Min Woo Kim, Wan Byun, Sung, Soo Jin Kim, In Kyu Yu, Jin Kim, Soo, Woo Kim, Min, Seung-Ho Shin, Shin, Seung-Ho, Kyu Yu, In, Ho Yun Lee, Yun Lee, Ho   +11 more
core   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

MiR‐513a promotes human erythroid differentiation by modulating c‐Jun

FEBS Open Bio, EarlyView.
During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim, Brittany Taylor, Shannon Bolten, Christian L. Eberly, Mahliya Abdurahman, T. Michael Creed, Acong Yang, Taylor L. Hatchet, Tristan Dyson, Shuo Gu, Curt I. Civin, Tami J. Kingsbury   +11 more
wiley   +1 more source

Lnc_011797 promotes ferroptosis and aggravates white matter lesions

Neural Regeneration Research
Recent evidence suggests that ferroptosis plays a crucial role in the occurrence and development of white matter lesions. However, the mechanisms and regulatory pathways involved in ferroptosis within white matter lesions remain unclear.
Xiang Xu, Yu Sun, Xiaoyan Zhu, Shiyin Ma, Jin Wei, Chang He, Jing Chen, Xudong Pan   +7 more
doaj   +1 more source

Influence of white matter inhomogeneous anisotropy on EEG forward computing [PDF]

, 2008
In this paper, we model the human head using the Volume and Wang’s constraint methods, and study the inhomogeneous anisotropic conductivity for white matter (WM) using finite element method (FEM).
Bashar, R., Wen, P., Li, Y.
core   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source