Results 71 to 80 of about 5,007,319 (296)

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Childhood Adversity and White Matter Microstructure: White Matter Differences Associated with Trauma Exposure

Stresses
Current research on the effects of childhood trauma largely focuses on maltreatment. In the current study, we used diffusion tensor imaging (DTI) to determine the association between potentially traumatic exposures not related to maltreatment and ...
Andrea Rodriguez, Helen Petropoulos, Pilar M. Sanjuan, Yu-Ping Wang, Tony W. Wilson, Vince D. Calhoun, Julia M. Stephen   +6 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Individual Differences in True and False Memory Retrieval Are Related to White Matter Brain Microstructure [PDF]

, 2013
We sometimes vividly remember things that did not happen, a phenomenon with general relevance, not only in the courtroom. It is unclear to what extent individual differences in false memories are driven by anatomical differences in memory-relevant brain ...
Rodríguez Fornells, Antoni, Krämer, Ulrike M., Fuentemilla Garriga, Lluís, Marco Pallarés, Josep, Münte, Thomas F., Càmara, Estela, Cunillera, Toni, Tempelmann, Claus   +7 more
core   +4 more sources

Region Specific miRNA-mRNA Networks in Gray and White Matter Lesions of Progressive Multiple Sclerosis. [PDF]

Ann Clin Transl Neurol
ABSTRACT Objective Multiple sclerosis (MS) is a neurodegenerative demyelinating disease of the central nervous system. This study aimed to identify micro‐RNA (miRNA)–mRNA regulatory networks underlying region‐specific molecular mechanisms in white matter and gray matter lesions in progressive MS.
Sapra A, Rai NK, Niepokny TD, Courtney H, Tripathi A, Dutta R.   +5 more
europepmc   +2 more sources

White Matter Microstructural Abnormalities in Neonatal Onset Genetic Epilepsy. [PDF]

Ann Clin Transl Neurol
ABSTRACT Objective Recent evidence indicates that epilepsy is associated with abnormal white matter. If seizures alter white matter, then the impact upon network function, epileptogenesis, and cognition could be pronounced in neonates undergoing rapid developmental myelination. Neonates with epilepsy due to nonstructural genetic causes provide a unique
Sandoval Karamian AG, Zhu T, Huang H, Massey SL, Fitzgerald MP, Parikh D, Vossough A, Helbig I, Abend NS.   +8 more
europepmc   +2 more sources

Regional distribution of white matter hyperintensities in vascular dementia, Alzheimer's disease and healthy aging [PDF]

, 2004
Background: White matter hyperintensities (WMH) on MRI scans indicate lesions of the subcortical fiber system. The regional distribution of WMH may be related to their pathophysiology and clinical effect in vascular dementia (VaD), Alzheimer's disease ...
Zebuhr, Y, Teipel, S. J., Möller, H. J., Zebuhr, Y., Leinsinger, G., Teipel, SJ, Gootjes, Liselotte, Wismüller, A., Hampel, H, Teipel, S.J, Scheltens, P, Schwarz, R., Scheltens, P., Möller, Hans-Jürgen, Gootjes, L., Wismuller, A, Hampel, H., Moller, HJ, Möller, H.-J., Leinsinger, G, Schwarz, R   +20 more
core   +2 more sources

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Spatial coupling of enlarged perivascular spaces and white matter lesions across the Alzheimer's disease continuum

Frontiers in Neuroscience
IntroductionEmerging evidence suggests that impaired waste-clearance systems contribute to Alzheimer's disease pathogenesis, yet the etiology of clearance dysfunction markers, such as enlarged perivascular spaces, remains unclear.
Serena Tang, Serena Tang, Pamela Thropp, Isabella Hausle, Kyan Younes, Duygu Tosun, Duygu Tosun   +6 more
doaj   +1 more source

White matter matters: a multimodal approach to investigate white matter microstructure and metabolism

, 2014
White matter connects different brain areas and applies electrical insulation to the neuron’s axons with myelin sheaths in order to enable quick signal transmission.
Giezendanner, Stéphanie
core