Results 71 to 80 of about 619,697 (299)

Ubiquitination of secretory granules promotes their crinophagic degradation in Drosophila

FEBS Letters, EarlyView.
Ubiquitination of secretory granules in Drosophila larval salivary glands is a critical molecular trigger for crinophagy, the lysosomal degradation of unreleased, or low‐quality granules. The E3 ubiquitin ligase Cnot4 is recruited to the surface of secretory granules to induce crinophagy.
Tamás Csizmadia, Anna Dósa, Asha Kiran Maddali, András Jipa, Hajnalka Laczkó‐Dobos, Péter Lőw, Gábor Juhász   +6 more
wiley   +1 more source

Compression analysis of the gray and white matter of the spinal cord

Neural Regeneration Research, 2020
The spinal cord is composed of gray matter and white matter. It is well known that the properties of these two tissues differ considerably. Spinal diseases often present with symptoms that are caused by spinal cord compression.
Norihiro Nishida, Fei Jiang, Junji Ohgi, Akihiro Tanaka, Yasuaki Imajo, Hidenori Suzuki, Masahiro Funaba, Takashi Sakai, Itsuo Sakuramoto, Xian Chen   +9 more
doaj   +1 more source

The effect of N-acetyl-aspartyl-glutamate and N-acetyl-aspartate on white matter oligodendrocytes

, 2009
Elevations of the levels of N-acetyl-aspartyl-glutamate (NAAG) and N-acetyl-aspartate (NAA) are associated with myelin loss in the leucodystrophies Canavan's disease and Pelizaeus-Merzbacher-like disease. NAAG and NAA can activate and antagonize neuronal
Attwell, D., Koodziejczyk, Karolina, Kolodziejczyk, K., Wade, A., Kradttir, Ragnhildur, Wade, Anna, Karadottir, R., Hamilton, Nicola B.; id_orcid, Attwell, David, Hamilton, N. B.   +9 more
core   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Childhood Adversity and White Matter Microstructure: White Matter Differences Associated with Trauma Exposure

Stresses
Current research on the effects of childhood trauma largely focuses on maltreatment. In the current study, we used diffusion tensor imaging (DTI) to determine the association between potentially traumatic exposures not related to maltreatment and ...
Andrea Rodriguez, Helen Petropoulos, Pilar M. Sanjuan, Yu-Ping Wang, Tony W. Wilson, Vince D. Calhoun, Julia M. Stephen   +6 more
doaj   +1 more source

Nonparenchymal fluid is the source of increased mean diffusivity in preclinical Alzheimer's disease

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, 2019
Introduction Although increased mean diffusivity of the white matter has been repeatedly linked to Alzheimer's disease pathology, the underlying mechanism is not known.
Farshid Sepehrband, Ryan P. Cabeen, Giuseppe Barisano, Nasim Sheikh‐Bahaei, Jeiran Choupan, Meng Law, Arthur W. Toga, Alzheimer's Disease Neuroimaging Initiative   +7 more
doaj   +1 more source

Bayesian model selection for pathological neuroimaging data applied to white matter lesion segmentation.

, 2015
In neuroimaging studies, pathologies can present themselves as abnormal intensity patterns. Thus, solutions for detecting abnormal intensities are currently under investigation.
Willem H. Bouvy, Sudre, Carole H., Bouvy, W, Josephine Barnes, Biessels, G, Biessels, Geert Jan, Barnes, Josephine, Sudre, C, Ourselin, Sebastien, Bouvy, Willem H., Sebastien Ourselin, Cardoso, MJ, Ourselin, S, M. Jorge Cardoso, Geert Jan Biessels, Cardoso, M. Jorge, Barnes, J, Sudre, Carole H.; id_orcid, Cardoso, M. Jorge; id_orcid, Carole H. Sudre   +19 more
core   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Considerations for the optimization of induced white matter injury preclinical models

Frontiers in Neurology, 2015
The white matter injury in relation to acute neurologic conditions, especially stroke, has remained obscure until recently. Current advances in the imaging technologies in the field of stroke have confirmed that white matter injury plays an important ...
Abdullah Shafique Ahmad, Irawan eSatriotomo, Jawad eFazal, Stephen eNadeau, Stephen eNadeau, Sylvain eDoré, Sylvain eDoré   +6 more
doaj   +1 more source

White matter matters: a multimodal approach to investigate white matter microstructure and metabolism

, 2014
White matter connects different brain areas and applies electrical insulation to the neuron’s axons with myelin sheaths in order to enable quick signal transmission.
Giezendanner, Stéphanie
core