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Spatial coupling of enlarged perivascular spaces and white matter lesions across the Alzheimer's disease continuum [PDF]

Frontiers in Neuroscience
IntroductionEmerging evidence suggests that impaired waste-clearance systems contribute to Alzheimer's disease pathogenesis, yet the etiology of clearance dysfunction markers, such as enlarged perivascular spaces, remains unclear.
Serena Tang, Serena Tang, Pamela Thropp, Isabella Hausle, Kyan Younes, Duygu Tosun, Duygu Tosun   +6 more
doaj   +2 more sources

Role of disturbed structural connectivity network in patients with white matter lesions and cognitive impairment revealed by diffusion-tensor magnetic resonance imaging [PDF]

Journal of International Medical Research
Objective This study aimed to compare small-world network attributes between control participants without memory complaints and patients with white matter lesions showing cognitive impairment.
Xiaojin Ning, Min Wu, Jianjun Tan, Meina Feng, Qin Zhou, Zhimin Fan, Ling Wan, Li Zhang, Jinfang Wang   +8 more
doaj   +2 more sources

Lnc_011797 promotes ferroptosis and aggravates white matter lesions [PDF]

Neural Regeneration Research
Recent evidence suggests that ferroptosis plays a crucial role in the occurrence and development of white matter lesions. However, the mechanisms and regulatory pathways involved in ferroptosis within white matter lesions remain unclear.
Xiang Xu, Yu Sun, Xiaoyan Zhu, Shiyin Ma, Jin Wei, Chang He, Jing Chen, Xudong Pan   +7 more
doaj   +2 more sources

Incidence and Risk Factors of White Matter Lesions in Moderate and Late Preterm Infants [PDF]

Diagnostics
Background: Moderate and late preterm infants (32–36 weeks of gestation) are at significant risk of developmental impairments. Incidence of white matter lesions, which are associated with developmental impairments in very preterm infants, remains ...
Kentaro Ueda, Kennosuke Tsuda, Takaharu Yamada, Shin Kato, Sachiko Iwata, Shinji Saitoh, Osuke Iwata   +6 more
doaj   +2 more sources

Type I collagen secreted in white matter lesions inhibits remyelination and functional recovery [PDF]

Cell Death and Disease
White matter injury is caused by cerebral blood flow disturbances associated with stroke and demyelinating diseases such as multiple sclerosis. Remyelination is induced spontaneously after white matter injury, but progressive multiple sclerosis and white
Reiji Yamazaki, Morio Azuma, Yasuyuki Osanai, Tom Kouki, Takeshi Inagaki, Akiyoshi Kakita, Masaki Takao, Nobuhiko Ohno   +7 more
doaj   +2 more sources

Changes in Normal-Appearing White Matter Precede Development of White Matter Lesions [PDF]

Stroke, 2013
Background and Purpose— It is unknown whether white matter lesions (WML) develop abruptly in previously normal brain areas, or whether tissue changes are already present before WML become apparent on MRI. We therefore investigated whether development of WML is preceded by quantifiable changes in normal-appearing white matter ...
Marius De Groot, Benjamin F J Verhaaren, Renske De Boer   +2 more
exaly   +3 more sources

White Matter Lesions and Cognitive Impairment as Silent Cerebral Disease in Hypertension

The Scientific World Journal, 2006
Although the pathogenesis and clinical significance of cerebral white matter lesions remain controversial, it is well established that age and hypertension are the most important factors related to the presence of these lesions.
Cristina Sierra, Antonio Coca
doaj   +2 more sources

Green tea consumption and cerebral white matter lesions in community-dwelling older adults without dementia [PDF]

npj Science of Food
This study investigated the association between green tea or coffee consumption with cerebral white matter lesions and hippocampal and total brain volumes among 8766 community-dwelling participants recruited from the Japan Prospective Studies ...
Shutaro Shibata, Moeko Noguchi-Shinohara, Ayano Shima, Taro Ozaki, Yuta Usui, Yasuyuki Taki, Kazuhiro Uchida, Takanori Honda, Jun Hata, Tomoyuki Ohara, Tatsuya Mikami, Tetsuya Maeda, Masaru Mimura, Kenji Nakashima, Jun-ichi Iga, Minoru Takebayashi, Toshiharu Ninomiya, Kenjiro Ono, On behalf of the Japan Prospective Studies Collaboration for Aging and Dementia (JPSC-AD) study group   +18 more
doaj   +2 more sources

White Matter Lesions in Migraine [PDF]

The American Journal of Pathology, 2021
Migraine, the third most common disease worldwide, is a well-known independent risk factor for subclinical focal deep white matter lesions (WMLs), even in young and otherwise healthy individuals with no cardiovascular risk factors. These WMLs are more commonly seen in migraine patients with transient neurologic symptoms preceding their headaches, the ...
Katharina Eikermann-Haerter, Susie Y. Huang   +1 more
openaire   +2 more sources

Neuroprotection and neuroregeneration: roles for the white matter

Neural Regeneration Research, 2022
Efficient strategies for neuroprotection and repair are still an unmet medical need for neurodegenerative diseases and lesions of the central nervous system.
Vito Antonio Baldassarro, Agnese Stanzani, Luciana Giardino, Laura Calzà, Luca Lorenzini   +4 more
doaj   +1 more source