Results 31 to 40 of about 5,103,599 (293)

Tissue transglutaminase in marmoset experimental multiple sclerosis: discrepancy between white and grey matter. [PDF]

PLoS ONE, 2014
Infiltration of leukocytes is a major pathological event in white matter lesion formation in the brain of multiple sclerosis (MS) patients. In grey matter lesions, less infiltration of these cells occur, but microglial activation is present.
Nathaly Espitia Pinzon, Esther Stroo, Bert A 't Hart, John G J M Bol, Benjamin Drukarch, Jan Bauer, Anne-Marie van Dam   +6 more
doaj   +1 more source

Depression in small-vessel disease relates to white matter ultrastructural damage, not disability. [PDF]

, 2014
OBJECTIVE: To determine whether cerebral small-vessel disease (SVD) is a specific risk factor for depression, whether any association is mediated via white matter damage, and to study the role of depressive symptoms and disability on quality of life (QoL)
Morris, RG, Brookes, RL, Lawrence, AJ, Morris, Robin G., Lawrence, Andrew J.; id_orcid, Herbert, Vanessa, Herbert, V, Brookes, Rebecca L., Markus, Hugh S., Markus, HS   +9 more
core   +1 more source

Evidence for grey matter MTR abnormality in minimally disabled patients with early relapsing-remitting multiple sclerosis [PDF]

, 2004
Objectives: To establish whether magnetisation transfer ratio (MTR) histograms are sensitive to change in normal appearing grey matter (NAGM) in early relapsing-remitting multiple sclerosis (RRMS) in the absence of significant disability; and to assess ...
Griffin, C M B, Kapoor, R., Miller, D.H., Chard, D T, Hadjiprocopis, A., Ramio-Torrenta, L, Barker, G J; id_orcid, Davies, G.R., Ramió-Torrentà, L., Griffin, C.M.B., Rashid, W., Chard, D.T., Davies, G R, Miller, D H, Rashid, W, Thompson, A.J., Kapoor, R, Thompson, A J, Barker, G.J., Hadjiprocopis, A   +19 more
core   +1 more source

Regulation of microglial TMEM119 and P2RY12 immunoreactivity in multiple sclerosis white and grey matter lesions is dependent on their inflammatory environment

Acta Neuropathologica Communications, 2019
Multiple Sclerosis (MS) is the most common cause of acquired neurological disability in young adults, pathologically characterized by leukocyte infiltration of the central nervous system, demyelination of the white and grey matter, and subsequent axonal ...
Thecla A. van Wageningen, Eva Vlaar, Gijs Kooij, Cornelis A. M. Jongenelen, Jeroen J. G. Geurts, Anne-Marie van Dam   +5 more
doaj   +1 more source

Cognitive state following stroke: the predominant role of preexisting white matter lesions.

PLoS ONE, 2014
Background and purposeStroke is a major cause of cognitive impairment and dementia in adults, however the role of the ischemic lesions themselves, on top of other risk factors known in the elderly, remains controversial.
Efrat Kliper, Einor Ben Assayag, Ricardo Tarrasch, Moran Artzi, Amos D Korczyn, Shani Shenhar-Tsarfaty, Orna Aizenstein, Hen Hallevi, Anat Mike, Ludmila Shopin, Natan M Bornstein, Dafna Ben Bashat   +11 more
doaj   +1 more source

White matter damage and cognitive impairment after traumatic brain injury [PDF]

, 2010
White matter disruption is an important determinant of cognitive impairment after brain injury, but conventional neuroimaging underestimates its extent.
Powell, Jane Hilary, Leech, R, K. M. Kinnunen, Counsell, Serena Jane; id_orcid, Bonnelle, V., Bonnelle, V, Sharp, D. J., Kinnunen, K. M., Hawkins, Peter Charlie; id_orcid, Patel, Maneesh Chandrakant, Patel, MC, M. C. Patel, Sharp, David James, Greenwood, Richard, D. J. Sharp, Hawkins, PC, Leech, R., Patel, M. C., Powell, Jane H., Greenwood, R, J. H. Powell, Counsell, S. J., Sharp, DJ, P. C. Hawkins, Counsell, SJ, Powell, JH, R. Greenwood, Kinnunen, KM, R. Leech, Bonnelle, Valerie, Leech, Robert, V. Bonnelle, Kinnunen, Kirsi Maria, Hawkins, R. C., S. J. Counsell   +34 more
core   +1 more source

Cerebral white matter lesions and depressive symptons in elderly adults. [PDF]

, 2000
Background: There is evidence for a vascular cause of late-life depression. Cerebral white matter lesions are thought to represent vascular abnormalities.
Jolles, J., Oudkerk, M., Breteler, M.M., de Groot, J.C, Hofman, A., de Leeuw, F E.   +5 more
core   +4 more sources

Effects of white matter injury on resting state fMRI measures in prematurely born infants. [PDF]

PLoS ONE, 2013
The cerebral white matter is vulnerable to injury in very preterm infants (born prior to 30 weeks gestation), resulting in a spectrum of lesions. These range from severe forms, including cystic periventricular leukomalacia and periventricular hemorrhagic
Christopher D Smyser, Abraham Z Snyder, Joshua S Shimony, Tyler M Blazey, Terrie E Inder, Jeffrey J Neil   +5 more
doaj   +1 more source

Extent of altered white matter in unilateral and bilateral periventricular white matter lesions in children with unilateral cerebral palsy

, 2016
Aims: To investigate the extent of white matter damage in children with unilateral cerebral palsy (UCP) caused by periventricular white matter lesions comparing between unilateral and bilateral lesions; and to investigate a relationship between white ...
Boyd, Roslyn N., Pannek, Kerstin, Rose, S., Fripp, Jurgen, Rose, Stephen E., Pannek, K., Scheck, Simon M., Boyd, Roslyn, Fiori, S., Reid, Lee, Fiori, Simona, Scheck, S., Reid, L., Fripp, J.   +13 more
core   +2 more sources

Added value of double inversion recovery magnetic resonance sequence in detection of cortical and white matter brain lesions in multiple sclerosis

The Egyptian Journal of Radiology and Nuclear Medicine, 2014
Objective: The aim of this study was to evaluate the value of double inversion recovery (DIR) magnetic resonance (MR) sequence in the detection of brain cortical and white matter lesions in multiple sclerosis (MS).
Abdelaziz M. Elnekeidy, May A. Kamal, Amr M. Elfatatry, Mahmoud L. Elskeikh   +3 more
doaj   +1 more source