Results 51 to 60 of about 143,855 (296)

Heterogeneity of multiple sclerosis lesions in fast diffusional kurtosis imaging.

PLoS ONE, 2021
BackgroundMean kurtosis (MK), one of the parameters derived from diffusion kurtosis imaging (DKI), has shown increased sensitivity to tissue microstructure damage in several neurological disorders.MethodsThirty-seven patients with relapsing-remitting MS ...
Christian Thaler, Anna A Kyselyova, Tobias D Faizy, Marie T Nawka, Sune Jespersen, Brian Hansen, Jan-Patrick Stellmann, Christoph Heesen, Klarissa H Stürner, Maria Stark, Jens Fiehler, Maxim Bester, Susanne Gellißen   +12 more
doaj   +1 more source

Confluent Thalamic Hyperintensities in CADASIL [PDF]

, 2010
Background: CADASIL is responsible for diffuse hyperintensities in the white matter on FLAIR images. These lesions are often associated with focal lesions in the basal ganglia such as lacunar infarctions.
Jacqmin, Mathilde, Viswanathan, Anand, Marco During, Jean-Pierre Guichard, Dichgans, Martin, Martin Dichgans, Herve, Dominique, Düring, Marco, Dominique Hervé, Anand Viswanathan, Guichard, Jean-Pierre, Chabriat, Hugues, Mathilde Jacqmin, Hugues Chabriat   +13 more
core   +1 more source

Neuropathology of white matter lesions in vascular cognitive impairment. [PDF]

, 2002
The white matter is an important locus for tissue damage in vascular cognitive impairment and white matter lesions often dominate over gray matter changes.
Englund, Elisabet
core   +3 more sources

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Mechanisms of Cognitive Impairment in Cerebral Small Vessel Disease: Multimodal MRI Results from the St George's Cognition and Neuroimaging in Stroke (SCANS) Study. [PDF]

, 2013
Cerebral small vessel disease (SVD) is a common cause of vascular cognitive impairment. A number of disease features can be assessed on MRI including lacunar infarcts, T2 lesion volume, brain atrophy, and cerebral microbleeds.
Lawrence, AJ, Barrick, Thomas R., Lawrence Andrew J., Barrick Thomas R., Andrew J Lawrence, Robin G Morris, MacKinnon, Andrew D., Hugh S. Markus, Thomas R Barrick, Bhavini Patel, Robin G. Morris, MacKinnon, AD, Bhavini Patel (405150), Barrick, TR, Philip M. Rich (405153), Markus, HS, Andrew D. MacKinnon, Rich, PM, Thomas R. Barrick (405154), Thomas R. Barrick, Hugh S Markus, Lawrence, Andrew J.; id_orcid, Patel, B, Andrew J. Lawrence, MacKinnon Andrew D., Rich, Philip M., Hugh S. Markus (366687), Andrew J. Lawrence (292444), Robin G. Morris (405151), Morris, RG, Patel Bhavini, Morris Robin G., Morris, Robin G., Andrew D MacKinnon, Rich Philip M., Patel, Bhavini, Philip M Rich, Andrew D. MacKinnon (405152), Markus Hugh S., Philip M. Rich, Markus, Hugh S.   +40 more
core   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Quantitative histomorphometry of capillary microstructure in deep white matter

NeuroImage: Clinical, 2019
White matter lesions represent a major risk factor for dementia in elderly people. Magnetic Resonance Imaging (MRI) studies have demonstrated cerebral blood flow reduction in age-related white matter lesions, indicating that vascular alterations are ...
Meghdoot Mozumder, Jose M. Pozo, Santiago Coelho, Marina Costantini, Julie Simpson, J. Robin Highley, Paul G. Ince, Alejandro F. Frangi   +7 more
doaj   +1 more source

Augmentation index is related to white matter lesions [PDF]

Hypertension Research, 2012
The augmentation index (AIx) is a measure of pulse wave reflection from peripheral muscular conduit arteries, and is assumed to increase with stiffened arteries. A white matter lesion (WML) is generally regarded as a chronic ischemic lesion, which is associated with cerebral small-vessel arteriosclerosis.
Takahiro, Nakano, Akira, Munakata, Norihito, Shimaura, Kenichiroh, Asano, Hiroki, Ohkuma   +4 more
openaire   +2 more sources

Astrocyte heterogeneity in brain metastases

Molecular Oncology, EarlyView.
Astrocytes emerge as pivotal regulators of metastatic colonization, survival, immune remodeling, and therapy response associated with an increasing heterogeneity that requires spatially and longitudinally resolved approaches to uncover regulatory programs and guide context‐specific therapies.
Carolina Hernández‐Oliver, Neibla Priego, Manuel Valiente   +2 more
wiley   +1 more source