Results 61 to 70 of about 5,007,319 (296)

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Artificial molecular machines and motors—Design and control of nanoscale motion

FEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

Gray-white matter ratio in pediatric and adult cardiopulmonary arrest studies: a rapid review

Resuscitation Plus
Objectives: The gray-white matter ratio is used to estimate tissue edema on head computed tomography scans in cardiac arrest research. This rapid review aimed to determine whether gray-white matter ratio values differed between studies that included ...
Kie Honjo, Geraldine Goco, Ahmed Al Khalifah, Nicole McKinnon, Barnaby R. Scholefield, Suzanne Laughlin, Anne-Marie Guerguerian   +6 more
doaj   +1 more source

Restricted Diffusion in Vanishing White Matter

, 2012
To investigate the occurrence of restricted diffusion in vanishing white matter, the affected structures,the time of occurrence in the disease course, and the histopathologic correlate. Retrospective observational study. Forty-six patients with vanishing
Steenweg, M.E., van der Knaap, M.S., van der Lei, Hannemieke D. W., van der Lei, H.D.W., van Wieringen, Wessel N., Bugiani, M., Barkhof, F., Pouwels, Petra J. W., van der Knaap, Marjo S., Vent, Inge M., van Wieringen, W.N., Pouwels, P.J.W., Vent, I.M., Bugiani, Marianna, Steenweg, Marjan E., Barkhof, Frederik, van Wieringen, W.N.; id_orcid   +16 more
core   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Nonparenchymal fluid is the source of increased mean diffusivity in preclinical Alzheimer's disease

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, 2019
Introduction Although increased mean diffusivity of the white matter has been repeatedly linked to Alzheimer's disease pathology, the underlying mechanism is not known.
Farshid Sepehrband, Ryan P. Cabeen, Giuseppe Barisano, Nasim Sheikh‐Bahaei, Jeiran Choupan, Meng Law, Arthur W. Toga, Alzheimer's Disease Neuroimaging Initiative   +7 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Compression analysis of the gray and white matter of the spinal cord

Neural Regeneration Research, 2020
The spinal cord is composed of gray matter and white matter. It is well known that the properties of these two tissues differ considerably. Spinal diseases often present with symptoms that are caused by spinal cord compression.
Norihiro Nishida, Fei Jiang, Junji Ohgi, Akihiro Tanaka, Yasuaki Imajo, Hidenori Suzuki, Masahiro Funaba, Takashi Sakai, Itsuo Sakuramoto, Xian Chen   +9 more
doaj   +1 more source

Late onset vanishing white matter disease presenting with learning difficulties

, 2012
Background: Vanishing white matter is an inherited leukoencephalopathy with typical childhood onset. Late onset forms are rare and may present with an extended range of phenotypes.
van der Knaap, M.S., van der Lei, Hannemieke D. W., Ernestina Santos, van der Lei, H.D.W., Santos, Ernestina, Damásio, Joana, van der Knaap, Marjo S., Hannemieke D.W. van der Lei, Marjo S. van der Knaap, Santos, E., Joana Damásio, Damasio, J., Lei, H.D.W. van der, Knaap, M.S. van der   +13 more
core   +1 more source