Results 41 to 50 of about 5,007,319 (296)

The effect of N-acetyl-aspartyl-glutamate and N-acetyl-aspartate on white matter oligodendrocytes [PDF]

, 2009
Elevations of the levels of N-acetyl-aspartyl-glutamate (NAAG) and N-acetyl-aspartate (NAA) are associated with myelin loss in the leucodystrophies Canavan's disease and Pelizaeus-Merzbacher-like disease. NAAG and NAA can activate and antagonize neuronal
Attwell, D., Koodziejczyk, Karolina, Kolodziejczyk, K., Wade, A., Kradttir, Ragnhildur, Wade, Anna, Karadottir, R., Hamilton, Nicola B.; id_orcid, Attwell, David, Hamilton, N. B.   +9 more
core   +1 more source

Experience With Performing Rheocarna Therapy via the Single‐Needle Method for Treatment of Chronic Limb‐Threatening Ischemia

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction This study investigated the safety and efficacy of single‐needle Rheocarna therapy for chronic limb‐threatening ischemia (CLTI) with wounds. Methods Six patients with CLTI involving ulcers unresponsive to revascularization underwent single‐needle Rheocarna treatment.
Yasutaka Yamauchi, Rie Tanaka, Reona Kawahira, Shingo Nabeta, Kouhei Naoi, Kazuhito Kitajima, Akira Wada, Tomonari Takagi, Norihiko Ohura, Akira Miyamoto   +9 more
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Neuroprotection and neuroregeneration: roles for the white matter

Neural Regeneration Research, 2022
Efficient strategies for neuroprotection and repair are still an unmet medical need for neurodegenerative diseases and lesions of the central nervous system.
Vito Antonio Baldassarro, Agnese Stanzani, Luciana Giardino, Laura Calzà, Luca Lorenzini   +4 more
doaj   +1 more source

Bayesian model selection for pathological neuroimaging data applied to white matter lesion segmentation. [PDF]

, 2015
In neuroimaging studies, pathologies can present themselves as abnormal intensity patterns. Thus, solutions for detecting abnormal intensities are currently under investigation.
Willem H. Bouvy, Sudre, Carole H., Bouvy, W, Josephine Barnes, Biessels, G, Biessels, Geert Jan, Barnes, Josephine, Sudre, C, Ourselin, Sebastien, Bouvy, Willem H., Sebastien Ourselin, Cardoso, MJ, Ourselin, S, M. Jorge Cardoso, Geert Jan Biessels, Cardoso, M. Jorge, Barnes, J, Sudre, Carole H.; id_orcid, Cardoso, M. Jorge; id_orcid, Carole H. Sudre   +19 more
core   +2 more sources

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Defective glial maturation in vanishing white matter disease.

, 2011
Vanishing white matter (VWM) disease is a genetic leukoencephalopathy linked to mutations in the eukaryotic translation initiation factor 2B. It is a disease of infants, children, and adults who experience a slowly progressive neurologic deterioration ...
Polder, E., Scheper, G.C., Boor, Ilja, Martha S. Windrem, Polder, Emiel, Marianna Bugiani, van Kesteren, Ronald E., Goldman, Steven A., Ilja Boor, van der Knaap, Marjo S., Postma, N.L., Windrem, M.S., Van Kesteren, R.E., Marjo S. van der Knaap, Hol, Elly M., Van Kollenburg, B., Scheper, Gert C., Windrem, Martha S., Hol, E.M., Van Berkel, C., Elly M. Hol, Bugiani, M., Emiel Polder, Ronald E. van Kesteren, van Kesteren, R.E.; id_orcid, Postma, Nienke, Gert C. Scheper, Carola van Berkel, Postma, N., Boor, I., van Kollenburg, Barbara, Van der Knaap, M.S., Nienke Postma, van Berkel, Carola, Barbara van Kollenburg, Bugiani, Marianna, van Kollenburg, B.C.A.E., Goldman, S.A., Steven A. Goldman   +38 more
core   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

The Robustness of White Matter Brain Networks Decreases with Aging

Journal of Integrative Neuroscience
Background: White matter (WM) is a principal component of the human brain, forming the structural basis for neural transmission between cortico-cortical and subcortical structures.
Chenye Huang, Xie Wang, Daojun Xie
doaj   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source