Results 221 to 230 of about 5,103,599 (293)

Relationship between elevated homocysteine levels and the degree of white matter lesions in stroke patients. [PDF]

Medicine (Baltimore)
Wu X, Du Y, Wei N, Pan L, Cao C.
europepmc   +1 more source

Polydopamine Nanoparticle‐Mediated Precise Near‐Infrared Optical Stimulation for Cognitive Enhancement

Advanced Science, EarlyView.
Polydopamine nanoparticles enable a precise, non‐genetic, and transcranial neuromodulation strategy via near‐infrared photothermal stimulation. By activating TRPV1 channels, this approach specifically enhances hippocampal gamma oscillations, thereby rescuing spatial memory deficits in models of perioperative neurocognitive disorder.
Yan‐Bo Zhou, Qiong Xue, Su‐Xuan Hou, Ke‐Yao Zhang, Wei‐Tong Pan, Ting‐Ting Zeng, Yu‐Ge Wang, Daqing Ma, Chenguang Zhao, Pan‐Miao Liu, Jian‐Jun Yang   +10 more
wiley   +1 more source

The Dual Role of A2aR in Neuroinflammation: Modulating Microglial Polarization in White Matter Lesions. [PDF]

eNeuro
Cheng C, Cheng W, Wang Y, Chen X, Zhang L, Li Y, Shen F, Yuan D, Hong P, Huang W.   +9 more
europepmc   +1 more source

Disrupting Helicobacter pylori Iron Homeostasis With Bismuth Nanodrug‐Mediated Nutritional Trap for Targeted Gastric Infection Therapy

Advanced Science, EarlyView.
A “nutritional trap” strategy centered on disrupting bacterial iron homeostasis is proposed. The synthesized Bi‐TP@FU (TBF) can target Helicobacter pylori, interfere with the bacterial iron uptake and utilization processes to disrupt its iron homeostasis, induce bacterial death, and meanwhile preserve the balance of the intestinal flora.
Tianye Fang, Jinzhe Tong, Feng Feng, Cong Liu, Chang Shu, Jiaying Zhu, Shibo Zhang, Shuyue Deng, Wanchao Zuo, Yuhan Song, Jun Yang, Yanmin Ju, Yingying Xing, Jianjun Dai   +13 more
wiley   +1 more source

Impact of white matter lesions on associations between prehospital blood pressure and outcomes in spontaneous intracerebral hemorrhage. [PDF]

Eur Stroke J
Larsen KT, Holt Jahr S, Nordahl Selseth M, Lied-Herland T, Hillestad V, Ihle-Hansen H, Sandset EC, Rønning OM, Kristoffersen ES.   +8 more
europepmc   +1 more source

Rewiring Pyroptosis to Potentiate Cancer Immunotherapy via a Gasdermin D Agonist Bypassing Caspase‐3

Advanced Science, EarlyView.
This work introduces a small‐molecule agonist, DIBDO, that bypasses Casp‐3 to directly trigger GSDMD‐mediated pyroptosis in tumors. Activated by glutathione, DIBDO generates singlet oxygen and molecular iodine, blocking Casp‐3 pathways and inducing immunogenic cell death.
Dan Zhao, Lingling Zhang, Yue Wen, Lianghui Cheng, Sidan Tian, Fanling Meng, Liang Luo   +6 more
wiley   +1 more source

The impact of white matter lesions on seizure recurrence after first epileptic seizures in the elderly: a prospective study. [PDF]

Neurol Res Pract
Weil J, Linka L, Gurschi M, Kidik SA, Fuchs A, Schoenfeldt R, Zahnert F, Möller L, Menzler K, Kemmling A, Knake S, Habermehl L.   +11 more
europepmc   +1 more source

Molecular Dynamics‐Guided Sterol Engineering of mRNA‐Lipid Nanoparticles Reprograms Biodistribution and Enhances Spleen‐Selective Immunity

Advanced Science, EarlyView.
Sterol engineering enables precise control of mRNA lipid nanoparticles by tuning membrane organization. Replacing cholesterol with bile acid‐derived sterols redirects protein expression from the liver to the spleen. Notably, CA‐20 LNP enhances antigen‐specific immune responses while exhibiting a favorable safety profile, highlighting sterols as a ...
Sanghyuk Jeon, Seo‐Hyeon Bae, Jungyong Ji, Jisun Lee, Hosam Choi, Min‐Ho Kang, Sang‐In Park, Hyemin Kim, Nakyung Lee, Hajin Lee, Seonghoon Kim, Jungmin Kim, Subin Yoon, Seonghyun Lee, Seongje Cho, Dahyeon Ha, Ayoung Oh, Sohee Jo, Huijeong Choi, Yeeun Lee, Sowon Lee, Hyo‐Jung Park, Gitak Nam, Jisu Shin, Yujin Kang, Wonpil Im, Kiyoun Lee, Jae‐Hwan Nam   +27 more
wiley   +1 more source

Correction: The impact of white matter lesions on seizure recurrence after first epileptic seizures in the elderly: a prospective study. [PDF]

Neurol Res Pract
Weil J, Linka L, Gurschi M, Kidik SA, Fuchs A, Schoenfeldt R, Zahnert F, Möller L, Menzler K, Kemmling A, Knake S, Habermehl L.   +11 more
europepmc   +1 more source