Results 51 to 60 of about 2,657,308 (290)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Impact of Trichoderma-based products on Sclerotinia sclerotiorum

Pesquisa Agropecuária Tropical
Trichoderma-based products are deployed on a large scale in regions where white mold is important. However, little is known about the contribution of alternating these products on sclerotia parasitism, disease incidence and
Rafael Coelho Silva, Rafaela Araújo Guimarães, Luiz Miguel Oliveira Costa, Flávio Henrique Vasconcelos de Medeiros   +3 more
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

A comparative study on the use of white light, black light 365 nm and 395 nm for screening mold on food surfaces [PDF]

Songklanakarin Journal of Science and Technology (SJST)
Mold contamination on food presents significant threats to food safety and public health, necessitating the detection and prevention of mold presence in food products to ensure their quality and safety. The study investigates the effectiveness of white
Aryn Kraiwattanapong, Athip Kraiwattanapong, Nitipan Promprasoeth, Orawin Luecha   +3 more
doaj  

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Gene Expression Profiling Soybean Stem Tissue Early Response to Sclerotinia sclerotiorum and In Silico Mapping in Relation to Resistance Markers

The Plant Genome, 2009
White mold, caused by (Lib.) de Bary, can be a serious disease of crops grown under cool, moist environments. In many plants, such as soybean [ (L.) Merr.], complete genetic resistance does not exist.
Bernarda Calla, Tri Vuong, Osman Radwan, Glen L. Hartman, Steven J. Clough   +4 more
doaj   +1 more source

Chemical composition and in vitro inhibitory effects of essential oils from fruit peel of three Citrus species and limonene on mycelial growth of Sclerotinia sclerotiorum [PDF]

Brazilian Journal of Biology, 2019
Essential oils (EO) from aromatic and medicinal plants generally perform a diverse range of biological activities because they have several active constituents that work in different mechanisms of action.
A. L. B. Dias, W. C. Sousa, H. R. F. Batista, C. C. F. Alves, E. L. Souchie, F. G. Silva, P. S. Pereira, E. M. Sperandio, C. M. Cazal, M. R. Forim, M. L. D. Miranda   +10 more
doaj   +1 more source

Control of white mold in bean plants by homeopathic medicines [PDF]

African Journal of Agricultural Research, 2016
Common bean (Phaseolus vulgaris) is one of the main Brazilian agricultural crop. It is affected by numerous diseases during its life cycle; one of these includes the white mold caused by the fungus Sclerotinia sclerotiorum. The objective of this study was to verify the control of white mold in bean plants by homeopathic medicines.
Broti Rissato Bruna, Renato Stangarlin Jos eacute, Coltro Roncato Sidiane, Dangelo Forlin Dildey Omari, Della Valentina Gon ccedil alves Edilaine, Broetto Laline, Jos eacute Kuhn Odair, Lorenzetti Eloisa, Muriel Mioranza Thaisa, Peli ccedil on Pereira Figueira Eliana, Fernanda Barrientos Webler Tulya, Cristina Urbanski Laureth J eacute ssica   +11 more
openaire   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source