The age incidence of any cancer can be explained by a one-mutation model [PDF]
arXiv, 2008 We propose a one mutation model for cancer with a mutation rate that increases with time. Under rather general hypotheses the number of mutations is necessarily a (non homogeneous) Poisson process with the prescribed mutation rate. We show that the cumulative probability of cancer up to time $t$ is, up to a multiplicative constant, an antiderivative of
arxiv
Cutaneous white spots in a child with polycystic kidneys: a clue to TSC2/PKD1 gene mutation [PDF]
, 2000 Markus Sperandio +5 more
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Advanced Functional Materials, EarlyView.Oct4‐nanoscript, a biomimetic nanoparticle‐based artificial transcription factor, precisely regulates cellular rejuvenation by activating Oct4 target genes, restoring epigenetic marks, and reducing DNA damage. In a progeria model, it effectively rescued aging‐associated pathologies and extended lifespan.
Hongwon Kim +8 more
wiley +1 more source
Interference effects of deleterious and beneficial mutations in large asexual populations [PDF]
Genetics 211, 1357-1369 (2019), 2018 Linked beneficial and deleterious mutations are known to decrease the fixation probability of a favorable mutation in large asexual populations. While the hindering effect of strongly deleterious mutations on adaptive evolution has been well studied, how weak deleterious mutations, either in isolation or with superior beneficial mutations, influence ...
arxiv
The Arabidopsis immutans Mutation Affects Plastid Differentiation and the Morphogenesis of White and Green Sectors in Variegated Plants [PDF]
, 2001 Maneesha Aluru +3 more
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Advanced Healthcare Materials, EarlyView.Deinococcus radiodurans‐derived extracellular vesicles (R1‐EVs) provide radioprotection against total‐body irradiation‐induced acute radiation syndrome in mice. R1‐EVs mitigate oxidative damage by scavenging free radicals, promoting intestinal repair, enhancing hematopoietic function, and modulating immune responses. This study highlights the potential
Jeong Moo Han +7 more
wiley +1 more source
Modelling the order of driver mutations and metabolic mutations as structures in cancer dynamics [PDF]
arXiv, 2017 Recent works have stressed the important role that random mutations have in the development of cancer phenotype. We challenge this current view by means of bioinformatic data analysis and computational modelling approaches. Not all the mutations are equally important for the development of metastasis.
arxiv
Chickens First\ud \ud Speciation by “Hopeful Monsters” in Fraternal Supertwins\ud [PDF]
, 2008 The idea of “hopeful monster” was proposed by Goldschmidt who envisioned that speciation could occur instantaneously via major chromosomal rearrangement in a one-step process; but he could not unravel how similar individual in the opposite sex to appear ...
Zhang, Dr. Jianyi
core
Ectopic White Matter Neurons, a Developmental Abnormality That May Be Caused by thePSEN1S169L Mutation in a Case of Familial AD with Myoclonus and Seizures [PDF]
, 2001 Masaki Takao +11 more
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An eleven-year history of Vanishing White Matter Disease in an adult patient with no cognitive decline and EIF2B5 mutations. A case report [PDF]
, 2021 Lucia Trevisan +9 more
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