Results 111 to 120 of about 731,846 (342)

Jeux de trompe-l’œil dans une cité déchue : La Nouvelle-Orléans de George Washington Cable dans Old Creole Days

E-REA, 2016
Throughout his work, 19th century writer George Washington Cable, who was born in New Orleans, kept describing his native city with a tender and yet ruthless eye, before being almost forced into exile for having sharply turned his pen to a critique of ...
Valérie CROISILLE
doaj   +1 more source

Frequency and characteristics of the V617F mutation in 23 cerebral venous sinus thrombosis patients with thrombocytosis

Journal of International Medical Research, 2020
Objective To analyse the frequency and characteristics of the Janus kinase 2 ( JAK2) V617F mutation in patients with cerebral venous sinus thrombosis (CVST) with thrombocytosis.
Qiang Ma
doaj   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Methylenetetrahydrofolate reductase homozygous mutation in a young boy with cerebellar infarction

Pediatric Reports, 2009
Posterior circulation vascular occlusive disease in children is a rare and uncommonly reported event. Among the numerous risk factors, the methylenetetrahydrofolate reductase (MTHFR) mutation is considered to be a common genetic cause of thrombosis in ...
Alberto Spalice, Francesca Del Balzo, Francesco Massimo Perla, Enrico Properzi, Carla Carducci, Italo Antonozzi, Paola Iannetti   +6 more
doaj   +1 more source

MAP1B mutations cause intellectual disability and extensive white matter deficit [PDF]

, 2018
G. Bragi Walters, Ómar Gústafsson, Garðar Sveinbjörnsson, Valgerdur Kristin Eiriksdottir, Arna B. Agustsdottir, Guðrún A. Jónsdóttir, Stacy Steinberg, Arni F. Gunnarsson, Magnus I. Magnusson, Unnur Unnsteinsdóttir, Amy L. Lee, Aðalbjörg Jónasdóttir, Ásgeir Sigurðsson, Áslaug Jónasdóttir, Ástrós Skúladóttir, Lina Jönsson, Muhammad Sulaman Nawaz, Patrick Sulem, Mike Frigge, Andrés Ingason, Áskell Löve, Gudmundur L. Norddhal, Mark Zervas, Daníel F. Guðbjartsson, Magnús Ö. Úlfarsson, Evald Sæmundsen, Hreinn Stefánsson, Kāri Stefánsson   +27 more
openalex   +1 more source

D-Score: A White-Box Diagnosis Score for CNNs Based on Mutation Operators [PDF]

, 2023
Xin Zhang, Yuqi Song, Xiaofeng Wang, Fei Zuo   +3 more
openalex   +1 more source

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source

Premature polyadenylation-mediated loss of stathmin-2 is a hallmark of TDP-43-dependent neurodegeneration. [PDF]

, 2019
Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are associated with loss of nuclear transactive response DNA-binding protein 43 (TDP-43).
Artates, Jon W, Baughn, Michael W, Beccari, Melinda S, Bennett, C Frank, Cleveland, Don W, Da Cruz, Sandrine, Drenner, Kevin, Freyermuth, Fernande, Lagier-Tourenne, Clotilde, Lin, Nianwei, López-Erauskin, Jone, McMahon, Moira A, Melamed, Ze'ev, Ohkubo, Takuya, Ravits, John, Rigo, Frank, Rodriguez, Maria, Sun, Ying, Wu, Dongmei, Zhang, Ouyang   +19 more
core  

Identification of a novel nonsense mutation on the Pax3 gene in ENU-derived white belly spotting mice and its genetic interaction with c-Kit [PDF]

, 2010
Xiao-Li Guo, Hai‐Bin Ruan, Yan Li, Xiang Gao, Wei Li   +4 more
openalex   +1 more source

Naked cuticle is essential for Drosophila wing development beyond Wingless signaling

FEBS Open Bio, EarlyView.
Naked cuticle (Nkd), a Wnt signaling inhibitor, assumes extensive roles in Drosophila wing development. Overexpressing Nkd causes smaller, crumpled wings, while also perturbing multiple signaling pathways and developmental genes. A specific region (R1S) is critical for Nkd's function as a signaling integrator, offering new insights for studying its ...
Rui Wang, Ping Wang
wiley   +1 more source