Results 111 to 120 of about 3,299,410 (331)
Advanced Functional Materials, EarlyView.Oct4‐nanoscript, a biomimetic nanoparticle‐based artificial transcription factor, precisely regulates cellular rejuvenation by activating Oct4 target genes, restoring epigenetic marks, and reducing DNA damage. In a progeria model, it effectively rescued aging‐associated pathologies and extended lifespan.
Hongwon Kim +8 more
wiley +1 more source
LETHALITY PATTERNS AND MORPHOLOGY OF SELECTED LETHAL AND SEMI-LETHAL MUTATIONS IN THE ZESTE-WHITE REGION OF DROSOPHILA MELANOGASTER [PDF]
, 1972 M P Shannon +3 more
openalex +1 more source
Advanced Functional Materials, EarlyView.This work utilizes poly(heptazine imides) as a model system to demonstrate how fine‐tuning the crystal structure influences the photocatalytic properties of layered carbon nitrides in the hydrogen evolution reaction. In particular, the nature of rotational defects and the hydration shell of cations are key contributors to enhanced hydrogen evolution ...
Diana V. Piankova +11 more
wiley +1 more source
Novel Alanyl-tRNA Synthetase 2 Pathogenic Variants in Leukodystrophies
Frontiers in Neurology, 2019 The white matter disease spectrum is associated with many genetic diseases, including AARS2, CADASIL, ALD, and others. In this study, to determine the novel alanyl-tRNA synthetase 2 mutation implicated in white matter disease, several families with an ...
Xingao Wang +21 more
doaj +1 more source
Nanobody‐Decorated Lipid Nanoparticles for Enhanced mRNA Delivery to Tumors In Vivo
Advanced Healthcare Materials, EarlyView.This study presents a targeted mRNA‐LNP platform engineered with anti‐PSMA nanobodies for prostate cancer therapy. Using different in vivo models, the authors demonstrate selective uptake and mRNA delivery in PSMA+ cancer cells. However, while targeting is enhanced, mRNA delivery efficacy is limited by tissue penetration, tumor necrosis, and immune ...
Pol Escudé Martinez de Castilla +16 more
wiley +1 more source
Methylenetetrahydrofolate reductase homozygous mutation in a young boy with cerebellar infarction
Pediatric Reports, 2009 Posterior circulation vascular occlusive disease in children is a rare and uncommonly reported event. Among the numerous risk factors, the methylenetetrahydrofolate reductase (MTHFR) mutation is considered to be a common genetic cause of thrombosis in ...
Alberto Spalice +6 more
doaj +1 more source
Mutation of the RIIβ Subunit of Protein Kinase A Differentially Affects Lipolysis but Not Gene Induction in White Adipose Tissue [PDF]
, 1999 Josep V. Planas +3 more
openalex +1 more source
Advanced Healthcare Materials, EarlyView.An ex vivo glomerular filtration barrier is engineered using electrospun, biomimetic membranes seeded with human glomerular cells. The model supports fenestrated endothelium and podocyte foot processes under flow, mimics size‐selective filtration, and enables disease modeling with hiPSC‐derived podocytes, offering a powerful platform for studying ...
Camilla Mussoni +8 more
wiley +1 more source
Ancestral Protein‐Based Lighting
Advanced Materials, EarlyView.The ancestral sequence reconstruction (ASR) method applied to a large dataset of modern fluorescent proteins (FPs) led to a bright ancestral‐like FP suitable for photon down‐conversion in bio‐hybrid light‐emitting diodes (Bio‐HLEDs). Abstract Protein‐optoelectronics is a paradigm toward eco‐designed and sustainable technologies.
Stephanie Willeit +7 more
wiley +1 more source
Incidence of the endothelin receptor B mutation that causes lethal white foal syndrome in white-patterned horses [PDF]
, 2001 Elizabeth M. Santschi +3 more
openalex +1 more source