Results 111 to 120 of about 3,646,381 (383)
Microstructural white matter damage on MRI is associated with disease severity in Dutch-type cerebral amyloid angiopathy [PDF]
Peak width of skeletonized mean diffusivity (PSMD) is an emerging diffusion-MRI based marker to study subtle early alterations to white matter microstructure.
Biessels, Geert Jan +17 more
core +1 more source
Presymptomatic spinal cord pathology in c9orf72 mutation carriers: A longitudinal neuroimaging study
Annals of Neurology, 2019 C9orf72 hexanucleotide repeats expansions account for almost half of familial amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) cases.
G. Querin +14 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.Patient‐derived xenografts (PDXs) can be improved by implantation of a humanized niche. We tested different biomaterials and approaches, and demonstrate that the combination of an injectable biomaterial for scaffold creation plus an intravenous route for acute myeloid leukemia (AML) xenotransplantation provide the most convenient and robust approach to
Daniel Busa +13 more
wiley +1 more source
MR Elastography Analysis of Glioma Stiffness and IDH1-Mutation Status
American Journal of Neuroradiology, 2018 Tumor stiffness properties were prospectively quantified in 18 patients with histologically proved gliomas using MR elastography. Images were acquired on a 3T MR imaging unit with a vibration frequency of 60 Hz.
K. Pepin +8 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.Triacsin C inhibition of the acyl‐CoA synthetase long chain (ACSL) family decreases multiple myeloma cell survival, proliferation, mitochondrial respiration, and membrane potential. Made with Biorender.com. Multiple myeloma (MM) is an incurable cancer of plasma cells with a 5‐year survival rate of 59%.
Connor S. Murphy +12 more
wiley +1 more source
Learning How to Mutate Source Code from Bug-Fixes [PDF]
arXiv, 2018 Mutation testing has been widely accepted as an approach to guide test case generation or to assess the effectiveness of test suites. Empirical studies have shown that mutants are representative of real faults; yet they also indicated a clear need for better, possibly customized, mutation operators and strategies.
arxiv
Plasmid-based lacZalpha assay for DNA polymerase fidelity: application to archaeal family-B DNA polymerase [PDF]
, 2009 The preparation of a gapped pUC18 derivative, containing the lacZalpha reporter gene in the single-stranded region, is described. Gapping is achieved by flanking the lacZalpha gene with sites for two related nicking endonucleases, enabling the excision ...
Bebenek +28 more
core +2 more sources
White grapes arose through the mutation of two similar and adjacent regulatory genes.
The Plant Journal, 2007 Most of the thousands of grapevine cultivars (Vitis vinifera L.) can be divided into two groups, red and white, based on the presence or absence of anthocyanin in the berry skin, which has been found from genetic experiments to be controlled by a single ...
A. R. Walker +5 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.Prostate cancer is a leading malignancy with significant clinical heterogeneity in men. An 11‐gene signature derived from dysregulated epithelial cell markers effectively predicted biochemical recurrence‐free survival in patients who underwent radical surgery or radiotherapy.
Zhuofan Mou, Lorna W. Harries
wiley +1 more source
Astrocytes are central in the pathomechanisms of vanishing white matter.
Journal of Clinical Investigation, 2016 Vanishing white matter (VWM) is a fatal leukodystrophy that is caused by mutations in genes encoding subunits of eukaryotic translation initiation factor 2B (eIF2B). Disease onset and severity are codetermined by genotype.
S. Dooves +18 more
semanticscholar +1 more source