Results 121 to 130 of about 3,646,381 (383)
Clinical significance of stratifying prostate cancer patients through specific circulating genes
Molecular Oncology, EarlyView.We tested a specific panel of genes representative of luminal, neuroendocrine and stem‐like cells in the blood of prostate cancer patients, showing predictive value from diagnosis to late stages of disease. This approach allows monitoring of treatment responses and outcomes at specific time points in trajectories.
Seta Derderian +12 more
wiley +1 more source
Identification of novel therapeutic targets in the PI3K/AKT/mTOR pathway in hepatocellular carcinoma using targeted next generation sequencing. [PDF]
, 2014 Understanding genetic aberrations in cancer leads to discovery of new targets for cancer therapies. The genomic landscape of hepatocellular carcinoma (HCC) has not been fully described. Therefore, patients with refractory advanced/metastatic HCC referred
Janku, Filip +4 more
core +3 more sources
Adult-onset vanishing white matter disease due to a novel EIF2B3 mutation.
Archives of Neurology, 2012 OBJECTIVE To report a novel mutation in the gene EIF2B3 responsible for a late-onset form of vanishing white matter disease. DESIGN Case report. SETTING University teaching hospital.
R. La Piana +6 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.The complex mode of action of the topoisomerase II inhibitor etoposide in triggering apoptosis involves several mechanisms: overexpression of the mitochondrial protein VDAC1, leading to its oligomerization and formation of a large channel that mediates the release of pro‐apoptotic protein; and overexpression of the apoptosis regulators p53, Bax, and ...
Aditya Karunanithi Nivedita +1 more
wiley +1 more source
Tilting modules arising from knot invariants [PDF]
arXiv, 2020 We construct tilting modules over Jacobian algebras arising from knots. To a two-bridge knot $L[a_1,\ldots,a_n]$, we associate a quiver $Q$ with potential and its Jacobian algebra $A$. We construct a family of canonical indecomposable $A$-modules $M(i)$, each supported on a different specific subquiver $Q(i)$ of $Q$.
arxiv
A plasmid-based lacZα gene assay for DNA polymerase fidelity measurement [PDF]
, 2013 A significantly improved DNA polymerase fidelity assay, based on a gapped plasmid containing the lacZα reporter gene in a single-stranded region, is described.
Connolly, Bernard A +2 more
core +1 more source
Blood, 2014 Patients with essential thrombocythemia may carry JAK2 (V617F), an MPL substitution, or a calreticulin gene (CALR) mutation. We studied biologic and clinical features of essential thrombocythemia according to JAK2 or CALR mutation status and in relation ...
E. Rumi +19 more
semanticscholar +1 more source
Molecular and functional profiling unravels targetable vulnerabilities in colorectal cancer
Molecular Oncology, EarlyView.We used whole exome and RNA‐sequencing to profile divergent genomic and transcriptomic landscapes of microsatellite stable (MSS) and microsatellite instable (MSI) colorectal cancer. Alterations were classified using a computational score for integrative cancer variant annotation and prioritization.
Efstathios‐Iason Vlachavas +15 more
wiley +1 more source
White matter diffusion alterations precede symptom onset in autosomal dominant Alzheimer\u27s disease [PDF]
, 2018 White matter alterations are present in the majority of patients with Alzheimer\u27s disease type dementia. However, the spatiotemporal pattern of white matter changes preceding dementia symptoms in Alzheimer\u27s disease remains unclear, largely due to ...
Araque Caballero, Miguel Ángel +7 more
core +1 more source
Annals of Clinical and Translational Neurology, 2018 We aimed to investigate mutation‐specific white matter (WM) integrity changes in presymptomatic and symptomatic mutation carriers of the C9orf72, MAPT, and GRN mutations by use of diffusion‐weighted imaging within the Genetic Frontotemporal dementia ...
L. Jiskoot +29 more
semanticscholar +1 more source