Results 131 to 140 of about 718,264 (305)

Viral‐Mediated Connexin 26 Expression Combined with Dexamethasone Rescues Hearing in a Conditional Gjb2 Null Mice Model

Advanced Science, EarlyView.
AAV2.7m8 serotype combined with the gfaABC1D promoter targets infection of supporting cells (SCs). AAV2.7m8‐gfaABC1D‐Gjb2 administration to mice results in excessive immune responses. The combination of AAV2.7m8‐gfaABC1D‐Gjb2 with dexamethasone (DEX) shows a synergistic effect and enhances the gene therapy effect in a conditional Cx26 null mice model ...
Xiaohui Wang, Li Zhang, Sen Chen, Le Xie, Yue Qiu, Chenyang Kong, Ge Yin, Weijia Kong, Yu Sun   +8 more
wiley   +1 more source

Familial tumoral calcinosis and testicular microlithiasis associated with a new mutation of GALNT3 in a white family [PDF]

, 2006
Maria Francesca Campagnoli, Angela Pucci, Emanuela Garelli, Adriana Carando, Claudio Defilippi, R. Lala, G. Ingrosso, Irma Dianzani, Marco Forni, Ugo Ramenghi   +9 more
openalex   +1 more source

Wolff–Parkinson–White syndrome: De novo variants and evidence for mutational burden in genes associated with atrial fibrillation [PDF]

, 2020
Zeynep Coban‐Akdemir, Wu‐Lin Charng, Mahshid S. Azamian, Ingrid S. Paine, Jaya Punetha, Christopher M. Grochowski, Tomasz Gambin, Santiago O. Valdés, Bryan C. Cannon, Gladys Zapata, Patricia Hernandez, Shalini N. Jhangiani, HarshaVardhan Doddapaneni, Jianhong Hu, Fatima Boricha, Donna M. Muzny, Eric Boerwinkle, Yaping Yang, Richard A. Gibbs, Jennifer E. Posey, Xander H.T. Wehrens, John W. Belmont, Jeffrey J. Kim, Christina Y. Miyake, James R. Lupski, Seema R. Lalani   +25 more
openalex   +1 more source

AAVR Expression is Essential for AAV Vector Transduction in Sensory Hair Cells

Advanced Science, EarlyView.
Decreased sensitivity to AAV vector transduction in the outer hair cells (OHCs) of adult mice is primarily attributed to reduction of AAVR (Kiaa0319l; Au040320). Knockout of AAVR reduces AAV vector transduction efficiency in both inner hair cells (IHCs) and OHCs in neonatal mice.
Fan Wu, Guisheng Chen, Rui Hu, Peiwen Liu, Jintao Lou, Wenji Zhao, Zuhong He, Suhua Sha, Yiqing Zheng   +8 more
wiley   +1 more source

A Determination of the Magnitude of the Cell “Sensitive Volume” Associated with the White-Eye Mutation in X-Rayed Drosophila—

, 1936
Caryl P. Haskins, E. V. Enzmann
openalex   +1 more source

C3H/HeJ mice carrying a toll-like receptor 4 mutation are protected against the development of insulin resistance in white adipose tissue in response to a high-fat diet [PDF]

, 2007
Marjorie Poggi, Delphine Bastelica, Philippe Gual, Miguel A. Iglesias, Thierry Grémeaux, Claude Knauf, Franck Peiretti, Monique Verdier, I. Juhan‐Vague, Jean‐François Tanti, Rémy Burcelin, Marie‐Christine Alessi   +11 more
openalex   +1 more source

Functional Analysis of KIT Gene Structural Mutations Causing the Porcine Dominant White Phenotype Using Genome Edited Mouse Models [PDF]

, 2020
Guanjie Sun, Xinyu Liang, Ke Qin, Yufeng Qin, Xuan Shi, Peiqing Cong, Delin Mo, Xiaohong Liu, Yaosheng Chen, Zuyong He   +9 more
openalex   +1 more source

Single Administration of AAV‐mAtp6v1b2 Gene Therapy Rescues Hearing and Vestibular Disorders Caused by Atp6v1b2‐Induced Lysosomal Dysfunction in Hair Cells

Advanced Science, EarlyView.
Wei et al. establish a hair cell‐specific conditional knockout mouse model (Atp6v1b2fl/fl;Atoh1Cre/+), and demonstrate the importance of Atp6v1b2 for hair cell through maintaining the survival of lysosomes. A single administration of AAV‐ie‐Eh3‐mAtp6v1b2 through scala media at P0‐P2 realizes function compensation and restores hearing and balance ...
Gege Wei, Shiwei Qiu, Xue Gao, Lu Zheng, Yijin Chen, Ying Ma, Haifeng Feng, Jinyuan Yang, Guojie Dong, Huiyi Nie, Weihao Zhao, Xiaoge Li, Guangqin Wang, Wei Xiong, Pu Dai, Yongyi Yuan   +15 more
wiley   +1 more source

Recent Advancements in Lung Cancer Metastasis Prevention Based on Nanostrategies

Advanced Science, EarlyView.
Metastasis is the leading cause of death in patients with lung cancer. Nanomedicine can be used to prepare efficient drug delivery systems owing to their advantages and plays an important role in the synergistic antimetastasis of lung cancer. This comprehensive review summarizes the emerging nanostrategies against lung cancer metastasis based on the ...
Fan Xu, Yao Liu, Zujun Que, Bin Luo, Yun Yang, Yan Li, Zhanxia Zhang, Jianhui Tian   +7 more
wiley   +1 more source

Structural and thermodynamic analysis of compensating mutations within the core of chicken egg white lysozyme.

, 1992
Keith P. Wilson, Bruce A. Malcolm, Brian W. Matthews   +2 more
openalex   +1 more source