Versatile Cell Penetrating Peptide for Multimodal CRISPR Gene Editing in Primary Stem Cells
Advanced Functional Materials, EarlyView.CRISPR machinery in diverse molecular formats (DNA, RNA, and ribonucleic protein) is complexed into nanoparticles with the cell‐friendly arginine‐alanine‐leucine‐alanine (RALA) cell‐penetrating peptide. Nanoparticles are delivered to primary mesenchymal stem cells ex vivo or locally in vivo to facilitate multimodal CRISPR gene editing. This RALA‐CRISPR
Joshua P. Graham +9 more
wiley +1 more source
Advanced Functional Materials, EarlyView.This study demonstrates that cholesterol in messenger RNA‐lipid nanoparticles (mRNA‐LNPs) can be completely replaced with an immunopotentiating lipid, i.e., a synthetic analogue of the C‐type lectin receptor agonist monomycoloyl glycerol (MMG‐1), without compromising physicochemical properties, in vivo transfection efficiency, and immunogenicity of the
Abhijeet G. Lokras +19 more
wiley +1 more source
Prevalence and Predictors of BRCA1 and BRCA2 Mutations in a Population-Based Study of Breast Cancer in White and Black American Women Ages 35 to 64 Years [PDF]
, 2006 Kathleen E. Malone +21 more
openalex +1 more source
Biomaterial Strategies for Targeted Intracellular Delivery to Phagocytes
Advanced Functional Materials, EarlyView.Phagocytes are essential to a functional immune system, and their behavior defines disease outcomes. Engineered particles offer a strategic opportunity to target phagocytes, harnessing inflammatory modulation in disease. By tuning features like size, shape, and surface, these systems can modulate immune responses and improve targeted treatment for a ...
Kaitlyn E. Woodworth +2 more
wiley +1 more source
Alexander Disease-Associated Glial Fibrillary Acidic Protein Mutations in Mice Induce Rosenthal Fiber Formation and a White Matter Stress Response [PDF]
, 2006 Tracy L. Hagemann +2 more
openalex +1 more source
, 2020 Zeynep Coban‐Akdemir +25 more
openalex +1 more source
Advanced Functional Materials, EarlyView.High‐density BNNT films, enabling mechanical robustness and high space radiation shielding effectiveness, are fabricated using surfactant‐stabilized BNNT liquid crystal. Simulations indicate that a 50 g cm−2 BNNT film can reduce radiation exposure by 56% compared to zero shielding, potentially doubling the duration of astronaut missions on the lunar ...
Young‐Kyeong Kim +17 more
wiley +1 more source
Spotting the Pattern: A Review on White Coat Color in the Domestic Horse
AnimalsTraits such as shape, size, and color often influence the economic and sentimental value of a horse. Around the world, horses are bred and prized for the colors and markings that make their unique coat patterns stand out from the crowd.
Aiden McFadden +5 more
doaj +1 more source
Familial tumoral calcinosis and testicular microlithiasis associated with a new mutation of GALNT3 in a white family [PDF]
, 2006 Maria Francesca Campagnoli +9 more
openalex +1 more source
Advanced Functional Materials, EarlyView.This work utilizes poly(heptazine imides) as a model system to demonstrate how fine‐tuning the crystal structure influences the photocatalytic properties of layered carbon nitrides in the hydrogen evolution reaction. In particular, the nature of rotational defects and the hydration shell of cations are key contributors to enhanced hydrogen evolution ...
Diana V. Piankova +11 more
wiley +1 more source