Results 151 to 160 of about 704,012 (340)

A Determination of the Magnitude of the Cell “Sensitive Volume” Associated with the White-Eye Mutation in X-Rayed Drosophila—

, 1936
Caryl P. Haskins, E. V. Enzmann
openalex   +1 more source

C3H/HeJ mice carrying a toll-like receptor 4 mutation are protected against the development of insulin resistance in white adipose tissue in response to a high-fat diet [PDF]

, 2007
Marjorie Poggi, Delphine Bastelica, Philippe Gual, Miguel A. Iglesias, Thierry Grémeaux, Claude Knauf, Franck Peiretti, Monique Verdier, I. Juhan‐Vague, Jean‐François Tanti, Rémy Burcelin, Marie‐Christine Alessi   +11 more
openalex   +1 more source

Nanobody‐Decorated Lipid Nanoparticles for Enhanced mRNA Delivery to Tumors In Vivo

Advanced Healthcare Materials, EarlyView.
This study presents a targeted mRNA‐LNP platform engineered with anti‐PSMA nanobodies for prostate cancer therapy. Using different in vivo models, the authors demonstrate selective uptake and mRNA delivery in PSMA+ cancer cells. However, while targeting is enhanced, mRNA delivery efficacy is limited by tissue penetration, tumor necrosis, and immune ...
Pol Escudé Martinez de Castilla, Vincenzo Verdi, Willemijn de Voogt, Mariona Estapé Sentí, Arnold C. Koekman, Julian Rietveld, Sven van Kempen, Qiangbing Yang, Juliette van Merris, Guido Jenster, Martin E. van Royen, Marcel H. Fens, Sander A. A. Kooijmans, Wytske M. van Weerden, Guillaume van Niel, Pieter Vader, Raymond M. Schiffelers   +16 more
wiley   +1 more source

Biofabrication of a Filtration Barrier by Integrating Electrospun Membranes and Flow in a Glomerular Co‐Culture

Advanced Healthcare Materials, EarlyView.
An ex vivo glomerular filtration barrier is engineered using electrospun, biomimetic membranes seeded with human glomerular cells. The model supports fenestrated endothelium and podocyte foot processes under flow, mimics size‐selective filtration, and enables disease modeling with hiPSC‐derived podocytes, offering a powerful platform for studying ...
Camilla Mussoni, Anna Rederer, Vladimir Stepanenko, Frank Würthner, Philipp Stahlhut, Jürgen Groll, Mario Schiffer, Taufiq Ahmad, Janina Müller‐Deile   +8 more
wiley   +1 more source

Structural and thermodynamic analysis of compensating mutations within the core of chicken egg white lysozyme.

, 1992
Keith P. Wilson, Bruce A. Malcolm, Brian W. Matthews   +2 more
openalex   +1 more source

Identification of a novel nonsense mutation on the Pax3 gene in ENU-derived white belly spotting mice and its genetic interaction with c-Kit [PDF]

, 2010
Xiao-Li Guo, Hai‐Bin Ruan, Yan Li, Xiang Gao, Wei Li   +4 more
openalex   +1 more source

Integrin β4‐Enriched Small Extracellular Vesicle as Drug Delivery Vehicle for Targeting Pulmonary Metastasis of Hepatocellular Carcinoma

Advanced Healthcare Materials, EarlyView.
The expression of integrin β4 (ITGβ4) on small extracellular vesicle (sEV) correlates with lung‐tropism. Enrichment of ITGβ4 on sEVs enhances their lung‐targeting ability. The sEVs loaded with doxorubicin exhibit superior therapeutic efficacy in a lung metastasis mouse model.
Tung Him Ng, Aijun Liang, Maximus CF Yeung, Sze Keong Tey, Kam‐Leung Siu, Sin‐Yee Fung, Dong‐Yan Jin, Judy Wai Ping Yam   +7 more
wiley   +1 more source

High mutation rate in prolactin intron 2 regulates egg-laying performance in Wanjiang white goose [PDF]

, 2011
Jie Chen, Genlin Wang, Yafei Cai
openalex   +1 more source

Vascularized and Perfusable Human Heart‐on‐a‐Chip Model Recapitulates Aspects of Myocardial Ischemia and Enables Analysis of Nanomedicine Delivery

Advanced Materials, EarlyView.
This novel 3D human ischemic heart‐on‐a‐chip, with perfusable vasculature directly interfaced with myocardial tissue, replicates key aspects of ischemic heart injury. It also demonstrates the targeted delivery and therapeutic efficacy of cardiac homing peptide‐conjugated liposomes, validating the platform for drug and nanomedicine screening in ...
Junyoung Kim, Xuening Zhang, Richard Wang, Adrian Najer, Qiao You Lau, Ana Cammack‐Najera, Jang Ah Kim, Yoo Kyung Kang, Ruoxiao Xie, Hyemin Kim, Kai Xie, Hyeonji Lim, Tae‐Eun Park, Jinmyoung Joo, Molly M. Stevens   +14 more
wiley   +1 more source

Cutaneous white spots in a child with polycystic kidneys: a clue to TSC2/PKD1 gene mutation

, 2000
Markus Sperandio, Lutz W. D. Weber, A. Jauch, Bart Janssen, Otto Mehls, Franz Schaefer   +5 more
openalex   +1 more source