Results 151 to 160 of about 388,137 (254)

AAVR Expression is Essential for AAV Vector Transduction in Sensory Hair Cells

Advanced Science, EarlyView.
Decreased sensitivity to AAV vector transduction in the outer hair cells (OHCs) of adult mice is primarily attributed to reduction of AAVR (Kiaa0319l; Au040320). Knockout of AAVR reduces AAV vector transduction efficiency in both inner hair cells (IHCs) and OHCs in neonatal mice.
Fan Wu, Guisheng Chen, Rui Hu, Peiwen Liu, Jintao Lou, Wenji Zhao, Zuhong He, Suhua Sha, Yiqing Zheng   +8 more
wiley   +1 more source

Single Administration of AAV‐mAtp6v1b2 Gene Therapy Rescues Hearing and Vestibular Disorders Caused by Atp6v1b2‐Induced Lysosomal Dysfunction in Hair Cells

Advanced Science, EarlyView.
Wei et al. establish a hair cell‐specific conditional knockout mouse model (Atp6v1b2fl/fl;Atoh1Cre/+), and demonstrate the importance of Atp6v1b2 for hair cell through maintaining the survival of lysosomes. A single administration of AAV‐ie‐Eh3‐mAtp6v1b2 through scala media at P0‐P2 realizes function compensation and restores hearing and balance ...
Gege Wei, Shiwei Qiu, Xue Gao, Lu Zheng, Yijin Chen, Ying Ma, Haifeng Feng, Jinyuan Yang, Guojie Dong, Huiyi Nie, Weihao Zhao, Xiaoge Li, Guangqin Wang, Wei Xiong, Pu Dai, Yongyi Yuan   +15 more
wiley   +1 more source

α‐Synuclein Pathology Spreads in a Midbrain–Hindbrain Assembloid Model

Advanced Science, EarlyView.
A novel midbrain–hindbrain assembloid model demonstrates the spread of α‐synuclein pathology, a hallmark of Parkinson's disease, mimicking Braak's hypothesis. This model reveals how pathology propagates from the hindbrain to the midbrain, inducing synaptic changes and early signs of neuronal vulnerability. It offers an innovative platform for exploring
Gemma Gomez‐Giro, Daniela Frangenberg, Daniela Vega, Alise Zagare, Kyriaki Barmpa, Paul M. A. Antony, Graham Robertson, Rahman Sabahi‐Kaviani, Kristian Haendler, Nathalie Kruse, Florentia Papastefanaki, Rebecca Matsas, Malte Spielmann, Regina Luttge, Jens C. Schwamborn   +14 more
wiley   +1 more source

65 Characterization of genomic and social determinants of health in the TP53 mutational landscape of non-cancerous endometrium during the lifespan of Black and White individuals

, 2023
Eric Rios‐Doria, Elizabeth U. Parker, Brendan F. Kohrn, Elizabeth M. Swisher, Kemi M. Doll, Rosana Risques   +5 more
openalex   +1 more source

Inhibition of Aberrant Activated Fibroblast‐Like Synoviocytes in Rheumatoid Arthritis by Leishmania Peptide via the Regulation of Fatty Acid Synthesis Metabolism

Advanced Science, EarlyView.
LACK156‐173 is internalized into RA‐FLSs via CAPN2‐mediated endocytosis and inhibits the aggressive phenotype of RA‐FLSs by restoring dysregulated fatty acid synthesis metabolism mediated by overexpressed FASN. The findings suggest that targeting the restoration of fatty acid metabolism could potentially alleviate synovial invasion and joint damage in ...
Jianling Su, Xuemei Fan, Yaoyao Zou, Guangtao Fu, Shiqi Feng, Xiaoxue Wang, Yongmei Yu, Lin Li, Zhenhua Bian, Rongrong Huang, Linmang Qin, Jiping Chen, Qin Zeng, Kai Yan, Caiyue Gao, Zhexiong Lian, Xin Li, Yang Li   +17 more
wiley   +1 more source

Recent Advancements in Lung Cancer Metastasis Prevention Based on Nanostrategies

Advanced Science, EarlyView.
Metastasis is the leading cause of death in patients with lung cancer. Nanomedicine can be used to prepare efficient drug delivery systems owing to their advantages and plays an important role in the synergistic antimetastasis of lung cancer. This comprehensive review summarizes the emerging nanostrategies against lung cancer metastasis based on the ...
Fan Xu, Yao Liu, Zujun Que, Bin Luo, Yun Yang, Yan Li, Zhanxia Zhang, Jianhui Tian   +7 more
wiley   +1 more source

Targeting Replication Fork Processing Synergizes with PARP Inhibition to Potentiate Lethality in Homologous Recombination Proficient Ovarian Cancers

Advanced Science, EarlyView.
This study demonstrates that the resveratrol analogue, trans‐4,4′‐dihydroxystilbene (DHS), exhibits synergistic anti‐tumor activity with the PARP inhibitor talazoparib, inducing significant ovarian cancer cell death. The synergistic effect of this combination arises from the concurrent downregulation of homologous recombination factors and the ...
Ganesh Pai Bellare, Kshama Kundu, Papiya Dey, Krupa Thankam Philip, Nitish Chauhan, Muskan Sharma, Sankarsingh Kesharsingh Rajput, Birija Sankar Patro   +7 more
wiley   +1 more source

Somatic mutations of triple-negative breast cancer: a comparison between Black and White women

, 2020
Angela R. Omilian, Lei Wei, Chi-Chen Hong, Elisa V. Bandera, Song Liu, Thaer Khoury, Christine B. Ambrosone, Song Yao   +7 more
openalex   +2 more sources

HNF3α Targets Nckap1l and Promotes Renal Fibrosis Following Ischemia‐Reperfusion Injury

Advanced Science, EarlyView.
Hepatocyte Nuclear Factor 3 alpha (HNF3α) is significantly upregulated in renal tubular epithelial cells of CKD patients and fibrotic mice. Deletion of HNF3α mitigates IRI‐induced renal fibrosis, while overexpression worsens it. HNF3α directly regulates NCK‐associated protein 1‐like (Nckap1l), whose overexpression exacerbates fibrosis.
Ling Hou, Yan Guo, Shuang Xu, Mi Bai, Weidong Cao, Yue Zhang, Zhanjun Jia, Aihua Zhang   +7 more
wiley   +1 more source

Deciphering Auditory Hyperexcitability in Otogl Mutant Mice Unravels an Auditory Neuropathy Mechanism

Advanced Science, EarlyView.
By investigating auditory hyperexcitability in a mouse model for hereditary deafness, this study identified a subpopulation of afferent neurons of the auditory nerve marked by Otogl expression. Despite their apparently normal hearing, Otogl+/− mice display poor activation of afferent neurons processing loud sounds and an elevation of the middle the ear
Mathilde Gagliardini, Sabrina Mechaussier, Carolina Campos Pina, Monica Morais, Olivier Postal, Philippe Jean, Typhaine Dupont, Amrit Singh‐Estivalet, Shéhanie Udugampolage, Cyril Scandola, Elisabeth Verpy, Baptiste Libé‐Philippot, Talya C. Inbar, Joanna Schwenkgrub, Carla Maria Barbosa Spinola, Raphaël Etournay, Aziz El‐Amraoui, Brice Bathellier, Adeline Mallet, Sedigheh Delmaghani, Fabrice Giraudet, Christine Petit, Boris Gourévitch, Paul Avan, Nicolas Michalski   +24 more
wiley   +1 more source