Results 151 to 160 of about 717,864 (344)

C3H/HeJ mice carrying a toll-like receptor 4 mutation are protected against the development of insulin resistance in white adipose tissue in response to a high-fat diet [PDF]

, 2007
Marjorie Poggi, Delphine Bastelica, Philippe Gual, Miguel A. Iglesias, Thierry Grémeaux, Claude Knauf, Franck Peiretti, Monique Verdier, I. Juhan‐Vague, Jean‐François Tanti, Rémy Burcelin, Marie‐Christine Alessi   +11 more
openalex   +1 more source

3D In Vitro Models of Breast Cancer: Current Challenges and Future Prospects Toward Recapitulating the Microenvironment and Mimicking Key Processes

Advanced Biology, EarlyView.
In vitro cancer models are advantageous for studying important processes such as tumorigenesis, cancer growth, invasion, and metastasis. The complexity and biological relevance increase depending on the model structure, organization, and composition of materials and cells.
Kyndra S. Higgins, Ah Joung Yu, Cheryl T. Gomillion   +2 more
wiley   +1 more source

Amide‐Linked Local Anesthetics Alter Tumor Biology in a Complex Human Tissue Model of Non‐Small Cell Lung Adenocarcinoma

Advanced Biology, EarlyView.
Amide local anesthetics (LA) affect tumor burden in various preclinical studies, possibly via their anti‐inflammatory properties. However, a translation into clinical evidence is still lacking. The current study demonstrates that LA ‐ even at clinically relevant concentrations – exert a strong anti‐tumoral effect in a complex ex vivo model patient ...
Juliane Krömer, Sebastian Krämer, Ngoc Anh Hoang, Doreen Sittig, Isabella Metelmann, Uta‐Carolin Pietsch, Sebastian N. Stehr, Sonja Kallendrusch, Tobias Piegeler   +8 more
wiley   +1 more source

Structural and thermodynamic analysis of compensating mutations within the core of chicken egg white lysozyme.

, 1992
Keith P. Wilson, Bruce A. Malcolm, Brian W. Matthews   +2 more
openalex   +1 more source

Identification of a novel nonsense mutation on the Pax3 gene in ENU-derived white belly spotting mice and its genetic interaction with c-Kit [PDF]

, 2010
Xiao-Li Guo, Hai‐Bin Ruan, Yan Li, Xiang Gao, Wei Li   +4 more
openalex   +1 more source

Production of mutations in the white-spore strain

Fungal Genetics Reports, 1971
S. S. Wang, R. L. Phillips, J. M. Magill
openaire   +3 more sources

A Spatially Resolved View on the Aging Substantia nigra: An Exploratory Proteomic Study

Advanced Biology, EarlyView.
Although aging is the most important risk factor for several neurodegenerative diseases, the molecular effects of physiological aging are still understudied. By applying spatially‐resolved proteomic analyses of the human substantia nigra pars compacta, alterations in vesicular trafficking and mitochondrial proteins are observed, as well as reduced ...
Britta Eggers, Maximilian Hausherr, Michel Lim, Karin Schork, Bilhan Karacora, Robin Grugel, Martin Eisenacher, Isabel Gil Aldea, Peter Riederer, Manfred Gerlach, Katrin Marcus   +10 more
wiley   +1 more source

High mutation rate in prolactin intron 2 regulates egg-laying performance in Wanjiang white goose [PDF]

, 2011
Jie Chen, Genlin Wang, Yafei Cai
openalex   +1 more source

Versatile Cell Penetrating Peptide for Multimodal CRISPR Gene Editing in Primary Stem Cells

Advanced Functional Materials, EarlyView.
CRISPR machinery in diverse molecular formats (DNA, RNA, and ribonucleic protein) is complexed into nanoparticles with the cell‐friendly arginine‐alanine‐leucine‐alanine (RALA) cell‐penetrating peptide. Nanoparticles are delivered to primary mesenchymal stem cells ex vivo or locally in vivo to facilitate multimodal CRISPR gene editing. This RALA‐CRISPR
Joshua P. Graham, Jose Gabriel Castro, Lisette C. Werba, Joseph Amitrano, Luke Fardone, Kevin P. Francis, Anand Ramamurthi, Michael J. Layden, Helen O. McCarthy, Tomas Gonzalez‐Fernandez   +9 more
wiley   +1 more source

Cutaneous white spots in a child with polycystic kidneys: a clue to TSC2/PKD1 gene mutation

, 2000
Markus Sperandio, Lutz W. D. Weber, A. Jauch, Bart Janssen, Otto Mehls, Franz Schaefer   +5 more
openalex   +1 more source