Alexander Disease-Associated Glial Fibrillary Acidic Protein Mutations in Mice Induce Rosenthal Fiber Formation and a White Matter Stress Response [PDF]
Tracy L. Hagemann+2 more
openalex +1 more source
Zeynep Coban‐Akdemir+25 more
openalex +1 more source
Phase 1, First‐In‐Human, Single‐/Multiple‐Ascending Dose Study of Iluzanebart in Healthy Volunteers
ABSTRACT Objective To evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of iluzanebart, a fully human monoclonal antibody TREM2 (triggering receptor expressed on myeloid cells 2) agonist, after single‐ (SAD) and multiple‐ascending‐dose (MAD) administration.
Andreas Meier+8 more
wiley +1 more source
Familial tumoral calcinosis and testicular microlithiasis associated with a new mutation of GALNT3 in a white family [PDF]
Maria Francesca Campagnoli+9 more
openalex +1 more source
Universal Proteomic Signature After Exercise‐Induced Muscle Injury in Muscular Dystrophies
ABSTRACT Objective Several neuromuscular disorders (NMDs) are characterized by progressive muscle damage and are marked by the elevation of circulating muscle proteins from activity‐related injury. Despite a diverse array of genetic drivers, many NMDs share similar patterns of exercise intolerance and higher concentrations of muscle injury proteins ...
Mads G. Stemmerik+5 more
wiley +1 more source
C3H/HeJ mice carrying a toll-like receptor 4 mutation are protected against the development of insulin resistance in white adipose tissue in response to a high-fat diet [PDF]
Marjorie Poggi+11 more
openalex +1 more source
Occurrence, Risk Factors, and Prognosis of Acute Cerebral Microinfarcts in CADASIL
ABSTRACT Introduction Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is the most common monogenic cerebral small vessel disease in adults. This study investigates the occurrence, risk factors, and prognosis of acute cerebral microinfarcts (ACMIs) in patients with CADASIL.
Xuejiao Men+11 more
wiley +1 more source
Positively supercharged mGreenLatern protein is self‐assembled electrostatically with negatively charged zinc phthalocyanines to yield bio‐based photoactive materials in aqueous media. The addition of phthalocyanines results in the formation of large complexes fully quenching of the protein fluorescence. The results indicate an energy transfer from the
Sharon Saarinen+10 more
wiley +1 more source