Results 201 to 210 of about 694,722 (327)

Phenotypic effects of a fertility mutation in Norwgain White Sheep

, 2013
Norwegian White Sheep (NWS) is a synthetic breed that results from crosses between local Norwegian and foreign breeds. This breed is mainly kept for the meat production, and litter size is therefore a trait of large economic value. A mutation in the ovine GDF9 gene (c.1111G>A) on chromosome 5 was recently found to be associated with increased litter ...
openaire   +1 more source

Inverse Design of Highly Deformable Mechanical Metamaterial Based on Partitional Semi‐Random Optimization

Advanced Science, Volume 12, Issue 28, July 24, 2025.
This research presents a novel optimization method for the inverse design of flexible mechanical metamaterials, enhancing traditional strategies by evaluating deformation in subregions. Combining simulated annealing with a genetic algorithm, it improves design efficiency and enables customizable deformation paths.
Xueqing Cao, Zeang Zhao, Panding Wang, Shengyu Duan, Hongshuai Lei   +4 more
wiley   +1 more source

The DEC2‐SCN2A Axis is Essential for the Anticonvulsant Effects of Cannabidiol by Modulating Neuronal Plasticity

Advanced Science, EarlyView.
This study identifies DEC2 as a critical transcriptional repressor of Scn2a that directly binds E‐box motifs in its promoter to regulate neuronal plasticity and epileptogenesis. Functional manipulation of DEC2 alters seizure susceptibility in vivo. Cannabidiol enhances this repression, unveiling a novel DEC2‐SCN2A axis underlying its anticonvulsant ...
Huifang Song, Yifan Wang, Lili Wang, Chang Guo, Shiqi Liu, Yi Rong, Jiawen Tian, Chao Peng, Yuying Shao, Zhixiong Ma, Na Li, Jingliang Zhang, Zijun Peng, Xu Yan, Hangwei Fa, Xinyue Ma, Jie Dong, Jinping Ji, Chen Yang, Haocheng Chen, Jing Liang, Qi Sun, Yang Yang, Weining Ma, Zhuo Huang   +24 more
wiley   +1 more source

HFE mutations in patients with iron overload in Santa Catarina: a cross-sectional study. [PDF]

Sao Paulo Med J
Pagliosa CM, Franco VKB, Matias TS, Dias BV, Hoepers ATC.   +4 more
europepmc   +1 more source

Rictor Ameliorates Acute Antibody‐Mediated Rejection Following Kidney Transplantation by Suppressing Macrophage M1 Polarization Through p65‐NLRP3 Axis

Advanced Science, EarlyView.
This study elucidates the critical role of Rictor in macrophage activation in acute antibody‐mediated rejection (ABMR). Rictor increases K48‐linked ubiquitination of p65 by upregulating E3 ubiquitin ligase SOCS1, inhibiting transcriptional levels of NLRP3 and inflammasome activation.
Bin Ni, Chengcheng Yang, Junqi Zhang, Zhou Hang, Ming Zheng, Dengyuan Feng, Qinghuan Shen, Jinxu Miao, Xulin Sun, Li Sun, Baixin Shen, Min Gu, Zijie Wang   +12 more
wiley   +1 more source

Moyamoya syndrome in a patient with Aicardi-Goutières syndrome associated with a SAMHD1 mutation: a case report. [PDF]

Pediatr Radiol
Le Floch K, Barillon J, Bonanno MC, Héron B, Mignot C, Renaldo F, Chalard F.   +6 more
europepmc   +1 more source

Semaphorin 3E‐Plexin‐D1 Pathway Downstream of the Luteinizing Hormone Surge Regulates Ovulation, Granulosa Cell Luteinization, and Ovarian Angiogenesis in Mice

Advanced Science, EarlyView.
The Semaphorin 3E (Sema3E)‐Plexin‐D1 pathway mediated by C/EBPα and C/EBPβ downstream of the luteinizing hormone (LH) surge plays important roles in the mouse preovulatory ovary. Timely activation and suppression of this pathway during the preovulatory stage are crucial for ovulation, corpus luteum formation, and proper angiogenesis.
Hanxue Zhang, Jimmy Dhillon, Paul D. Soloway, Bo Shui, Seoyeon Lee, Jennifer K. Grenier, Paul R. Munn, M. Cecilia Ljungberg, Rebecca B Williams, Rainer B. Lanz, Yu‐Hsiang Liao, Yi A. Ren   +11 more
wiley   +1 more source

A case of coexisting heterozygous NOTCH3 and HTRA1 mutations in cerebral small vessel disease. [PDF]

Hum Genome Var
Yamashiro M, Yasutomi D, Ohya Y, Ohyama S, Takashima H, Tokashiki T.   +5 more
europepmc   +1 more source

Localized Delivery of the mRNAs Encoding CD47 Inhibitor and Interleukins 12, 15, and 21 Elicits Robust Antitumor Immunity

Advanced Science, EarlyView.
The co‐delivery of mRNAs encoding a CD47 inhibitor and a cytokine cocktail (interleukins 12, 15, and 21) via lipid nanoparticles enables effective localized immunotherapy. This strategy not only suppresses tumor progression but also enhances type 1 conventional dendritic cell (cDC1) differentiation and activates CD8+ T cells, thereby inducing robust ...
Tao Jiang, Shuaiyang Jing, Haojun Li, Bao Xiao, Jiahui Jin, Xiu Sun, Juan Wang, Jing Liang, Tongze Cai, Huili Hu, Meilan Wei, Xuanrui Zhong, Yang Ji, Peng George Wang, Jianlong Zhou   +14 more
wiley   +1 more source

Aeronautical Mutagenesis and Whole-genome Resequencing Reveal the Genetic Basis of Color Change in <i>Naematelia aurantialba</i>. [PDF]

Mycobiology
Zeng Y, Shen Z, Cao Y, Luo X, Yang L, Li R, Lu Q, Li R.   +7 more
europepmc   +1 more source