Results 211 to 220 of about 388,137 (254)

LncRNA‐MEG3 Regulates Muscle Mass and Metabolic Homeostasis by Facilitating SUZ12 Liquid–Liquid Phase Separation

Advanced Science, EarlyView.
This study has identified lncRNA‐MEG3 as a key regulator of muscle mass, promoting slow‐twitch muscle fibers and preventing muscle atrophy. By stabilizing the SUZ12/PRC2 complex through liquid–liquid phase separation (LLPS), lncRNA‐MEG3 influences mitochondrial function and lipid metabolism.
Yilong Yao, Chao Yan, Haibo Huang, Shilong Wang, Jiaying Li, Yun Chen, Xiaolu Qu, Qi Bao, Lingna Xu, Yuanyuan Zhang, Danyang Fan, Xia He, Yanwen Liu, Yongsheng Zhang, Yalan Yang, Zhonglin Tang   +15 more
wiley   +1 more source

Mutation of the white gene in Drosophila has broad phenotypic and transcriptomic effects

April Rickle, Karpagam Uma Sudhakar, Alix Booms, Ellen Stirtz, Adelheid Lempradl   +4 more
openalex   +1 more source

Mechanisms and Therapeutic Strategies for Minority Cell‐Induced Paclitaxel Resistance and Tumor Progression Mediated by Mechanical Forces

Advanced Science, EarlyView.
This study provides new perspectives into the interactions between mechanical forces and cellular dynamics within the tumor microenvironment, particularly elucidating how minority Paclitaxel‐resistant cancer cells (MRCs) promote tumor progression and treatment resistance through mechanical forces and also providing effective treatment strategies for ...
Xueyan Feng, Di Zhang, Guoxun Wang, Liwei Lu, Feng Feng, Xiuyu Wang, Chanchan Yu, Yahong Chai, Jin Zhang, Wenchao Li, Jing Liu, Hongxia Sun, Li Yao   +12 more
wiley   +1 more source

Population Genomics Reveals Elevated Inbreeding and Accumulation of Deleterious Mutations in White Raccoon Dogs

Yinping Tian, Yu Lin, Yue Ma, Jun Li, Sunil Kumar Sahu, Jiale Fan, Chen Lin, Zhiang Li, Minhui Shi, Fengping He, Lijun Bai, Yuan Fu, Zhangwen Deng, Huabing Guo, Haimeng Li, Qiye Li, Yanchun Xu, Tianming Lan, Zhijun Hou, Yanling Xia, Shuhui Yang   +20 more
openalex   +1 more source

Enhancing the Protein Stability of an Anticancer VHH‐Fc Heavy Chain Antibody through Computational Modeling and Variant Design

Advanced Science, EarlyView.
In this study, a computational pipeline is developed to systematically evaluate the conformational stability, disulfide bond reduction state, and aggregation and degradation tendencies of an anticancer VHH‐Fc fusion antibody. Based on the mechanistic insights, antibody variants with enhanced stability and increased yield are successfully designed. This
Yuan Fang, Menghua Song, Tianning Pu, Xiaoqing Song, Kailu Xu, Pengcheng Shen, Ting Cao, Yiman Zhao, Simon Hsu, Dongmei Han, Qiang Huang   +10 more
wiley   +1 more source

Novel NOTCH3 mutation c.1564 T > A (p.Cys522Ser) presenting with early-onset Parkinsonism and white matter lesions

Nicola Rifino, Silvia Baratta, Esteban Zacarias, Isabella Canavero, Benedetta Storti, Mario Stanziano, Emanuela Maderna, Gianluca Marucci, Franco Taroni, Anna Bersano   +9 more
openalex   +1 more source

Manipulating the Light Systemic Signal HY5 Greatly Improve Fruit Quality in Tomato

Advanced Science, EarlyView.
This study establishes that HY5, activated by low‐dose light, acts as a systemic signal to enhance tomato fruit quality by directly promoting carotenoid synthesis and sugar metabolism. These findings demonstrate HY5's mobility from leaves to fruits and its application potential through nighttime LED lighting, offering a practical strategy for crop ...
Jiachun Wang, Xiaomeng Li, Jiajia Li, Han Dong, Zhangjian Hu, Xiaojian Xia, Jingquan Yu, Yanhong Zhou   +7 more
wiley   +1 more source

Long QT Syndrome With Wolff-Parkinson-White Syndrome Resulting From a Novel Mutation in ANK2: A Case Report and Literature Review

Jian Li, Shixing Li, Chuang Zhang, Xiangmin Shi   +3 more
openalex   +1 more source

Engineered Genetic Circuits Activated by Bezafibrate Improve ESC‐Based TAA Cancer Vaccine Efficacy and PD‐L1 Nanobody Therapy

Advanced Science, EarlyView.
Synthetic gene circuits regulated by bezafibrate are developed to express tumor antigens and PD‐L1 nanobody (PD‐L1nb), enhancing cancer immunotherapy. Delivered via HEK293T cells, ESCs, or directly injected the plasmids containing the circuit into the tumor, the circuits reduce tumor growth, boost CD8+ T cells, and minimize T cell exhaustion.
Meiling Jin, Shuzhen Liu, Mingshuo Zhan, Jian‐Dong Huang   +3 more
wiley   +1 more source

Replicating PET Hydrolytic Activity by Positioning Active Sites with Smaller Synthetic Protein Scaffolds

Advanced Science, EarlyView.
A workflow is proposed for the computational design of new‐to‐nature PET hydrolases by remodeling the protein scaffold. Starting from the functional motifs extracted from a template enzyme, designer enzymes are generated following four steps: scaffold remodeling, computational screening, experimental validation, and sequence refinement.
Yujing Ding, Shanshan Zhang, Xian Kong, Henry Hess, Yifei Zhang   +4 more
wiley   +1 more source