Results 241 to 250 of about 694,722 (327)

Heterozygous deletion of exon 17 of the Kit gene impairs mouse spermatogenesis by attenuating MAPK-ERK signaling. [PDF]

Biol Res
Lin S, Yang M, Zhu W, Yang C, Chen Y, Cong P, Liu X, He Z.   +7 more
europepmc   +1 more source

Human Schlafen 14 Cleavage of Short Double‐Stranded RNAs Underpins its Antiviral Activity

Advanced Science, EarlyView.
SLFN14 is associated with human diseases. SLFN14 is found to cleave RNAs containing short duplexes. The cryo‐EM structures of SLFN14 and SLFN14‐hairpin RNA complex reveal that SLFN14 assembles into a ring‐like dimer; two RNase domains form an RNA‐binding groove accommodating a hairpin RNA.
Mengyun Li, Dapeng Sun, Wei Hao, Hua Fu, Yueli Zhang, Zhijian Li, Bo Qin, Yumei Wang, Sheng Cui   +8 more
wiley   +1 more source

Differential Diagnosis and a Novel Mutation in Birt-Hogg-Dubé Syndrome: Insights from 2 Cases. [PDF]

Am J Case Rep
Tu L, Ye Y, Zhou J, Pan Z.
europepmc   +1 more source

The SlDOF9‐SlSWEET17 Module: a Switch for Controlling Sugar Distribution Between Nematode Induced Galls and Roots in Tomato

Advanced Science, Volume 12, Issue 28, July 24, 2025.
Root‐knot nematode (RKN) disease seriously affects the yield and quality of vegetable crops. SlDOF9‐SlSWEET17 model helps plants resist RKN infection during early stage by switching off the sugar transport capacity of other SlSWEET proteins that are hijacked by RKNs.
Xiaoyun Wang, Zhimei Wang, Xinyue Tang, Jiamei Qin, Xiaoxuan Zhou, Lixia Gu, Huihui Bian, Lulu Sun, Huang Huang, Rui Yang, Jianli Wang, Shaohui Wang, Shuangchen Chen, Zhongren Yang, Wenchao Zhao   +14 more
wiley   +1 more source

Identifying PRKAG2 syndrome-a rare cause of wolff-Parkinson-white syndrome and left ventricular hypertrophy: a case report. [PDF]

Eur Heart J Case Rep
Jang JH, Baek YS, Jang WR, Kim DY, Shin SH.   +4 more
europepmc   +1 more source

Mutations in Insulin-Receptor Gene: Val996 Allele in White NIDDM Patients

Diabetes Care, 1992
PORCELLINI, ANTONIO, COCOZZA, SERGIO, A. Monticelli, L. Pianese, RICCARDI, GABRIELE, A. Ferrara, S. Varrone   +6 more
openaire   +4 more sources

Novel ATR/PARP1 Dual Inhibitors Demonstrate Synergistic Antitumor Efficacy in Triple‐Negative Breast Cancer Models

Advanced Science, EarlyView.
Novel ATR/PARP1 dual inhibitors are developed for the first time. Advanced lead B8 effectively reduces cell viability in vitro and suppresses tumor growth in vivo, with better potency than ATRi and PARPi alone or in combination. Mechanistically, B8 induces apoptosis, arrests the cell cycle, and inhibits cancer cells colony formation, migration, and ...
Yuan Gao, Jiawei Zhou, Chen‐Chen Wang, Zong‐Hao Wang, Nian‐Dong Mao, Meng‐Lan He, Peng‐Peng Zhang, Ping Huang, Guo‐Wei Ye, Yu‐Qing Zhang, Feng‐Hui Tang, Hang Zhang, Tian Xie, Xiang‐Yang Ye   +13 more
wiley   +1 more source

Adult-Onset Alexander Disease: A Case Report and Literature Review of Glu207 Alterations. [PDF]

Cureus
Vallamchetla SK, Abdelkader O, Tuna IS, Barsamyan G, Shuhaiber H.   +4 more
europepmc   +1 more source

Novel Cyano‐Artemisinin Dimer ZQJ29 Targets PARP1 to Induce Ferroptosis in Pancreatic Cancer Treatment

Advanced Science, EarlyView.
A novel artemisinin derivative dimer has been synthesized, and its significant potential as an anti‐cancer agent. The study indicated that ZQJ29 effectively inhibited the proliferation of pancreatic cancer cells in vitro and in vivo. Additionally, these investigations have unveiled ZQJ29 as a new potent PARP1 inhibitor, with the capability to induce ...
Jianping Chen, Lingyun Yue, Yanna Pan, Bingying Jiang, Junfeng Wan, Haixia Lin, Fujiang Guo, Huiyu Li, Yajuan Li, Qingjie Zhao   +9 more
wiley   +1 more source

B cell dysfunction in thalamus and brainstem involvement and high lactate caused by novel mutation of EARS2 gene. [PDF]

Ital J Pediatr
Wen Y, Huang Y, Zhang W, Chen P, Hu X, Xiong X, Luo L.   +6 more
europepmc   +1 more source