Results 251 to 260 of about 717,864 (344)

Preservation of ALYREF Phase Separation Mitigates Doxorubicin‐Induced Cardiomyocyte DNA Damage and Cardiotoxicity

Advanced Science, EarlyView.
Binding of Doxorubicin to ALYREF disrupts its phase‐separated condensate and induces DNA damage and apoptosis in cardiomyocytes Abstract The clinical utility of the anticancer agent doxorubicin (DOX) is limited by its dose‐dependent cardiotoxicity.
Xinlu Gao, Yifu Shen, Zhihui Xiao, Zhenbo Han, Xu Liu, Ao Cai, Yanan Tian, Guang Lian, Wenya Ma, Yining Liu, Rui Gong, Hanjing Li, Xiuxiu Wang, Zhongyu Ren, Naufal Zagidullin, Lei Yu, Ye Tian, Yu Liu, Zhenwei Pan, Baofeng Yang, Benzhi Cai   +20 more
wiley   +1 more source

Targeting MET and KRAS G12C co-occurring mutation in metastatic adenoid cystic carcinoma of the trachea: a case report. [PDF]

J Med Case Rep
Zhang L, Wang T, Xu Y, Ji Y, Nie K.
europepmc   +1 more source

Look out for the white lesions in DOCK-8 (c. 5963 c>t) immunodeficiency – A novel mutation

Rhea Ahuja, Ritu Sharma, Sudheer Arava, Neetu Bhari   +3 more
openalex   +1 more source

A Mutation at the I Locus in an Inbred Line of White Leghorns and its Effect on Growth Rate

, 1962
Carol Blackwood, B.B. Bohren, Henry Mckean   +2 more
openalex   +1 more source

Quantitative Profiling of Nanoscopic Protein Aggregates Reveals Specific Fingerprint of TDP‐43‐Positive Assemblies in Motor Neuron Disease

Advanced Science, EarlyView.
Single‐molecule fluorescence microscopy is combined with proteomic profiling to fingerprint the morphology and composition of TDP‐43 protein aggregates found in post‐mortem motor neuron disease brain tissues. Aggregate fingerprints can distinguish disease from control donors and detect unexpected TDP‐43 pathology in SOD1‐MND.
Dezerae Cox, Melanie Burke, Sara Milani, Matthew A White, Fergal M Waldron, Dorothea Böken, Evgeniia Lobanova, Jemeen Sreedharan, Jenna M Gregory, David Klenerman   +9 more
wiley   +1 more source

Correction to: Comorbidities in early-onset sporadic versus presenilin-1 mutation-associated Alzheimer disease dementia: Evidence for dependency on Alzheimer disease neuropathological changes. [PDF]

J Neuropathol Exp Neurol
europepmc   +1 more source

PRMT5 genetic interactions with DNA double strand break repair genes. [PDF]

PLoS One
Bliss HJ, Tron J, Bush W, Bouley RA, Petreaca RC.   +4 more
europepmc   +1 more source

THE GENETICS OF ARTEMIA SALINA. II. WHITE EYE, A SEX-LINKED MUTATION

, 1963
Sarane T. Bowen
openalex   +2 more sources

NADPH Oxidase Inhibition Promotes Brain Resilience by Attenuating Tauopathy and Neuroinflammation in Alzheimer's Disease

Advanced Science, EarlyView.
CRB‐2131, as a novel Nox inhibitor, suppresses brain oxidation, tauopathy, and neuro‐inflammation, thereby preventing death of mature neurons and promoting regeneration of immature neurons. Ultimately, this fosters a resilient brain and protects cognition.
Jihyeon Lee, Seunghwan Sim, Yinglan Jin, Hyejun Park, Eun Young Byeon, Su Jin Kim, Sujin Yun, Hye Eun Lee, Da Un Jeong, Jung Min Suh, In Hye Lee, Ho‐Young Lee, Yongseok Choi, Yun Soo Bae   +13 more
wiley   +1 more source

A case of ADH5/ALDH2 deficiency combined with 3q29 microduplication syndrome. [PDF]

BMC Pediatr
Chenzhuo S, Lingling F, Ang W, Hui C, Ruixin W, Bixi Y, Hongmin L, Jie M, Tianyou W.   +8 more
europepmc   +1 more source