Results 251 to 260 of about 704,012 (340)

Conversational AI agent for precision oncology: AI-HOPE-WNT integrates clinical and genomic data to investigate WNT pathway dysregulation in colorectal cancer. [PDF]

Front Artif Intell
Yang EW, Waldrup B, Velazquez-Villarreal E.   +2 more
europepmc   +1 more source

Weak and Tunable Adhesion–Clutch Drives Rapid Cell Migration and Glioblastoma Invasion

Advanced Science, EarlyView.
This study proposes that adhesion–clutch can mediate both cell motility and immobilization depending on the force amplitude. Weak adhesion–clutch is well‐suited for cell migration, without forming strong adhesions that impede cell motility. It propels rapid dendritic cell migration controlled by extracellular chemicals, as well as pathologically ...
Kentarou Baba, Ami Fukushi‐Kumagai, Megumi Morisaki, Ryosuke Takeuchi, Zhize Xiao, Yoshikazu Nagashima, Mizuki Sakai, Yasuna Higashiguchi, Hiroko Katsuno‐Kambe, Asako Katsuma, Yoshihiro Ueda, Yuji Kamioka, Daisuke Kawauchi, Tatsuo Kinashi, Yonehiro Kanemura, Naoyuki Inagaki   +15 more
wiley   +1 more source

A dominant SRCAP truncating mutation promotes squamous cell carcinoma progression. [PDF]

Oncogenesis
Droll SH, Dewar EIO, Xue C, Levine MC, Zhang BJ, Bao X.   +5 more
europepmc   +1 more source

Coupling antitoxins and blue/white screening with parAB /resolvase mutation as a strategy for Salmonella spp. plasmid curing

Dereje D. Gudeta, Shaohua Zhao, Nesreen Aljahdali, Steven L. Foley   +3 more
openalex   +1 more source

Lithium Exposure Causes Trophoblast Cuproptosis by Upregulating FOXO1/STEAP4 Axis in Unexplained Miscarriage

Advanced Science, EarlyView.
Li exposure up‐regulates FOXO1 expression levels and thus promotes FOXO1‐mediated STEAP4 transcription, up‐regulating STEAP4 levels. Subsequently, STEAP4 up‐regulates intracellular Cu+ ion levels and causes cuproptosis, which further induces miscarriage.
Shuaishuai Xing, Yanbing Lin, Yi Sun, Xiaoping Yue, Qigang Fan, Jisheng Nie, Zhihong Zhang, Yajing Liu, Juntang Yang, Qingzheng Kang, Yanxin Wang, Haijun Yan, Chan Tian, Ying Chang, Huidong Zhang   +14 more
wiley   +1 more source

Multifocal intra-cranial masses: Late presentation of an uncommon histiocytic disorder. [PDF]

Radiol Case Rep
Purkiss D, Xu D, Borecky L, Achiriloaie A, Hurth K, Yamamoto A, Raghavan R.   +6 more
europepmc   +1 more source

Vanishing White Matter Disease in Children: An Unusual Association, a Novel Mutation, and a Literature Review

Zahra Alsahlawi, Hasan M Isa, Sulaiman Alresias, S. M. Naimul Hasan, Husain Malalla, Ayman Khalil Ebrahim, Khadija Ali   +6 more
openalex   +1 more source

Comprehensive Characterization of the Immune Microenvironment Based on Nested Resampling Machine Learning Framework Identifies TRAF3 Interacting Protein 3 as a Promising Regulator to Improve the Resistance to Immunotherapy in Glioma

Advanced Science, EarlyView.
This study develops a nested resampling machine learning framework to establish the Immune Glioma Survival Signature (IGLoS), which stratifies glioma patients and predicts immunotherapy resistance. Multi‐omics analyses reveal TRAF3IP3 as a pivotal regulator of PD‐L1 expression and T‐cell exhaustion via ERK‐NFATC2 signaling.
Yanbo Yang, Fei Wang, Yulian Zhang, Run Huang, Chuanpeng Zhang, Lu Zhao, Hanhan Dang, Xinyu Tao, Yue Lu, Dengfeng Lu, Yunsheng Zhang, Kun He, Jiancong Weng, Zhouqing Chen, Zhong Wang, Yanbing Yu   +15 more
wiley   +1 more source