Results 261 to 270 of about 717,864 (344)

Coupling antitoxins and blue/white screening with parAB /resolvase mutation as a strategy for Salmonella spp. plasmid curing

Dereje D. Gudeta, Shaohua Zhao, Nesreen Aljahdali, Steven L. Foley   +3 more
openalex   +1 more source

Pathogenicity of Mediator Complex Subunit 27 (MED27) in a Neurodevelopmental Disorder with Cerebellar Atrophy

Advanced Science, EarlyView.
MED27 is one of the 26 subunits in the human Mediator complex (MED). Neurodevelopmental disorder‐causing MED27 genetic variants induce instability of MED, leading to disrupted DNA occupancy, altered chromatin interaction, and subsequent transcriptional dysregulation of critical downstream genes, including master regulatory transcription factors ...
Nuermila Yiliyaer, Xiaocheng Li, Tianyu Guo, Haiying Zhou, Lihai Gong, Luowei Yuan, Yang Fu, Yulong Qiao, Ying Lam Lui, Nuo Chen, Pengfei Lin, Hoi Hung Cheung, Ho Ko, Linyan Meng, Xiao Chen, Yong Lei, Kin Ming Kwan, Huating Wang, Shen Gu   +18 more
wiley   +1 more source

A 14-bp motif in the KIT active promoter region is critical for melanin accumulation in yaks, mice, and humans. [PDF]

BMC Biol
Liu X, Wang T, Zheng Z, Dong C, Liu W, Niu Z, Yang Y, Wu X, Qiu Q, Yang Y, Li K, Lenstra JA, Yan P, Kang M, Li B, Fang L, Liu J.   +16 more
europepmc   +1 more source

Vanishing White Matter Disease in Children: An Unusual Association, a Novel Mutation, and a Literature Review

Zahra Alsahlawi, Hasan M Isa, Sulaiman Alresias, S. M. Naimul Hasan, Husain Malalla, Ayman Khalil Ebrahim, Khadija Ali   +6 more
openalex   +1 more source

TSHR‐Targeting Nucleic Acid Aptamer Treats Graves' Ophthalmopathy via Novel Allosteric Inhibition

Advanced Science, EarlyView.
This study presents YC3, a novel inhibitory TSHR‐targeting aptamer, as a promising therapeutic for Graves' ophthalmopathy (GO). YC3 suppresses pathological phenotypes in human orbital fibroblasts and improves outcomes in GO mice by binding to a previously unidentified allosteric site on TSHR, demonstrating the potential of aptamers in advancing ...
Yanchen Zhang, Ende Wu, Weibin Liu, Ling Zeng, Neng Ling, Hongmei Wang, Zhixing Li, Shuang Yao, Tonghe Pan, Xuanwen Li, Yate Huang, Xiaojing Li, Yunhai Tu, Wentao Yan, Jianzhang Wu, Mao Ye, Wencan Wu   +16 more
wiley   +1 more source

Clinical characteristics of mycoplasma pneumoniae pneumonia in children with 23 S rRNA mutations in domain V and exploration of the timing of glucocorticoid therapy. [PDF]

BMC Infect Dis
Shen R, Zhou L, Chen Y, Chen Y, Yang S.
europepmc   +1 more source

Long QT Syndrome With Wolff-Parkinson-White Syndrome Resulting From a Novel Mutation in ANK2: A Case Report and Literature Review

Jian Li, Shixing Li, Chuang Zhang, Xiangmin Shi   +3 more
openalex   +1 more source

Gene Editing of a Susceptibility LncRNA Enhances Broad‐Spectrum Disease Resistance in Rice without Developmental Trade‐Offs

Advanced Science, EarlyView.
Editing susceptibility lncRNAs offers a strategy to enhance disease resistance without yield loss. RESIS, a domestication‐acquired, pathogen‐induced lncRNA, promotes protein N‐terminal acetylation through its interaction with NatA complex. Knockout of RESIS increases translation and confers broad‐spectrum resistance to both fungal and bacterial ...
Wen‐long Zhao, Ye Cheng, Jia‐hui Huang, Jun‐jie Feng, Hui‐yin Pang, Yi‐chao Qin, Zheng‐tong Chen, Yu Cheng, Jian‐ping Lian, Yan‐fei Zhou, Rui‐rui He, Meng‐qi Lei, Zi‐qin Cao, Lu Yang, Chao Yuan, Jie Jiang, Yue‐qin Chen, Yu‐chan Zhang   +17 more
wiley   +1 more source

More than meets the eye: mutation of the white gene in Drosophila has broad phenotypic and transcriptomic effects. [PDF]

Genetics
Rickle A, Sudhakar K, Booms A, Stirtz E, Lempradl A.   +4 more
europepmc   +1 more source

Population Genomics Reveals Elevated Inbreeding and Accumulation of Deleterious Mutations in White Raccoon Dogs

Yinping Tian, Yu Lin, Yue Ma, Jun Li, Sunil Kumar Sahu, Jiale Fan, Chen Lin, Zhiang Li, Minhui Shi, Fengping He, Lijun Bai, Yuan Fu, Zhangwen Deng, Huabing Guo, Haimeng Li, Qiye Li, Yanchun Xu, Tianming Lan, Zhijun Hou, Yanling Xia, Shuhui Yang   +20 more
openalex   +1 more source