Results 261 to 270 of about 731,846 (342)

Modifying Glucose Metabolism Reverses Memory Defects of Alzheimer's Disease Model at Late Stages

Advanced Science, EarlyView.
Using spatial transcriptomics, we show that ferul enanthate (SL‐ZF‐01) reverses episodic‐like memory deficits in aged, but not young, Alzheimer’s disease (AD) mice. SL restores glucose metabolism and Glucose Transporter 1/3 expression via an ‘Aging‐AD‐Rescue’ pattern, rescuing deficits seen in aged AD mice.
Fang Liu, Yiyu‐Li Tang, Zong‐Bo Zhang, Ya‐Hong Tan, Si‐Hui Lin, Ni‐Ya Wang, Jin‐Nan Li, Zhi‐Jie Pan, Jian‐Feng Li, Jing‐Fei Huang, Yu‐Qiang Ding, Chun‐Ming Guo, Lin Xu, Cheng Peng, Qi‐Xin Zhou   +14 more
wiley   +1 more source

BCR::ABL1-positive chronic myeloid leukaemia in a scenario of a remote diagnosis of JAK2-V617F-mutated polycythemia vera: a single patient experience with imatinib and ruxolitinib combination therapy. [PDF]

Ann Hematol
Bartolucci P, Gigli F, Tabanelli V, Valeriano A, Gregato G, Poletti C, Bertolini F, Derenzini E.   +7 more
europepmc   +1 more source

Iron Overload Mediates the Differential Cell Fate of Astrocytes from Neurons and Its Regulatory Mechanisms in Ischemic Stroke

Advanced Science, EarlyView.
Upon ischemia/reperfusion‐induced iron overload condition, neurons and astrocytes exhibit similar oxidative stress changes but opposite alterations in endogenous antioxidant defense mechanisms, leading to divergent ferroptotic outcomes. The iron deposition and neuronal loss are increased within the perilesional cortex of stroke patients ...
Yi Guo, Yue Wang, Yong Ni, Bin Bo, Jinzhi He, Yongming Zhu, Aiping Qin, Xianyong Zhou, Huaping Du, Yuan Liu, Tianyao Wang, Yudu Li, Yibo Zhao, Zengai Chen, Zhipei Liang, Yao Li, Yuan Xu, Huiling Zhang   +17 more
wiley   +1 more source

Two Cases of Epidermal Growth Factor Receptor L861R Mutation-Positive Lung Adenocarcinoma Treated With Osimertinib and Afatinib. [PDF]

Cancer Rep (Hoboken)
Kagawa K, Masuda T, Shimoji K, Yamaguchi K, Sakamoto S, Horimasu Y, Nakashima T, Iwamoto H, Hamada H, Hattori N.   +9 more
europepmc   +1 more source

Chromatin Topology Reconfiguration Orchestrates Thermotolerant Male Fertility via GhAL5 in Cotton

Advanced Science, EarlyView.
This study investigates cotton’s high‐temperature (HT) response using multi‑omics. Dynamic 3D genome changes drive expression bias affecting male fertility. The tolerant line shows controlled chromatin dynamics, while the sensitive line exhibits overactivation.
Yanlong Li, Jing Yang, Weiran Wang, Chunyang Zuo, Liuling Pei, Yizan Ma, Rui Zhang, Yaru Fan, Huanhuan Ma, Yawei Li, Ruizhen Liu, Shuangxia Jin, Longfu Zhu, Jie Kong, Xianlong Zhang, Ling Min   +15 more
wiley   +1 more source

Oral Exposure to Food‐Grade Nanoparticles Poses a Risk of Alzheimer's Disease‐Like Symptoms by Triggering Autophagy Defects in Neurons

Advanced Science, EarlyView.
Three food‐grade nanomaterials induce dysregulated RyR‐Ca2+ signaling through epigenetic modifications. This dysregulation impairs the autophagic clearance process, ultimately leading to abnormal Aβ deposition and increase phosphorylated tau levels.
Jiaxin Shang, Jun Yan, He Lou, Xuanxi Jiang, Ziyue Wang, Yue Gao, Xiaohui Fan, Xiaoyan Lu   +7 more
wiley   +1 more source

Racial disparities in clonal hematopoiesis and their impact on hematologic malignancies. [PDF]

J Hematol Oncol
Zhang Z, Cheng C.
europepmc   +1 more source

Regulating Tumor Metabolic Reprogramming with Biomimetic Co‐Delivery of Simvastatin and Kynureninase for Immunotherapy

Advanced Science, EarlyView.
After the intravenous injection of biomimetic and pH/ROS‐responsive PTSK@CRM, the nanoparticles can be accumulated in tumors and release Sim and KYNase to inhibit the tumor growth, regulate the metabolism of cholesterol and Kyn, and reverse the immunosuppressive tumor microenvironment.
Jiaxin Yin, Shengcai Yang, Zengguang Liu, Songchen Zhao, Siyu Sun, Ziling Liu, Quanshun Li   +6 more
wiley   +1 more source

Genetic Mapping and Phenotypic Characterization of the <i>Drosophila</i> <i>AIF ^e04281</i> Allele Reveals Mutant Clone Loss in Mosaic Eyes. [PDF]

MicroPubl Biol
Harris R, Prasad I, Weaver SE, Abdulrab A, Abernathy AA, Ackerman A, Acosta A, Aguirre A, Al Wakeel H, Alachkar F, Alfaro S, Allen B, Anderson A, Araiza A, Arroyo K, Arshad K, Artis S, Baqa MW, Bauer HE, Beduhn PL, Boylan G, Brahmbhatt V, Brock M, Bryant R, Byrne C, Carreno R, Conteh A, Cox K, Daniel EM, Drammeh M, Espino B, Farmer N, Fields A, Flores Santizo R, Gisele S, Goolsby MI, Grant EA, Graves X, Greenlaw G, Guelde L, Hall J, Hall J, Harris Z, Henry SM, Hensley M, Hurd K, Jolley M, Kalaj EA, Kallan A, Kaur R, Key C, Klesch M, Kocher P, Long A, Lopez M, Lucas Ii JJ, Luth JX, Marcinkowski SD, Martinez G, Martinez K, McCray-Brown C, McDermott L, McVay M, Middleton S, Milla A, Mobley J, Moore RL, Morris I, Newman MA, Nwoke IC, Perez A, Phillips KD, Ramirez M, Ramos E, Reda A, Redmond C, Rentchler M, Rider RS, Roschi A, Rouf SA, Scott L, Shah K, Shin CE, Smith L, Spahiu A, St Cloud J, Truitt I, Tucker C, Tyler KE, Underwood Z, Vaughn C, Vazquez L, Weiss M, Whitehead J, Williams A, Williams F, Pezdek MN, Shah HP, Devergne O, Peister A, Stamm J, Kagey JD, Merkle JA.   +102 more
europepmc   +1 more source