Results 271 to 280 of about 694,722 (327)

Differential splicing of COL4A5 mRNA in kidney and white blood cells: A complex mutation in the COL4A5 gene of an Alport patient deletes the NC1 domain

, 1993
Caiying Guo, Boudewijn Van Damme, Rita Van Damme‐Lombaerts, Herman Van den Berghe, J.J. Cassiman, Peter Marynen   +5 more
openalex   +1 more source

Podocyte RIPK3 Deletion Improves Diabetic Kidney Disease by Attenuating NF‐κB p65 Driven Inflammation

Advanced Science, EarlyView.
Prevention and treatment of diabetic kidney disease (DKD) have become a major global public health challenge. This study shed new light on the underlying pathogenic mechanisms of podocyte injury in DKD and highlights the therapeutic potential of mitigating podocyte injury through inhibition of the RIPK3/NF‐κB p65‐mediated inflammatory response as a ...
Lu'an Li, Jiaying Li, Ruizhao Li, Xingchen Zhao, Yuanhan Chen, Yating Cai, Yan Yang, Weiteng Wang, Siqi Zheng, Li Zhang, Xinling Liang   +10 more
wiley   +1 more source

Lipid Droplet‐Organized MDM2‐Mediated P53 Degradation: A Metabolic Switch Governing Diet‐Driven Tumor Progression

Advanced Science, EarlyView.
Tumor‐associated TP53 inactivation correlates with lipid droplet (LD) accumulation. High‐fat diets drive Cyb5r3‐Myh9‐mediated p53 enrichment on LD surfaces, accelerating its degradation while upregulating LD‐promoting factor CD36 expression to establish a feed‐forward loop. LD suppression or dietary intervention restores p53 and inhibits tumorigenesis,
Haiyang Liu, Lin Jing, Yixin Li, Jinxing Zhou, Xiaohui Cui, Sen Li, Shijie Yang, Fangming Kan, Junfeng Du, Wentao Zhong, Sheng Yu, Ning Wang, Xing Jia, Junhui Li, Pan Nie, Zhenzhong Chen, Ying Han, Lingxi Jiang, Xiyun Yan, Hongxia Duan, Baiyong Shen   +20 more
wiley   +1 more source

The genetic mapping and phenotypic analysis of <i>Patronin ^F.1.1</i> in <i>Drosophila melanogaster</i>. [PDF]

MicroPubl Biol
Gruber L, Soto I, Correa T, Apodaca E, Arreola B, Cabral J, Chen K, Correo Galicia M, Gomez J, Hao E, Hernandez B, Holland DL, Jara-Pichardo C, Lonzame GM, Ortiz Olguin A, Romero R, Walker D, Amacher SG, Christie C, Coats LG, Gerhardt A, Holsted CA, Kraizel SR, Krumlaw A, Stevens A, Stover H, Sullivan CM, Wyse H, Hamill DR, Kagey JD, Bieser KL.   +30 more
europepmc   +1 more source

Look out for the white lesions in DOCK-8 (c. 5963 c>t) immunodeficiency – A novel mutation

Rhea Ahuja, Ritu Sharma, Sudheer Arava, Neetu Bhari   +3 more
openalex   +1 more source

PIM1 Attenuates Innate Immunity to Foster Coronavirus Replication through Ubiquitin Ligase β‐TrCP‐Mediated IFNAR1 Degradation

Advanced Science, EarlyView.
Hijacking Host Kinase PIM1: A β‐Coronavirus (OC43) strategy to degrade IFNAR1 and evade antiviral immunity. Human β‐coronaviruses (OC43) exploit the proto‐oncoprotein PIM1 kinase to sabotage innate immunity. Viral RNA/proteins upregulate PIM1, which phosphorylates E3 ligase β‐TrCP1.
Qianya Wan, Lin Zhu, Cien Chen, Li Zhong, Houying Leung, Wei Li, Chang Xu, Xi Yao, Huan Hu, Mandi Wu, Yuxin Hou, Hin Chu, Yiran Wang, Sheng Chen, Mingyu Pan, Zongwei Cai, Ming‐liang He   +16 more
wiley   +1 more source

Progression of biological markers in spinocerebellar ataxia type 3: longitudinal analysis of prospective data from the ESMI cohort. [PDF]

Lancet Reg Health Eur
Berger M, Garcia-Moreno H, Ferreira M, Hubener-Schmid J, Schaprian T, Wegner P, Elter T, Teichmann KM, Santana MM, Grobe-Einsler M, Oender D, Koyak BSC, Bernsen S, Pereira de Almeida L, Silva P, Ribeiro JA, Cunha I, Gonzalez-Robles C, Khan S, Heslegrave A, Zetterberg H, Lima M, Raposo M, Ferreira AF, Vasconcelos J, van de Warrenburg BP, van Gaalen J, van Prooije TH, de Vries J, Schols L, Riess O, Synofzik M, Timmann D, Thieme A, Erdlenbruch F, Infante J, Pelayo-Negro AL, Manrique L, Reetz K, Dogan I, Oz G, Joers JM, Bushara K, Onyike C, Povazan M, Jacobi H, Schmahmann JD, Ratai EM, Schmid M, Giunti P, Klockgether T, Faber J.   +51 more
europepmc   +1 more source

Vanishing White Matter Disease in Children: An Unusual Association, a Novel Mutation, and a Literature Review

Zahra Alsahlawi, Hasan M Isa, Sulaiman Alresias, S. M. Naimul Hasan, Husain Malalla, Ayman Khalil Ebrahim, Khadija Ali   +6 more
openalex   +1 more source

CD103+ T Cells Eliminate Damaged Alveolar Epithelial Type II Cells Under Oxidative Stress to Prevent Lung Tumorigenesis

Advanced Science, Volume 12, Issue 28, July 24, 2025.
This work unravels a novel function of CD103+ T cells in eradicating oxidative‐stressed somatic cells to prevent lung tumorigenesis and identifies specific CD103+ T cell‐decline as a key feature in the aged lung. This comprehensive study highlights the contribution of immuno‐dysregulation to the high incidence of aging‐associated lung cancers ...
Yu Xu, Haorui Luo, Jiahao Wang, Haifeng Liu, Luonan Chen, Hongbin Ji, Zimu Deng, Xiaolong Liu   +7 more
wiley   +1 more source

Identification and validation of ARF6 for a potential prognostic biomarker of acute myeloid leukemia. [PDF]

Cancer Cell Int
Zhang C, Liu Y, Yuan X, Yang X, Yang B, Huang Y, Wang F, He Z, Li Y.   +8 more
europepmc   +1 more source