Results 61 to 70 of about 704,012 (340)

Heterozygous frameshift mutation in FaMYB10 is responsible for the natural formation of red and white-fleshed strawberry (Fragaria x ananassa Duch)

Frontiers in Plant Science, 2022
During natural evolution and artificial selection, the fruit color of many species has been repeatedly gained or lost and is generally associated with mutations in genes encoding R2R3-MYB transcription factors, especially MYB10.
Huazhao Yuan, Weijian Cai, Xiaodong Chen, Fuhua Pang, Jing Wang, Mizhen Zhao   +5 more
doaj   +1 more source

A common phytoene synthase mutation underlies white petal varieties of the California poppy. [PDF]

, 2019
The California poppy (Eschscholzia californica) is renowned for its brilliant golden-orange flowers, though white petal variants have been described.
Gong, Xue, Pollack, Andrew J, Pollack, Jonathan R   +2 more
core   +1 more source

The epithelial barrier theory proposes a comprehensive explanation for the origins of allergic and other chronic noncommunicable diseases

FEBS Letters, EarlyView.
Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu, Huseyn Babayev, Ismail Ogulur, Sena Ardicli, Yagiz Pat, Duygu Yazici, Bingjie Zhao, Lihong Chang, Xiaoqing Liu, Paolo D'Avino, Manru Li, Ceren Biçer, Fatma Hacer Kurtoğlu Babayev, Raja Dhir, Kari C. Nadeau, Marie‐Charlotte Brüggen, Mubeccel Akdis, Cezmi A. Akdis   +17 more
wiley   +1 more source

Diffusion tensor imaging of brain white matter in Huntington gene mutation individuals

Arquivos de Neuro-Psiquiatria
Objective To evaluate the role of the involvement of white matter tracts in huntingtin gene mutation patients as a potential biomarker of the progression of the disease. Methods We evaluated 34 participants (11 symptomatic huntingtin gene mutation, 12
Roberta Arb Saba, James H. Yared, Thomas M. Doring, Med Phys, Vanderci Borges, Henrique Ballalai Ferraz   +5 more
doaj   +1 more source

Molecular lesions associated with white gene mutations induced by I-R hybrid dysgenesis in Drosophila melanogaster [PDF]

, 1984
We have identified molecular lesions associated with six mutations, w(IR2) and w(IR4-8), of the white gene of Drosophila melanogaster. These mutations arose in flies subject to I-R hybrid dysgenesis.
Bucheton, A, Finnegan, David, Pelisson, A, Sang, Helen   +3 more
core   +1 more source

Bifurcation into functional niches in adaptation [PDF]

, 2004
One of the central questions in evolutionary biology concerns the dynamics of adaptation and diversification. This issue can be addressed experimentally if replicate populations adapting to identical environments Call be investigated in detail.
Adami, Christoph, White, Justin S.
core   +2 more sources

Development of visible light‐sensitive human neuropsin (OPN5) via single amino acid substitution

FEBS Letters, EarlyView.
The present study determines a key amino acid residue, Lys91, for defining UV sensitivity of human OPN5. Heterologous action spectroscopy of the wild type and K91 mutants of OPN5 in HEK293T cells reveals that substitution of Lys91 with neutral (alanine) or acidic amino acids (glutamic or aspartic acids) causes substantial shifts in spectral sensitivity
Yusuke Sakai, Richard J. McDowell, Robert J. Lucas   +2 more
wiley   +1 more source

MAP1B mutations cause intellectual disability and extensive white matter deficit [PDF]

Nature Communications, 2018
AbstractDiscovery of coding variants in genes that confer risk of neurodevelopmental disorders is an important step towards understanding the pathophysiology of these disorders. Whole-genome sequencing of 31,463 Icelanders uncovers a frameshift variant (E712KfsTer10) in microtubule-associated protein 1B (MAP1B) that associates with ID/low IQ in a large
Gudmundur L. Norddhal, Unnur Unnsteinsdottir, Gudrun A. Jonsdottir, Evald Saemundsen, Magnus I. Magnusson, Gardar Sveinbjornsson, Patrick Sulem, Andres Ingason, Asgeir Sigurdsson, Lina Jonsson, Lina Jonsson, Adalbjorg Jonasdottir, Valgerdur K. Eiriksdottir, Hreinn Stefansson, G. Bragi Walters, G. Bragi Walters, Arni F. Gunnarsson, Stacy Steinberg, Kari Stefansson, Kari Stefansson, Amy L. Lee, Magnus O. Ulfarsson, Magnus O. Ulfarsson, Omar Gustafsson, Askell Love, Daniel F. Gudbjartsson, Daniel F. Gudbjartsson, Muhammad Nawaz, Muhammad Nawaz, Aslaug Jonasdottir, Astros Skuladottir, Mike Frigge, Mark Zervas, Arna B. Agustsdottir   +33 more
openaire   +5 more sources

Somatic mutations of esophageal adenocarcinoma: a comparison between Black and White patients

Scientific Reports, 2023
Abstract Esophageal adenocarcinoma is the most common histological subtype of esophageal cancer in Western countries and shows poor prognosis with rapid growth. EAC is characterized by a strong male predominance and racial disparity. EAC is up to five-fold more common among Whites than Blacks, yet Black patients with EAC have poorer survival ...
Lim, Hyeyeun, Gingras, Marie-Claude, Zhao, Jing, Byun, Jinyoung, Castro, Patricia D, Tsavachidis, Spiridon, Hu, Jianhong, Doddapaneni, Harshavardhan, Han, Yi, Muzny, Donna M, Gibbs, Richard A, Amos, Christopher I, Thrift, Aaron P   +12 more
openaire   +4 more sources

Ergothioneine supplementation improves pup phenotype and survival in a murine model of spinal muscular atrophy

FEBS Letters, EarlyView.
Spinal muscular atrophy (SMA) is a genetic disease affecting motor neurons. Individuals with SMA experience mitochondrial dysfunction and oxidative stress. The aim of the study was to investigate the effect of an antioxidant and neuroprotective substance, ergothioneine (ERGO), on an SMNΔ7 mouse model of SMA.
Francesca Cadile, Daniela Ratto, Giorgia Rastelli, Ottavia Eleonora Ferraro, Caterina Temporini, Sunil Kumar, Simona Boncompagni, Paola Rossi, Monica Canepari   +8 more
wiley   +1 more source