Results 51 to 60 of about 194,933 (305)

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

open access: yesMolecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié   +16 more
wiley   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

open access: yesMolecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero   +11 more
wiley   +1 more source

Epidemiology in the context of white supremacy: critical questions to align the discipline with health equity

open access: yesCritical Public Health
Epidemiologists have a white supremacy problem. As epidemiologists, we know that a system designed to uphold the privilege of a particular class does not lend itself to health equity.
Jessie Seiler, Nadia N. Abuelezam
doaj   +1 more source

Ice Cream [PDF]

open access: yes, 2018
Ice Cream is a series of 2D and 3D depictions of lawn ornaments, Charlie Brown, and novelty ice cream bars, which question how White America is indoctrinated through seemingly innocuous images and objects.
Peterson, Richard Frank
core   +2 more sources

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

open access: yesMolecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz   +15 more
wiley   +1 more source

Learning from Black Lives Matter: Resisting Purity Culture in US Antitrafficking

open access: yesReligions, 2023
Persistent racial disparities in antitrafficking in the US reflect the antitrafficking movement’s reliance on a moral economy of purity and blamelessness that is steeped in White supremacy.
Yvonne C. Zimmerman
doaj   +1 more source

[Review of] George M. Fredrickson. Black Liberation: A Comparative History of Black Ideologies in the United States and South Africa [PDF]

open access: yes, 1995
George M. Fredrickson, Edgar E. Robinson Professor of United States History at Stanford University, has written a magisterial volume that complements his earlier explorations in his highly acclaimed White Supremacy and in some of his major essays in a ...
Williams, Vernon J., Jr
core   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

open access: yesMolecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra   +10 more
wiley   +1 more source

The Horne Thesis and Cold War Japan

open access: yesHistories
Gerald Horne’s explication of Cold War-era political history as negotiated white supremacy leads to an enhanced understanding of Japan in the Cold War.
Jason Michael Morgan
doaj   +1 more source

White Violence and Spectral Blackness in Don DeLillo’s Zero K

open access: yesCurrent Objectives of Postgraduate American Studies, 2020
Don DeLillo’s work is often framed as a visionary and ethical reflection on contemporary crises. Such reception redoubles an idea of white American farsightedness and morality that is already embedded in many of DeLillo’s stories—most recently in his ...
Mariya Dimitrova Nikolova
doaj   +1 more source

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