Results 101 to 110 of about 484,650 (308)
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Stark Racial Divisions in Reactions to Ferguson Police Shooting [PDF]
, 2014 Blacks and whites have sharply different reactions to the police shooting of an unarmed teen in Ferguson, Mo., and the protests and violence that followed.
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Tumor mutational burden as a determinant of metastatic dissemination patterns
Molecular Oncology, EarlyView.This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal +4 more
wiley +1 more source
Cause-specific contributions to sex differences in adult mortality among whites and African Americans between 1960 and 1995 [PDF]
The purpose of this paper is to describe trends in sex differences in mortality in young adulthood and in middle age among African Americans and whites in the United States between 1960 and 1995.
Greg L. Drevenstedt, Irma Elo
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Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Testing for Racial Differences in the Mental Ability of Young Children [PDF]
On tests of intelligence, Blacks systematically score worse than Whites, whereas Asians frequently outperform Whites. Some have argued that genetic differences across races account for the gap.
Roland G. Fryer, Steven D. Levitt
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Wealth and Asset Building: Black Facts [PDF]
, 2015 African American households lost 53% of their net worth between 2005 to 2009 compared to only16% of whites for the same time period. That translates into African Americans only having $17,100 in wealth compared to $170,400 for whites.
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RIPK4 function interferes with melanoma cell adhesion and metastasis
Molecular Oncology, EarlyView.RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski +9 more
wiley +1 more source
Through Boom and Bust: Minorities, Immigrants and Homeownership [PDF]
, 2009 Examines trends in 1995-2008 homeownership rates by race/ethnicity, nativity, and citizenship status; 2006-07 subprime lending to Hispanics/Latinos and African Americans by income level and compared with whites; and foreclosure rates by ...
Ana Gonzalez-Barrera +2 more
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COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source