Results 81 to 90 of about 484,650 (308)

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Nutrient Profiles of Korean-Americans, Non-Hispanic Whites and Blacks With and Without Hypertension in the United States

Asian Nursing Research, 2008
We compared the nutrient profiles of hypertensive Korean-Americans, non-Hispanic Whites and Blacks with those of normotensive Korean-Americans, Whites, and Blacks.
Mi-Ja Kim, RN, FAAN, PhD, Suk-Jeong Lee, RN, PhD, Yang-Heui Ahn, RN, HCNS, PhD, Phyllis Bowen, PhD, Hyeonkyeong Lee, RN, PhD   +4 more
doaj   +1 more source

Multiple sclerosis susceptibility alleles in African Americans. [PDF]

, 2010
Multiple sclerosis (MS) is an autoimmune demyelinating disease characterized by complex genetics and multifaceted gene-environment interactions. Compared to whites, African Americans have a lower risk for developing MS, but African Americans with MS have
Caillier, SJ, Cree, BCA, Cross, AH, De Jager, PL, Gourraud, P-AF, Hauser, SL, Herbert, J, Johnson, BA, Khan, OA, Oksenberg, JR, Taylor, EM, Wang, J   +11 more
core  

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Wage Differentials Are Larger Than You Think [PDF]

This paper will employ a method (devised in Lazear [1976] ) to estimate the unobserved component of wages. The size of this component will be calculated for non-whites and whites separately and then compared.
Edward P. Lazear
core  

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Differences in the College Enrollment Decision Across Race [PDF]

The gap in college enrollment rates between whites and blacks has remained stable since 1990, despite large increases in tuition and higher average wages for whites.
Robert Baumann
core  

Survey of Georgia Residents on HIV/AIDS [PDF]

, 2004
Presents findings from a survey that examines the disproportionate impact HIV/AIDS is having on African Americans in Georgia.

core  

White hallucinations

Postcolonial Studies, 2021
In this paper, the concept of white hallucination is developed through the prism of a recent debate about the permissibility of defending colonialism. The latter is, unsurprisingly, steeped in colonial nostalgia and a defence of free speech. These arguments, however, have to be related to the operation of whiteness itself.
openaire   +2 more sources