Results 91 to 100 of about 11,763,099 (219)
Advanced Science, EarlyView.A nebulized nanoassembly alleviates radiation‐induced lung injury by reprogramming macrophages through coordinated ROS scavenging, NAD+ replenishment, and PPAR‐γ activation. Redox balance, mitochondrial homeostasis, and immune regulation are restored, revealing a microenvironment‐centered strategy for localized radioprotection.
Mingquan Gao +11 more
wiley +1 more source
Advanced Science, EarlyView.This study unravels that bone fracture accelerates diabetic wound healing by releasing exosomal microRNA (miR‐130b‐3p). To mimic this bone‐skin crosstalk, we engineered a self‐assembling agomir‐130b‐3p nanocomplex. Delivered via a photocrosslinkable hydrogel, this bio‐inspired therapy provides sustained localized agomir release.
Tao Shen +14 more
wiley +1 more source
Abstract 052 | What is the impact of late-life rapamycin on exercise adaptations in older mice?
European Journal of Translational MyologyExercise is associated with decreased risk of multi-morbidity and mortality while rapamycin can extend lifespan and decrease age-related pathologies in model systems.
Adam R. Konopka
doaj +1 more source
Advanced Science, EarlyView.Using grilled lamb skewers as a model system, this work builds a multiscale coupling framework from oral processing to retronasal aroma perception, reveals dual‐kinetic release patterns and Electroencephalogram‐characterized central encoding features, and proposes an interpretable physics‐guided deep learning model validated by multiphysics simulation,
Che Shen +12 more
wiley +1 more source
Optimized Lipid Nanoparticles with Tail‐Modified Ionizable Lipids for Safer mRNA Delivery
Advanced Science, EarlyView.Systematic engineering of hydrophobic tail architecture in vitamin B5‐derived ionizable lipids establishes a comprehensive structure–activity relationship framework for mRNA delivery. Combined lipidtail and formulation optimization identifies TM1‐OPT3‐C, a lipid nanoparticle platform that improves efficacy–safety balance through efficient mRNA delivery,
Seo‐Hyeon Bae +27 more
wiley +1 more source
Advanced Science, EarlyView.This study introduces β‐glucan‐shielded apremilast laden nanomicelles that withstand gastrointestinal degradation, selectively accumulate in inflamed colon tissue, and modulate the microbiota–gut–brain axis. The formulation restores barrier integrity, reduces systemic and neuroinflammation, and improves anxiety‐ and depression‐like behaviors in colitis
Chandrashekhar Jori +10 more
wiley +1 more source
TrialsBackground Lung transplantation (LT) is indicated to increase the survival and quality of life of people with advanced lung disease. However, these patients often experience muscle mass loss and reduced physical capacity due to immobility and disease ...
Andrieli Barbieri Garlet +3 more
doaj +1 more source
Advanced Science, EarlyView.A flexible pressure sensor with triple‐gradient design of conductivity, modulus, and dimension in binary micro‐dome pixels is proposed. Based on precisely‐designed CNT/PDMS matrix, the device exhibits a linear sensitivity of 974.1 kPa−1 across range up to 1.8 MPa (R2 > 0.99), offering an effective strategy for potential applications in healthcare ...
Yifan Liu +9 more
wiley +1 more source
Black Hole Quencher‐Enhanced Plasmonic Photothermal Conversion
Advanced Science, EarlyView.Researchers have developed a universal method to boost plasmonic photothermal conversion by attaching black hole quencher (BHQ) molecules to matched metal nanostructures. This hybrid approach increases efficiency by roughly threefold, reaching up to 69.1% in the near‐infrared‐II window.
Ruiyuan Zhang +3 more
wiley +1 more source
Frontiers in ImmunologyPAPA syndrome (pyogenic sterile arthritis, pyoderma gangrenosum, and acne) is a rare autosomal dominant autoinflammatory disorder caused by mutations in the PSTPIP1 gene. In pediatric patients, arthritis often precedes cutaneous manifestations by several
Shuien He +7 more
doaj +1 more source