Results 1 to 10 of about 9,665 (128)

The Evolution in Understanding the Physiological Causes of Dyspnoea in Large Hiatal Herniation: A Narrative Review

ANZ Journal of Surgery, EarlyView.
ABSTRACT Background The symptomatology of large hiatus hernia (LHH) has been historically poorly understood, with cardiorespiratory symptoms caused by LHH being underappreciated by clinicians. This study reports on the mechanisms of dyspnoea in LHH through a historical review of symptoms and evolved physiological literature, discussing likely causation.
Arunan Mahendravarman, Fienne Cordeschi, Gregory Leighton Falk   +2 more
wiley   +1 more source

Alteration of the irisin–brain-derived neurotrophic factor axis contributes to disturbance of mood in COPD patients

International Journal of COPD, 2017
Csaba Papp,1 Krisztian Pak,2 Tamas Erdei,2 Bela Juhasz,2 Ildiko Seres,3 Anita Szentpéteri,3 Laszlo Kardos,4 Maria Szilasi,5 Rudolf Gesztelyi,2 Judit Zsuga1 1Department of Health Systems Management and Quality Management for Health Care, Faculty ...
Papp C, Pak K, Erdei T, Juhasz B, Seres I, Szentpéteri A, Kardos L, Szilasi M, Gesztelyi R, Zsuga J   +9 more
doaj  

Impact of Obesity on Lung Function in Cats with Bronchoconstriction

Veterinary Sciences, 2022
Obesity is a nutritional disorder commonly diagnosed in adult cats that has been associated with an increased risk of different chronic diseases including respiratory diseases.
Alicia Caro-Vadillo, J. Alberto Montoya-Alonso, Laín García-Guasch   +2 more
doaj   +1 more source

Physical Activity Profile of School‐Aged Children Born Very Preterm and Its Association With Sleep

Acta Paediatrica, EarlyView.
ABSTRACT Aim To describe the association between different physical activity and sleep parameters in school‐aged children born very preterm. Methods A cross‐sectional analysis was done in a cohort of 6‐ to 10‐year‐old children born at < 32 weeks' gestation at the Department of Neonatology, University of Tübingen, Germany.
Maham Hassan, Saskia Koller, Annkathrin Gies, Axel R. Franz, Johanna Catharina Brückner, Vadim Förster, Christian F. Poets, Christoph Randler, Cornelia Wiechers, Mirja Quante   +9 more
wiley   +1 more source

Therapeutic targeting of bleomycin‐induced pulmonary fibrosis by human bone marrow mesenchymal stem cell‐derived extracellular vesicles and/or pirfenidone: Impact of sex in mature adult mice

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease with limited therapeutic options. This study compared the therapeutic effects of bone marrow mesenchymal stem cell‐derived extracellular vesicles (BM‐MSC‐EVs) with an IPF treatment, pirfenidone (PFD), in mature adult mice with established pulmonary ...
Jennie S. Charoenphannathon, Simon G. Royce, Yasmin Higham, Jane E. Bourke, Chrishan S. Samuel   +4 more
wiley   +1 more source

More than skin-deep: visceral fat is strongly associated with disease activity, function and metabolic indices in psoriatic disease

Arthritis Research & Therapy, 2023
Objective To compare body composition between patients with psoriatic disease (PsD), including cutaneous psoriasis (PsO) and psoriatic arthritis (PsA), and controls, and to explore associations between disease activity and measures of function and ...
Tim Blake, Nicola J. Gullick, Charles E. Hutchinson, Abhir Bhalerao, Sarah Wayte, Andrew Weedall, Thomas M. Barber   +6 more
doaj   +1 more source

Direct evidence implicating the asymmetrical dimethylarginine (ADMA)‐dimethylarginine dimethylaminohydrolase 1 (DDAH1) pathway in cerebrovascular dysfunction and stroke pathogenesis in mice

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Asymmetrical dimethylarginine (ADMA) is an endogenous inhibitor of nitric oxide synthase (NOS), whereas dimethylaminohydrolase 1 (DDAH1) is primarily responsible for its metabolism. However, the roles of DDAH1 in cerebrovascular regulation are poorly understood. Furthermore, despite evidence that elevated ADMA levels are
Arun Flynn, Alexandra Riddell, Ashton Bernard, Jennifer Haggarty, Stefan Weidt, Jawza Alenazi, Erika Trabold, Delyth Graham, Laura B. Dowsett, James Leiper, Alyson A. Miller   +10 more
wiley   +1 more source

Respiratory Muscle Strength and Exercise Performance in Cystic Fibrosis–A Cross Sectional Study

Frontiers in Pediatrics, 2018
Introduction: Decreased respiratory muscle strength in patients with cystic fibrosis (CF) may cause progressive exercise intolerance during cardiopulmonary exercise testing (CPET), and may contribute to the development of chronic respiratory ...
Aleksandar Sovtic, Aleksandar Sovtic, Predrag Minic, Predrag Minic, Gordana Markovic-Sovtic, Goran Z. Trajkovic, Goran Z. Trajkovic   +6 more
doaj   +1 more source

Cannabinoid CB1 allosteric ligands suppress inflammatory pain in male mice without tolerance, motor impairment, memory deficits or respiratory depression

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Positive allosteric modulators (PAMs) engage sites distinct from the orthosteric CB1 cannabinoid receptor binding site. GAT211, a racemic ligand, contains GAT228 (R) and GAT229 (S) enantiomers. Whether enantiomer‐mediated differences in allosteric activation or positive allosteric modulation translate into differences in
Ifeoluwa D. Solomon, Sumanta Garai, Ganesh A. Thakur, Andrea G. Hohmann   +3 more
wiley   +1 more source

Characterisation of sleep apneas and respiratory circuitry in mice lacking CDKL5

Journal of Sleep Research, Volume 34, Issue 2, April 2025.
Summary CDKL5 deficiency disorder is a rare genetic disease caused by mutations in the CDKL5 gene. Central apneas during wakefulness have been reported in patients with CDKL5 deficiency disorder. Studies on CDKL5‐knockout mice, a CDKL5 deficiency disorder model, reported sleep apneas, but it is still unclear whether these events are central (central ...
Gabriele Matteoli, Sara Alvente, Stefano Bastianini, Chiara Berteotti, Elisabetta Ciani, Elenia Cinelli, Viviana Lo Martire, Giorgio Medici, Tommaso Mello, Elena Miglioranza, Alessandro Silvani, Donatella Mutolo, Giovanna Zoccoli   +12 more
wiley   +1 more source