Results 61 to 70 of about 155,426 (291)

Model-Based Detection of Whole-Genome Duplications in a Phylogeny [PDF]

Molecular Biology and Evolution, 2020
Abstract Ancient whole-genome duplications (WGDs) leave signatures in comparative genomic data sets that can be harnessed to detect these events of presumed evolutionary importance. Current statistical approaches for the detection of ancient WGDs in a phylogenetic context have two main drawbacks.
Zwaenepoel, Arthur, Van de Peer, Yves
openaire   +3 more sources

The impact of genome triplication on tandem gene evolution in Brassica rapa

Frontiers in Plant Science, 2012
Whole genome duplication (WGD) and tandem duplication (TD) are both important modes of gene expansion. However, how whole genome duplication influences tandemly duplicated genes is not well studied.
Lu eFang, Feng eCheng, Jian eWu, Xiaowu eWang   +3 more
doaj   +1 more source

Implementation of non-invasive prenatal testing by semiconductor sequencing in a genetic laboratory [PDF]

, 2016
Objectives: To implement non-invasive prenatal testing (NIPT) for fetal aneuploidies with semiconductor sequencing in an academic cytogenomic laboratory and to evaluate the first 15-month experience on clinical samples.
De Smet, Matthias, Dheedene, Annelies, Grisart, Bernard, Janssens, Sandra, Menten, Björn, Sante, Tom, Vanbellinghen, Jean-François, Vergult, Sarah   +7 more
core   +2 more sources

Gene content evolution in the arthropods [PDF]

, 2020
Arthropods comprise the largest and most diverse phylum on Earth and play vital roles in nearly every ecosystem. Their diversity stems in part from variations on a conserved body plan, resulting from and recorded in adaptive changes in the genome ...
Anstead, Clare A., Ayoub, Nadia A., Batterham, Phillip, Bellair, Michelle, Benoit, Joshua B., Binford, Greta J., Bornberg-Bauer, Erich, Chao, Hsu, Chen, Yolanda H., Childers, Christopher, Chipman, Ariel D., Dinh, Huyen, Doddapaneni, Harsha Vardhan, Dohmen, Elias, Duan, Jian J., Dugan, Shannon, Esposito, Lauren A., Friedrich, Markus, Garb, Jessica, Gasser, Robin B., Gibbs, Richard A., Glastad, Karl, Goodisman, Michael A. D., Gundersen-Rindal, Dawn E., Hackett, Kevin J., Hahn, Matthew W., Han, Yi, Handler, Alfred M., Hatakeyama, Masatsugu, Hering, Lars, Hughes, Daniel S. T., Hunter, Wayne B., Ioannidis, Panagiotis, Jayaseelan, Joy C., Kalra, Divya, Khila, Abderrahman, Korhonen, Pasi K, Lee, Carol Eunmi, Lee, Sandra L., Li, Yiyuan, Lindsey, Amelia R. I., Mayer, Georg, McGregor, Alistair P., McKenna, Duane D., Misof, Bernhard, Munidasa, Mala, Munoz-Torres, Monica, Murali, Shwetha C., Muzny, Donna M., Niehuis, Oliver, Osuji-Lacy, Nkechinyere, Palli, Subba R., Panfilio, Kristen A., Pechmann, Matthias, Perry, Trent, Peters, Ralph S., Pfrender, Michael E., Poelchau, Monica, Poynton, Helen C., Prpic, Nikola-Michael, Qu, Jiaxin, Richards, Stephen, Rotenberg, Dorith, Schal, Coby, Schoville, Sean D., Scully, Erin D., Skinner, Evette, Sloan, Daniel B., Stouthamer, Richard, Strand, Michael R., Szucsich, Nikolaus U., Thomas, Gregg W. C., Waterhouse, Robert M., Werren, John H., Wijeratne, Asela, Worley, Kim C., Young, Neil D., Zattara, Eduardo E., Zdobnov, Evgeny M.   +78 more
core   +5 more sources

Rearrangement Rate following the Whole-Genome Duplication in Teleosts [PDF]

Molecular Biology and Evolution, 2006
It is now clear that a whole-genome duplication (WGD) occurred at the base of the teleost fish lineage. Like the other anciently polyploid genomes investigated so far, teleost genomes now behave like diploids with chromosomes forming pairs at meiosis. The diploidization process is currently poorly understood.
Marie, Sémon, Kenneth H, Wolfe
openaire   +2 more sources

Coordinated functional divergence of genes after genome duplication in Arabidopsis thaliana [PDF]

, 2017
Gene and genome duplications have been rampant during the evolution of flowering plants. Unlike small-scale gene duplications, whole-genome duplications (WGDs) copy entire pathways or networks, and as such create the unique situation in which such ...
De Smet, Riet, Li, Zhen, Sabaghian, Ehsan, Saeys, Yvan, Van de Peer, Yves   +4 more
core   +1 more source

Whole Genome Duplications and Contracted Breakpoint Graphs

SIAM Journal on Computing, 2007
The genome halving problem, motivated by the whole genome duplication events in molecular evolution, was solved by El-Mabrouk and Sankoff in the pioneering paper [SIAM J. Comput., 32 (2003), pp. 754-792]. The El-Mabrouk-Sankoff algorithm is rather complex, inspiring a quest for a simpler solution.
Alekseyev, Max A., Pevzner, Pavel A.
openaire   +2 more sources

The driver landscape of sporadic chordoma. [PDF]

, 2017
Chordoma is a malignant, often incurable bone tumour showing notochordal differentiation. Here, we defined the somatic driver landscape of 104 cases of sporadic chordoma. We reveal somatic duplications of the notochordal transcription factor brachyury (T)
Alexandrov, Ludmil B, Amary, M Fernanda, Bashashati, Ali, Baumhoer, Daniel, Behjati, Sam, Brandner, Sebastian, Butler, Adam P, Campbell, Peter J, Cogswell, Patricia, Dickson, Brendan, Farndon, Sarah J, Flanagan, Adrienne M, Futreal, P Andrew, Guzzo, Charlotte, Hardy, Claire, Huntsman, David, Jamshidi, Farzad, Latimer, Calli, Martincorena, Inigo, Nielsen, Torsten O, Phillips, Joanna J, Pillay, Nischalan, Shah, Sohrab, Shlien, Adam, Sommer, Josh, Stratton, Michael R, Tarpey, Patrick S, Teague, Jon W, Tirabosco, Roberto, Wunder, Jay, Yip, Stephen, Young, Matthew D   +31 more
core   +2 more sources

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Landscape of standing variation for tandem duplications in Drosophila yakuba and Drosophila simulans [PDF]

, 2014
We have used whole genome paired-end Illumina sequence data to identify tandem duplications in 20 isofemale lines of D. yakuba, and 20 isofemale lines of D. simulans and performed genome wide validation with PacBio long molecule sequencing. We identify 1,
Andolfatto, Peter, Cridland, Julie M., Hu, Tina T., Rogers, Rebekah L., Shao, Ling, Thornton, Kevin R.   +5 more
core   +3 more sources