Results 61 to 70 of about 3,626,240 (269)

The wholeness of a cybernetician [PDF]

open access: yesSystems Research, 1993
AbstractAbstract ‐ It is our impression that Gordon Pask's writings cover fundamentals for large parts of the widely expanding fields of Cybernetics and Systems Theory. Thereby, and by his lecturing activities, he has become a unique figure in maintaining a kind of unity of the field of Cybernetics, well in accord with Wiener's view (“control and ...
openaire   +2 more sources

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

open access: yesFEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa   +2 more
wiley   +1 more source

Efficacy and Safety of Low Frequency Whole-Body Electromyostimulation (WB-EMS) to Improve Health-Related Outcomes in Non-athletic Adults. A Systematic Review

open access: yesFrontiers in Physiology, 2018
Exercise positively affects most risk factors, diseases and disabling conditions of middle to advanced age, however the majority of middle-aged to older people fall short of the exercise doses recommended for positively affecting cardio-metabolic ...
Wolfgang Kemmler   +16 more
doaj   +1 more source

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

open access: yesFEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara   +3 more
wiley   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

open access: yesFEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee   +7 more
wiley   +1 more source

Whole issue

open access: yesLanguage Value, 2011
Table of Contents From the editors Begoña Bellés-Fortuño Articles  Multimodal literacy in academic environments: PowerPoint as a motivational genre. Stefania Consonni PowerPoint Presentations in the classroom: Re-evaluating the genre. Larissa d’Angelo Listening with your eyes: Multimodal approaches to art appreciation in primary school.
openaire   +17 more sources

“Tüm” (Kull) Kavramı ve Geçmişe Matuf Varlıklar Zincirine Dair Hükme Etkisi: İbn Teymiyye Metinleri Üzerinden Bir Okuma

open access: yesAnkara Üniversitesi İlahiyat Fakültesi Dergisi
Bu çalışmada, İbn Teymiyye’nin (ö. 728/1328) evrene matuf varlıklar zincirine verdiği hükmün, benimsediği “tüm” (kull) kavramıyla ilişkisi ele alınmıştır.
Cihan Özaykan
doaj   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

open access: yesFEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

open access: yesFEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens   +8 more
wiley   +1 more source

Entering into a Community-University Collaboration

open access: yesJournal of Agriculture, Food Systems, and Community Development, 2018
First paragraph: When asked to tell the story of how and why I was invited and decided to join the Food Dignity research project, I found myself traveling back over a long road full of unexpected turns, bumps, discoveries, and delights. And as I began
E. Jemila Sequeira
doaj   +1 more source

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