Results 61 to 70 of about 5,774,229 (262)
Yapay Nesne Ontolojisinin İmkânı
Felsefe DünyasıBelli bir amacı yerine getirmek için insan eliyle maddenin modifiye edilmesiyle bilinçli bir biçimde yapılmış nesneler olarak tanımlanan yapay nesneler, Aristoteles’in doğal olarak var olan ve zanaatle var olan ayrımında ikincisine denk düşmüş ve ...
Şeyma Nur Tan
doaj +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Pan-cancer analysis of whole genomes
, 2020 Cancer is driven by genetic change, and the advent of massively parallel sequencing has enabled systematic documentation of this variation at the whole-genome scale 1–3 .
Adams, David J. +11 more
core +1 more source
Definition of Whole Grain and Determination of Content in Cereal Products
, 2021 Worldwide, dietary recommendations are given for increasing the intake of whole grain to improve health and well-being. A common definition of whole grain foods is important as international research and trade with foods are increasing.
Sveriges lantbruksuniversitet. +1 more
core +1 more source
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Mindful medical practice: An innovative core course to prepare medical students for clerkship
Perspectives on Medical Education, 2020 Background Medical students show a decline in empathy and ethical reasoning during medical school that is most marked during clerkship. We believe that part of the problem is that students do not have the skills and ways of being and relating necessary ...
Tom A. Hutchinson, Stephen Liben
doaj +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
International Journal of Whole Person Care, 2014 Objectives: Twenty-first century patients need to take a proactive stance with regard to their health in order to cope well with chronic illness. Mindfulness-Based Stress Reduction (MBSR) is an 8-week structured group program that encourages patients ...
Qinyi Zhao +2 more
doaj +1 more source