Results 81 to 90 of about 5,774,229 (262)

Emerging experimental and computational methods for studying redox‐regulated structural transitions

open access: yesFEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass   +2 more
wiley   +1 more source

Whole-body cortisol content.

open access: yes, 2018
Whole-body cortisol content in adult fathead minnows sampled in the lab before (0 min) and after a standardized stressor (30, 60, 240 min). For each boxplot, the line within the box represents the median whole-body cortisol concentration (n = 11–12). The
Bastien Sadoul (458121)   +3 more
core   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

open access: yesFEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge   +6 more
wiley   +1 more source

Artificial molecular machines and motors—Design and control of nanoscale motion

open access: yesFEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

Relation Between Whole and Part in Leibnitz Philosophy

open access: yesJournal of Philosophical Investigations, 2014
Here, on the one hand, regarding to the fundamental idea of Leibniz’s philosophy, namely, «Substance”, we will try to study the different kinds of whole and part and their relationship.
Zahra Nouri Sangdehi; Hourieh Bakoui Katrimi
doaj  

Entering into a Community-University Collaboration

open access: yesJournal of Agriculture, Food Systems, and Community Development, 2018
First paragraph: When asked to tell the story of how and why I was invited and decided to join the Food Dignity research project, I found myself traveling back over a long road full of unexpected turns, bumps, discoveries, and delights. And as I began
E. Jemila Sequeira
doaj   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

open access: yesFEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos   +9 more
wiley   +1 more source

Parts and wholes in language. The case of semantic underspecification

open access: yesGestalt Theory
The issue of the relations between parts and wholes is perhaps one of the most important theoretical issues of linguistic structuralism, to the point that it can be considered as a defining element of this very paradigm.
Cigana Lorenzo
doaj   +1 more source

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