Results 81 to 90 of about 3,626,240 (269)
Engineering ProceedingsVirtual lifetime estimation is growing in importance, as replacing physical tests by simulations leads to cost reductions in the development of microelectronics assemblies.
Yashveer Dunputh +5 more
doaj +1 more source
Review of Hybrid Finite Element – Statistical Energy Analysis methods in vehicle NVH predictions
Acta Technica Jaurinensis, 2019 In the vehicle industry, the noise, vibration and harshness (NVH) characteristics of a car are becoming more and more important. In order to control these, it is necessary to know the sources and contributors to the interior noise level.
Marcell Ferenc Treszkai, Dániel Feszty
doaj +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
BMC Complementary Medicine and TherapiesBackground Chronic obstructive pulmonary disease (COPD) and heart failure (HF) pose significant challenges to patients and the health systems that care for them.
Haitong Yu +8 more
doaj +1 more source
Meta-analysis of medical cannabis outcomes and associations with cancer
Frontiers in OncologyBackgroundGrowing bodies of evidence suggest that cannabis may play a significant role in both oncological palliative care and as a direct anticarcinogenic agent, but classification as a Schedule I substance has complicated research into its therapeutic ...
Ryan D. Castle +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Enhancing data practices for Whole Health: Strategies for a transformative future
Learning Health SystemsWe explored the challenges and solutions for managing data within the Whole Health System (WHS), which operates as a Learning Health System and a patient‐centered healthcare approach that combines conventional and complementary approaches.
Lei Guo +3 more
doaj +1 more source
FoodsIsoflavones, a class of substances with high biological activity, are abundant in soybeans. This study investigated isoflavone biosynthesis in soybean cell suspension cultures under UV-B radiation.
Mian Wang +6 more
doaj +1 more source
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source