Results 51 to 60 of about 9,716 (170)

Direct evidence implicating the asymmetrical dimethylarginine (ADMA)‐dimethylarginine dimethylaminohydrolase 1 (DDAH1) pathway in cerebrovascular dysfunction and stroke pathogenesis in mice

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Asymmetrical dimethylarginine (ADMA) is an endogenous inhibitor of nitric oxide synthase (NOS), whereas dimethylaminohydrolase 1 (DDAH1) is primarily responsible for its metabolism. However, the roles of DDAH1 in cerebrovascular regulation are poorly understood. Furthermore, despite evidence that elevated ADMA levels are
Arun Flynn, Alexandra Riddell, Ashton Bernard, Jennifer Haggarty, Stefan Weidt, Jawza Alenazi, Erika Trabold, Delyth Graham, Laura B. Dowsett, James Leiper, Alyson A. Miller   +10 more
wiley   +1 more source

Cannabinoid CB1 allosteric ligands suppress inflammatory pain in male mice without tolerance, motor impairment, memory deficits or respiratory depression

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Positive allosteric modulators (PAMs) engage sites distinct from the orthosteric CB1 cannabinoid receptor binding site. GAT211, a racemic ligand, contains GAT228 (R) and GAT229 (S) enantiomers. Whether enantiomer‐mediated differences in allosteric activation or positive allosteric modulation translate into differences in
Ifeoluwa D. Solomon, Sumanta Garai, Ganesh A. Thakur, Andrea G. Hohmann   +3 more
wiley   +1 more source

Characterisation of sleep apneas and respiratory circuitry in mice lacking CDKL5

Journal of Sleep Research, Volume 34, Issue 2, April 2025.
Summary CDKL5 deficiency disorder is a rare genetic disease caused by mutations in the CDKL5 gene. Central apneas during wakefulness have been reported in patients with CDKL5 deficiency disorder. Studies on CDKL5‐knockout mice, a CDKL5 deficiency disorder model, reported sleep apneas, but it is still unclear whether these events are central (central ...
Gabriele Matteoli, Sara Alvente, Stefano Bastianini, Chiara Berteotti, Elisabetta Ciani, Elenia Cinelli, Viviana Lo Martire, Giorgio Medici, Tommaso Mello, Elena Miglioranza, Alessandro Silvani, Donatella Mutolo, Giovanna Zoccoli   +12 more
wiley   +1 more source

Respiratory Muscle Strength and Exercise Performance in Cystic Fibrosis–A Cross Sectional Study

Frontiers in Pediatrics, 2018
Introduction: Decreased respiratory muscle strength in patients with cystic fibrosis (CF) may cause progressive exercise intolerance during cardiopulmonary exercise testing (CPET), and may contribute to the development of chronic respiratory ...
Aleksandar Sovtic, Aleksandar Sovtic, Predrag Minic, Predrag Minic, Gordana Markovic-Sovtic, Goran Z. Trajkovic, Goran Z. Trajkovic   +6 more
doaj   +1 more source

Parapharyngeal Fat Pads as an Obesity‐Related Parameter for Apnea‐Hypopnea Index Severity

Journal of Sleep Research, EarlyView.
ABSTRACT In this study, the association between obstructive sleep apnea severity and the parapharyngeal fat pad volume is examined in a population‐based sample. We included 680 participants who underwent standardised overnight polysomnography between 2008 and 2012 as part of the Study of Health in Pomerania in a sleep laboratory in Greifswald, Germany.
Antonia Felix, Amro Daboul, Tatyana Ivanovska, Peter Meisel, Ralf Ewert, Ingo Fietze, Thomas Penzel, Markus Krüger   +7 more
wiley   +1 more source

Positive correlation of airway resistance and serum asymmetric dimethylarginine level in COPD patients with systemic markers of low-grade inflammation

International Journal of COPD, 2017
Gabor Tajti,1,2 Rudolf Gesztelyi,3 Krisztian Pak,3 Csaba Papp,1 Sandor Keki,4 Magdolna Emma Szilasi,2 Angela Mikaczo,2 Andrea Fodor,2 Maria Szilasi,2 Judit Zsuga1 1Department of Health Systems Management and Quality Management for Health Care, Faculty ...
Tajti G, Gesztelyi R, Pak K, Papp C, Keki S, Szilasi ME, Mikaczo A, Fodor A, Szilasi M, Zsuga J   +9 more
doaj  

Utility and validity of dynamic chest radiography in cystic fibrosis (dynamic CF): an observational, non-controlled, non-randomised, single-centre, prospective study

BMJ Open Respiratory Research, 2020
Introduction Dynamic chest radiography (DCR) uses novel, low-dose radiographic technology to capture images of the thoracic cavity while in motion. Pulmonary function testing is important in cystic fibrosis (CF).
Matthew Shaw, Thomas Simon FitzMaurice, Paul Stephen McNamara, Dilip Nazareth, Caroline McCann, Ram Bedi, Martin Walshaw   +6 more
doaj   +1 more source

Thoracoabdominal Asynchrony in Healthy Children

Journal of Sleep Research, EarlyView.
ABSTRACT Measuring asynchrony between the thorax and abdomen during sleep provides information about inspiratory effort and upper airway obstruction in children, aiding in the diagnosis of obstructive sleep apnea (OSA). This study aimed to define a normative range for thoracoabdominal asynchrony (TAA) in healthy children by studying polysomnographies ...
Kristjan Dereksson, Sigrun Helga Lund, Agneta Markström, Sigridur Sigurdardottir, Erna Sif Arnardottir, Michael V. Clausen, Sigurveig T. Sigurdardottir, Tryggvi Helgason, Erik A. Eklund   +8 more
wiley   +1 more source

Simple low dose radiography allows precise lung volume assessment in mice

Scientific Reports, 2021
X-ray based lung function (XLF) as a planar method uses dramatically less X-ray dose than computed tomography (CT) but so far lacked the ability to relate its parameters to pulmonary air volume.
Amara Khan, Andrea Markus, Thomas Rittmann, Jonas Albers, Frauke Alves, Swen Hülsmann, Christian Dullin   +6 more
doaj   +1 more source

Differences in Sleep Spindle Characteristics Between Children With Narcolepsy and Those With Other Causes of Subjective Sleepiness

Journal of Sleep Research, EarlyView.
ABSTRACT Central disorders of hypersomnolence are characterised by excessive daytime sleepiness. There has been growing interest in analysing sleep micro‐architecture, to further understand how sleep is affected by these conditions. We investigated if sleep spindle activity differed between children with narcolepsy, idiopathic hypersomnolence (IH) and ...
Marisha Shetty, Nushrika Kadam Kishore, Georgina Plunkett, Lauren C. Nisbet, Margot J. Davey, Gillian M. Nixon, Lisa M. Walter, Rosemary S. C. Horne   +7 more
wiley   +1 more source