Results 141 to 150 of about 3,587,142 (311)

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

FEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss, Ao Li, Eduardo H. Gilglioni, Mayank Bansal, Sumeet Pal Singh, Latifa Bakiri, Alessandra K. Cardozo, Esteban N. Gurzov   +7 more
wiley   +1 more source

Probiotic Characterization, Safety and Whole Genome Association Analysis of Lacticaseibacillus rhamnosus Z23

Shipin gongye ke-ji
Lacticaseibacillus rhamnosus is one of the most researched and commercially utilized strains in recent years due to its excellent probiotic properties. In the present study, the in vitro probiotic properties of Lacticaseibacillus rhamnosus Z23, which was
Yuxing HE, Gaowa BAI, Jinghe YU, Wei LIU, Xiaofeng YANG, Mingchao LIU, Wuyundalai   +6 more
doaj   +1 more source

Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription

FEBS Open Bio, EarlyView.
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang, Mingqiang Deng, Dongmei He, Diqin Lai, Dongjun Liu, Dengyong Zhu, Zhenhua Zhang, Peng Tang, Chuanman Zhou, Menghui Yin, Xichen Bao   +10 more
wiley   +1 more source

Whole-genome sequencing quality metrics according to sample storage time.

, 2019
Whole-genome sequencing quality metrics according to sample storage time.
Johan Nilsson (364438), Maya Landenhed Smith (6804209), Bodil Andersson (700856), J. Gustav Smith (162179), Gustav Zar (6804206)   +4 more
core   +1 more source

Purification and preparation of Marchantia polymorpha Auxin Response Factor 2 for phase separation studies

FEBS Open Bio, EarlyView.
We describe detailed protocols for the purification and preparation of Marchantia polymorpha Auxin Response Factor 2 (MpARF2). This protein is fused to an MBP solubility tag and an mNG fluorescent tag and is purified from Escherichia coli. The presented procedures make it possible to study MpARF2 assemblies, which could arise from phase separation ...
Bas Janssen, Robin Romein, Willy A. M. van den Berg, Simon Lindhoud, Jan Willem Borst, Carlo P. M. van Mierlo   +5 more
wiley   +1 more source

Whole-genome SNP phylogeny (restricted dataset), related to Figure S3

, 2015
RAxML phylogenetic tree in newick format, obtained from the whole-genome SNP alignment of the restricted dataset and with S.
Raquel Barbosa (3322266), Dequin, Sylvie, Serra, Marta, Paula Gonçalves (129720), Zalar, Polona, Imanishi, Yumi, Kiminori Shimizu (276946), Shimizu, Kiminori, Couloux, Arnaud, Almeida, Pedro, Bensasson, Douda, Sampaio, José Paulo, Douda Bensasson (68342), Pedro Almeida (743373), Benedetta Turchetti (3322263), Sylvie Dequin (205208), Jean-Luc Legras (202388), Marta Serra (3322269), Julie Guy (478463), José Paulo Sampaio (218799), Gonçalves, Paula, Barbosa, Raquel, Arnaud Couloux (6018), Turchetti, Benedetta, Guy, Julie, Polona Zalar (536680), Legras, Jean-Luc, Yumi Imanishi (2481925)   +27 more
core   +1 more source

Dual native G‐quadruplex folding is associated with chromatin looping at the MYC locus

FEBS Open Bio, EarlyView.
BG4‐detectable G‐quadruplex (G4) in HaCaT and NHEK keratinocytes identified folded and unfolded G4s enriched at promoters/TSSs and active enhancers, whereas unfolded G4s also overlapped weak/poised enhancers. At MYC–PVT1, 3C‐qPCR detected enhancer–promoter looping only when G4s were simultaneously folded at both regulatory elements under native ...
Dieila Giomo de Lima, Gustavo Narvaes Guimarães, Emilyane de Oliveira Santana Amaral, Bianca Caroline Figueiredo Bianco, Manuel Jara‐Espejo, Sérgio Roberto Peres Line, Ana Paula de Souza, Aline Cristiane Planello   +7 more
wiley   +1 more source

Salmonella enterica serovar typhi limits the potency of typhoid toxin and ADP‐ribosylating toxin AB to establish a persistent infection

FEBS Open Bio, EarlyView.
The two catalytic subunits of typhoid toxin dissociate from the holotoxin in the ER of an intoxicated cell, but only CdtB exits the ER to generate immunosuppressive effects. PltA is retained in the ER and sequestered from its cytosolic target, thus allowing the anti‐inflammatory effects of CdtB to promote intestinal colonization.
Maria C. Zabala‐Rodriguez, Juliette K. Tinker, Teresa Frisan, Taj Azarian, Ken Teter   +4 more
wiley   +1 more source

A minimal cellulosome‐like system in Cellulosilyticum lentocellum

FEBS Open Bio, EarlyView.
Cellulose‐degrading bacteria typically use cellulosomes, large multi‐enzyme complexes on a scaffold protein. In Cellulosilyticum lentocellum, we characterise a far smaller arrangement, a single scaffold bound to one cellulase through a single cohesin‐dockerin interaction.
John Allan, Amias Alstrom‐Moore, Gary W Black   +2 more
wiley   +1 more source

Whole genome SNP genotype piecemeal imputation

, 2015
Background Despite ongoing reductions in the cost of sequencing technologies, whole genome SNP genotype imputation is often used as an alternative for obtaining abundant SNP genotypes for genome wide association studies.
Lin, Guohui, Wang, Yining, Stothard, Paul, Wylie, Tim   +3 more
core   +1 more source