Results 131 to 140 of about 3,587,142 (311)

Bridging the gap: a genetically validated avian chorioallantoic membrane platform for investigation of spontaneous circulating tumor cells

Molecular Oncology, EarlyView.
We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth, Rui P. L. Neves, Julia Geheb, Christian Ballmeyer, Nathalie Gaßmann, Kiki C. Andree, Monica Sudarsanam, Christiane Driemel, Celine Örencik, Andrè Franken, Eslam Elmaghraby, Sven H. Loosen, Roderburg Christoph, Sebastian Schoelch, Hans Neubauer, Wolfram T. Knoefel, Nikolas H. Stoecklein, Georg Fluegen   +17 more
wiley   +1 more source

Whole-Exome and Whole-Genome Sequencing of Candidate Pharmacogenomic and Schizophrenia-Related Genes in Sudanese Families with Schizophrenia

Pharmacogenomics and Personalized Medicine
Safa A Abdalla,1,2 Azza Saeed,3 Lamees Ahmed,3 Safa Abuswar,3 Mudathir Salih,3 Amel Eltigani,4 Iman H Abdoon,1 Bashier Osman,1 Muntaser E Ibrahim31Department of Pharmacology, Faculty of Pharmacy, University of Khartoum, Khartoum, Sudan; 2Department of ...
Abdalla SA, Saeed A, Ahmed L, Abuswar S, Salih M, Eltigani A, Abdoon IH, Osman B, Ibrahim ME   +8 more
doaj  

Enhanced Postbiotic Metabolite GABA Production in Skim Milk Using Weissella cibaria UF-274 and Whole-Genome Analysis

Metabolites
Background/Objectives: Gamma-aminobutyric acid (GABA) is a bioactive, non-proteinaceous amino acid with potential health benefits. Weissella cibaria UF-274 is an important lactic acid bacterium isolated from Balinese fermented sausage (urutan) with GABA ...
Ida Bagus Agung Yogeswara, Ni Wayan Nursini, I Gusti Ayu Wita Kusumawati, Rusli Fidriyanto, Dietmar Haltrich   +4 more
doaj   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

FEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata, Yoichi Sakai, Keisuke Tanaka, Etsuro Yoshimura, Ken Kitano, Morio Ishikawa, Tadahiro Nakamoto, Tsutomu Takayama, Hirofumi Inoue, Kaho Nomura, Tomonori Suzuki, Masataka Uchino, Akira Abe, Youichi Niimura   +13 more
wiley   +1 more source

Quality data of whole-genome-sequence and assembly.

, 2020
Quality data of whole-genome-sequence and assembly.
Fumihiko Takeuchi (118220), Hisako Kyan (4922593), Akinori Yamano (8394009), Tatsunori Masatani (497109), Toshihiro Matsui (1917), Takaya Sakura (2016025), Mami Murakami (791941), Kisaburo Nagamune (180747), Ryuma Matsubara (813362), Junpei Fukumoto (8394006), Michiru Tahara (180743), Motomichi Matsuzaki (78878), Tomohide Matsuo (46062), Yasuhiro Takashima (188527)   +13 more
core   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Screening the human exome: a comparison of whole genome and whole transcriptome sequencing.

, 2010
BACKGROUND: There is considerable interest in the development of methods to efficiently identify all coding variants present in large sample sets of humans.
Cirulli, Elizabeth T, Shianna, Kevin V, Maia, Jessica M, Ge, Dongliang, Heinzen, Erin L, Singh, Abanish, Goldstein, David B, Goedert, James J, Center for HIV/AIDS Vaccine Immunology (CHAVI), Smith, Jason P   +9 more
core   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Whole-genome sequences of 9 African samples

, 2019
This is the medatada associated with the European Nucleotide Archive (ENA) entry PRJEB28198.We sequenced 9 blood samples from different African populations on an Illumina HiSeq2000 sequencing platform.
Gerard Serra-Vidal (4809174), David Comas (791705), Belen Lorente (6448631), Oscar Lao (135632)   +3 more
core   +1 more source