Results 111 to 120 of about 3,587,142 (311)

Whole-genome sequencing libraries used in the mitochondrial divergence dating.

, 2023
Whole-genome sequencing libraries used in the mitochondrial divergence dating.
K. A. N. C. Jayawardane (16324805), A. U. Bandaranayake (16324802), R. C. Rajapakse (16324811), P. C. G. Bandaranayake (16324814), M. S. L. R. P. Marasinghe (16324796), M. G. C. Sooriyabandara (16324790), J. M. S. M. Jayasundara (16324793), R. M. R. Nilanthi (16324808), H. A. B. M. Hathurusinghe (16324799)   +8 more
core   +1 more source

Biological Characteristics Analysis of Limosilactobacillus reuteri JBR3 and the Effect of Protective Agents on Its Viability

Shipin gongye ke-ji
In order to advance the application of Limosilactobacillus reuteri IMAUJBR3 in meat fermenters, the strain was subjected to comprehensive genomic, metabolic and biological analyses. Additionally, one-way and response surface experiments were conducted to
Jun HAN, Yi WANG, Kaiping ZHANG, Jianjun TIAN   +3 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Transcriptome and methylome profiling reveals relics of genome dominance in the mesopolyploid Brassica oleracea [PDF]

, 2014
Background: Brassica oleracea is a valuable vegetable species that has contributed to human health and nutrition for hundreds of years and comprises multiple distinct cultivar groups with diverse morphological and phytochemical attributes.
John Nixon, Denoeud, France, Parkin, Isobel AP, Annaliese S Mason, Town, Chris D, Huebert, Terry, Sharpe, Andrew G., Manoli, Sahana, Bancroft, Ian, France Denoeud, Sateesh Kagale, Just, J\ue9r\ue9my, Robinson, Stephen J., Vivek Krishnakumar, Clarke, Carling, Links, Matthew G., Robinson, Stephen J, Wayne E Clarke, Guy Barker, Barker, Guy C., Shelby L Bidwell, Koh, Chushin, Moore, Jonathan D., Sharpe, Andrew G, Jacqueline Batley, Edwards, David, Clarke, Wayne E., Harry Belcram, Jérémy Just, Bidwell, Shelby L., Just, Jérémy, Carling Clarke, Jonathan Moore, Edwards, Dave, Nelson, Matthew N, David Edwards, Batley, Jacqueline, Matthew N Nelson, Stephen J Robinson, Sahana Manoli, Bidwell, Shelby L, Pires, J. Chris, Parkin, Isobel A. P., Chalhoub, Boulos, Terry Huebert, Andrew H Paterson, Krishnakumar, Vivek, Belcram, Harry, H., Walley, Peter G, Bender, Tricia, Tricia Bender, Town, Chris D., Nelson, Matthew N., King, Graham, J Pires, Mason, Annaliese S., Graham King, Pires, Chris J., Matthew G Links, Nixon, John, Chris D Town, Boulos Chalhoub, Links, Matthew G, Ian Bancroft, Belcram, Harry, Walley, Peter G., Mason, Annaliese S, Paterson, Andrew H, Walley, Peter Glen, Paterson, Andrew H., Moore, Jonathan, Barker, Guy, Kagale, Sateesh, Wang, Xiyin, Tang, Haibao, Pires, J Chris, Isobel AP Parkin, Pires, J., Andrew G Sharpe, Clarke, Wayne E, Xiyin Wang, Haibao Tang, Peter G Walley, Chushin Koh   +83 more
core   +1 more source

Whole genome sequencing in clinical practice

BMC Medical Genomics
Whole genome sequencing (WGS) is becoming the preferred method for molecular genetic diagnosis of rare and unknown diseases and for identification of actionable cancer drivers.
Frederik Otzen Bagger, Line Borgwardt, Andreas Sand Jespersen, Anna Reimer Hansen, Birgitte Bertelsen, Miyako Kodama, Finn Cilius Nielsen   +6 more
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Whole-Genome-Sequencing characterization of bloodstream infection-causing hypervirulent Klebsiella pneumoniae of capsular serotype K2 and ST374

, 2018
Hypervirulent K. pneumoniae variants (hvKP) have been increasingly reported worldwide, causing metastasis of severe infections such as liver abscesses and bacteremia.
Yingzhou Xie (2142268), Hongping Qu (5564069), Xiaobin Li (750526), Gang Li (34549), Jingyong Sun (322447), Xiaoli Wang (46677), Jialin Liu (1732168), Lijun Tian (6106226), Hong-Yu Ou (6754)   +8 more
core   +1 more source

High-resolution genotyping and mapping of recombination and gene conversion in the protozoan Theileria parva using whole genome sequencing [PDF]

, 2012
BACKGROUND: Theileria parva is a tick-borne protozoan parasite, which causes East Coast Fever, a disease of cattle in sub-Saharan Africa. Like Plasmodium falciparum, the parasite undergoes a transient diploid life-cycle stage in the gut of the arthropod ...
Spooner Paul R, Ulrich Certa, Pelle, R., Richard P Bishop, Ebeling, M., Pelle Roger, Lucy Poveda, Roger Pelle, Küng, Erich, Morzaria, S., Henson, Sonal, Morzaria, S.P., Erich Küng, Bishop, Richard P., Daubenberger, C.A., Daubenberger, Claudia A., Certa, U., Spooner, Paul R, Poveda, Lucy, Paul R Spooner, Poveda, L., Ebeling, Martin, Certa, Ulrich, Claudia A Daubenberger, Spooner, P.R., Weihong Qi, Sonal Henson, Bishop Richard P, Spooner, Paul R., Certa Ulrich, Henson Sonal, Henson, S., Morzaria Subhash, Qi Weihong, Poveda Lucy, Subhash Morzaria, Bishop, R. P., Spooner, P. R., Kung, E., Pelle, Roger, Ebeling Martin, Küng Erich, Daubenberger Claudia A, Morzaria, Subhash, Daubenberger, C. A., Bishop, Richard P, Martin Ebeling, Qi, W., Qi, Weihong, Daubenberger, Claudia A   +49 more
core   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source