Results 101 to 110 of about 3,587,142 (311)

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

FEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Utility of the pooling approach as applied to whole genome association scans with high-density Affymetrix microarrays. [PDF]

, 2010
Background: We report an attempt to extend the previously successful approach of combining SNP (single nucleotide polymorphism) microarrays and DNA pooling (SNP-MaP) employing high-density microarrays.
Farmer, A., Pirlo Katrina, Farmer, Anne E, Gray, J, Jones, L, Emma Meaburn (27672), Ian W Craig (16171385), Gaysina, D, Ian W Craig, Emma Meaburn, Craig, I., Korszun Ania, Cohen-Woods Sarah, Gray Joanna, Cohen-Woods, Sarah, Schalkwyk, L.C., McGuffin Peter, Darya Gaysina, Craig, Ian W, Farmer, AE, Schosser, A, Gray, J., Elkin, Amanda, Schalkwyk, L., Gray, Joanna, Craig, IW, Schalkwyk Leonard C, Schosser Alexandra, Lisa Jones (98953), Gunasinghe, C, Sarah Cohen-Woods (214940), Pirlo, K., Craig, I.W., Jones Lisa, Alexandra Schosser (214931), Gaysina Darya, Cerisse Gunasinghe (16171376), Schosser, Alexandra, McGuffin, P., Meaburn Emma, Meaburn, E., Amanda Elkin, Leonard C Schalkwyk, Alexandra Schosser, Ania Korszun (214946), Anne E Farmer, Joanna Gray, Lisa Jones, McGuffin, P, Pirlo, Katrina, Elkin Amanda, Katrina Pirlo, Gaysina, Darya, Schosser, A., Elkin, A., Schalkwyk, LC, Korszun, A., Peter McGuffin, Gunasinghe, Cerisse, Amanda Elkin (16049114), Craig Ian W, Sarah Cohen-Woods, Joanna Gray (16171373), Anne E Farmer (10497512), Farmer Anne E, Gaysina, Daria, Ania Korszun, Pirlo, K, Gunasinghe, C., Peter McGuffin (51507), Meaburn, Emma L., Elkin, A, Katrina Pirlo (14918094), Gaysina, D., Cerisse Gunasinghe, Korszun, A, Farmer, A.E., McGuffin, Peter, Korszun, Ania, Jones, Lisa, Leonard C Schalkwyk (8412954), Cohen-Woods, S, McGuffin, Peter W, Meaburn, E, Darya Gaysina (4464832), Schalkwyk, Leonard C, Cohen-Woods, S., Gunasinghe Cerisse, Jones, L., Gunasinghe, Cerisse; id_orcid, Meaburn, Emma   +90 more
core   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

KvarQ: targeted and direct variant calling from fastq reads of bacterial genomes [PDF]

, 2014
High-throughput DNA sequencing produces vast amounts of data, with millions of short reads that usually have to be mapped to a reference genome or newly assembled.
Steiner, Andreas, Sebastien Gagneux, David Stucki, Andreas Steiner, Borrell, Sonia, Stucki, David, Sonia Borrell, Gagneux, Sebastien, Mireia Coscolla, Coscolla, Mireia   +9 more
core   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Whole genome amplification for PGD and PND; molecular and a-CGH diagnosis [PDF]

, 2009
Whole genome amplification amplifies the entire genome in a few hours from samples of minimal DNA quantities, even from single cells. This may have many applications, especially in prenatal diagnosis, PGD and PGS. The hypothesis for chapter 3 was: Can
Glentis, S.
core  

Research Advances and Analysis in Whole Genome Studies of Rhododendron

Guangdong nongye kexue
Rhododendron, a genus within the family Ericaceae, encompasses over 1 000 species globally and represents a significant genetic resource with considerable value in ornamental horticulture, medicinal applications, and ecological restoration.
Jianshuang SHEN, Xianlin RONG, Mingli ZHANG, Chunhai WEI   +3 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source