Results 91 to 100 of about 3,587,142 (311)

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

The Capsaspora genome reveals a complex unicellular prehistory of animals [PDF]

, 2013
To reconstruct the evolutionary origin of multicellular animals from their unicellular ancestors, the genome sequences of diverse unicellular relatives are essential. However, only the genome of the choanoflagellate Monosiga brevicollis has been reported
Chen, Zehua, Kerner, Pierre, Ruiz-Trillo, Iñaki, Vervoort, Michel, Sánchez-Pons, Núria, Russ, Carsten, Kramer, Eric, Carr, Martin, Roger, Andrew J., Suga, Hiroshi, Nusbaum, Chad, de Mendoza, Alex, Haas, Brian J., Lang, B. Franz, Manning, Gerard, Sebé-Pedrós, Arnau, Torruella, Guifré, Derelle, Romain, Brown, Matthew W., Mendoza, Alex de   +19 more
core   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Bioinformatics' approaches to detect genetic variation in whole genome sequencing data [PDF]

, 2010
Current genetic marker repositories are not sufficient or even are completely lacking for most farm animals. However, genetic markers are essential for the development of a research tool facilitating discovery of genetic factors that contribute to ...
Kerstens, H.H.D.
core  

Whole-genome enrichment and sequencing of Chlamydia trachomatis directly from clinical samples [PDF]

, 2014
Background: Chlamydia trachomatis is a pathogen of worldwide importance, causing more than 100 million cases of sexually transmitted infections annually.
Holdstock, J., Brown, A., Williams, R., Kundu, S., Breuer, J., Holland, M., Stevenson, S., Christiansen, M., Dave, J., Depledge, D., Tong, W., Einer-Jensen, K., Tutill, H., Brown, J.   +13 more
core   +1 more source

Culture-free whole genome sequencing analysis of

Scientific African
Background: The prevalence of chancroid, which is caused by Haemophilus ducreyi , has declined globally. However, H. ducreyi remains a cause of genital ulcer disease in some sub-Saharan African countries and causes non-genital cutaneous ulcers in ...
Daniel Golparian, Mitch M Matoga, Daniel Schröder, Jane S Chen, Sarah E Rutstein, Farhang Aghakhanian, Jonathan B Parr, Irving Hoffman, Arlene C Seña, Magnus Unemo   +9 more
doaj   +1 more source

Future of whole genome sequencing [PDF]

Journal of Paediatrics and Child Health, 2014
The era of genomic medicine, anticipated since the completion of the Human Genome Project in 2003, is now upon us. Before long, genomic information will be an integral part of the medical record, and paediatricians will be able to interrogate these data for a range of purposes: to make a diagnosis in a sick child, to diagnose or exclude a rare genetic ...
openaire   +2 more sources

Whole exome and whole genome sequencing with dried blood spot DNA without whole genome amplification [PDF]

Human Mutation, 2017
Newborn screening (NBS) for rare conditions is performed in all 50 states in the USA. We have partnered with the California Department of Public Health Genetic Disease Laboratory to determine whether sufficient DNA can be extracted from archived dried blood spots (DBS) for next-generation sequencing in the hopes that next-generation sequencing can play
Laia Bassaganyas, George Freedman, Dedeepya Vaka, Eunice Wan, Richard Lao, Flavia Chen, Mark Kvale, Robert J. Currier, Jennifer M. Puck, Pui-Yan Kwok   +9 more
openaire   +4 more sources

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

A New Whole Genome Culture-Independent Diagnostic Test (WG-CIDT) for Rapid Detection of Salmonella in Lettuce

Frontiers in Microbiology, 2020
The rapid detection of foodborne microbial pathogens contaminating fresh fruits and vegetables during the intervening period between harvest and consumption could revolutionize microbial quality assurance of food usually consumed raw and those with a ...
Dele Ogunremi, Andrée Ann Dupras, Sohail Naushad, Ruimin Gao, Ruimin Gao, Marc-Olivier Duceppe, Katayoun Omidi, Imelda Galván Márquez, Hongsheng Huang, Lawrence Goodridge, Roger C. Lévesque, Nur A. Hasan, Manoj Dadlani, Brent Dixon, Sebastian Magierowski, Luke Masson   +15 more
doaj   +1 more source