Results 71 to 80 of about 3,587,142 (311)

Whole-genome sequencing identified somatic mutations in 100 gastric cancers

, 2022
This dataset contains list of somatic mutations identified by whole-genome sequencing in 100 gastric cancers. Whole genome sequencing data was generated from gastric tumor frozen tissues and blood leukocyte DNA.
Suet Yi Leung (9049226)
core   +1 more source

Biological characteristics and genomic analysis of a novel Vibrio parahaemolyticus phage phiTY18 isolated from the coastal water of Xiamen China

Frontiers in Cellular and Infection Microbiology, 2022
Vibrio parahaemolyticus is a common pathogen usually controlled by antibiotics in mariculture. Notably, traditional antibiotic therapy is becoming less effective because of the emergence of bacterial resistance, hence new strategies need to be found to ...
Bo Liu, Tingyi Zheng, Rui Quan, Xinglong Jiang, Guixiang Tong, Xinxian Wei, Mao Lin, Mao Lin   +7 more
doaj   +1 more source

Comparison of whole genome assemblies of the human genome [PDF]

Nucleic Acids Research, 2002
A fundamental problem in the human genome project is uncovering the correct assembly of the human genome. Many studies, including transcriptional analysis, SNP detection and characterization, gene finding and EST clustering, use genome assemblies as templates so it is important to determine the consistency among the various whole genome assemblies.
Eric C, Rouchka, Warren, Gish, David J, States   +2 more
openaire   +2 more sources

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Low-Volume On-Chip Single-Cell Whole Genome Amplification for Multiple Subsequent Analyses

, 2015
Multiple analyses such as DNA profiling, sequencing, or comparative genome hybridization (CGH) done on the single-cell level long for pre-amplification due to the diploid human genome.
Amin El-Heliebi, Thomas Kroneis, El-Heliebi, A., Shukun Chen, Kroneis, Thomas,, Chen, S.   +5 more
core   +1 more source

Genome sequencing defines phylogeny and spread of methicillin-resistant Staphylococcus aureus in a high transmission setting. [PDF]

, 2014
Methicillin-resistant Staphylococcus aureus (MRSA) is a major cause of nosocomial infection. Whole-genome sequencing of MRSA has been used to define phylogeny and transmission in well-resourced healthcare settings, yet the greatest burden of nosocomial ...
Thaipadungpanit, J, Holden, MTG, Cauchemez, S, Jombart, Thibaut, Tong, SY, Nickerson, Emma K, Hongsuwan, M, Cori, A, Cauchemez, Simon, Holden, Matthew T G, Parkhill, J, Köser, CU, Tong, SYC, Nickerson, EK, Day, Nicholas P, Day, NP, Holden, MT, Fraser, C, Tong, Steven Y C, Fraser, Christophe, Limmathurotsakul, Direk, Limmathurotsakul, D, Cooper, Ben, Wuthiekanun, Vanaporn, Peacock, SJ, Köser, Claudio U, Wuthiekanun, V, Cooper, BS, Cori, Anne, Parkhill, Julian, Cooper, Ben S, Day, Nicholas, Thaipadungpanit, Janjira, Peacock, Sharon J, Jombart, T, Hongsuwan, Maliwan   +35 more
core   +2 more sources

Multiple Mechanisms Confer Resistance to Azithromycin in Shigella in Bangladesh: a Comprehensive Whole Genome-Based Approach

Microbiology Spectrum, 2022
Shigella is the second leading cause of diarrheal deaths worldwide. Azithromycin (AZM) is a potential treatment option for Shigella infection; however, the recent emergence of AZM resistance in Shigella threatens the current treatment strategy. Therefore,
Suraia Nusrin, Asaduzzaman Asad, Shoma Hayat, Bitali Islam, Ruma Begum, Fahmida Habib Nabila, Zhahirul Islam   +6 more
doaj   +1 more source

Whole-Genome Annotation with BRAKER [PDF]

, 2019
BRAKER is a pipeline for highly accurate and fully automated gene prediction in novel eukaryotic genomes. It combines two major tools: GeneMark-ES/ET and AUGUSTUS. GeneMark-ES/ET learns its parameters from a novel genomic sequence in a fully automated fashion; if available, it uses extrinsic evidence for model refinement.
Katharina J, Hoff, Alexandre, Lomsadze, Mark, Borodovsky, Mario, Stanke   +3 more
openaire   +2 more sources

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Energetics of whole genome doubling and genomic instability

Cancer Letters
Whole genome doubling (WGD) is among the most prevalent genomic alterations in cancer, present in approximately one third of patients at the time of diagnosis. WGD provides cancer cells with a selective advantage, by protecting against mutations in haploinsufficient genes or buffering deleterious mutations.
Beck, Richard, Tagal, Vural, Amin, Samir, Bakhoum, Samuel F., Maley, Carlo, Verhaak, Roel G.W., Gomes, Ana P., Andor, Noemi   +7 more
openaire   +3 more sources